+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors

, : The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors. Immunity 41(3): 389-401

Adaptation of malignant cells to the hostile milieu present in tumors is an important determinant of their survival and growth. However, the interaction between tumor-linked stress and antitumor immunity remains poorly characterized. Here, we show the critical role of the cellular stress sensor C/EBP-homologous protein (Chop) in the accumulation and immune inhibitory activity of tumor-infiltrating myeloid-derived suppressor cells (MDSCs). MDSCs lacking Chop had decreased immune-regulatory functions and showed the ability to prime T cell function and induce antitumor responses. Chop expression in MDSCs was induced by tumor-linked reactive oxygen and nitrogen species and regulated by the activating-transcription factor-4. Chop-deficient MDSCs displayed reduced signaling through CCAAT/enhancer-binding protein-β, leading to a decreased production of interleukin-6 (IL-6) and low expression of phospho-STAT3. IL-6 overexpression restored immune-suppressive activity of Chop-deficient MDSCs. These findings suggest the role of Chop in tumor-induced tolerance and the therapeutic potential of targeting Chop in MDSCs for cancer immunotherapy.


PMID: 25238096

DOI: 10.1016/j.immuni.2014.08.015

Other references

Jones, D.G.; Bradford, H.F., 1971: The relationship between complex vesicles, dense-cored vesicles and dense projections in cortical synaptosomes. Cortical synaptosomes fixed in unbuffered OsO4 and glutaraldehyde have been block-stained with phosphotungstic acid (PTA) in order to investigate the relationship between complex vesicles and dense projections. It is concluded that the shell of th...

Manil, G., 1963: Humus, forest capacity, and forest site mappin. Transactions International Society Soil Science, Commissions IV and V 1962 814-819

A.C.alabi K.A.K.; Qazzaz H.M.A., 1981: The effects of acclimation temperatures on thymidylate synthetase and thymidine phosphorylase activities of the fresh water snails lymnaea auricularia. L. auricularia (L) contains 2 enzymes involved in the thymine nucleotide metabolism, thymidylate synthetase and thymidine phosphorylase. The activity of these 2 enzymes increased with cold acclimation (Precht's type-3 capacity compensation)....

DiIorio, C.; Resnicow, K.; McDonnell, M.; Soet, J.; McCarty, F.; Yeager, K., 2003: Using motivational interviewing to promote adherence to antiretroviral medications: a pilot study. This report describes a pilot study of a nursing intervention to increase adherence to combination therapy. The intervention was based on motivational interviewing (MI). Participants completed a baseline assessment using the computer-administered...

Mezhnev, AP., 2003: In memoriam of Igor Shurupov. Ornitologiya, 30: 243-244

Anonymous, 1982: Biological studies in Central America. Annals of the Missouri Botanical Garden 69(3 ): 1-734

Al-Izzi, M.A.J.; Hopkins, T.L., 1982: Effects of dietary sterols on development and reproduction of southwestern corn borer Diatraea grandiosella Dyar. Southwestern corn borer larvae, D. grandiosella Dyar., were reared on artificial diets containing individual sterols (cholesterol, sitosterol or stigmasterol) in concentrations ranging from 0.05-0.2%. Female larvae developed to pupae more rapidly...

Pax, F., 1918: Die Antipatharien. Zoologische Jahrbuecher (Systematik): 41 419-478

Miki T., 1985: Coal-bearing formations in Japan. Geologia (Warszawa) 11(2): 19-36

Anonymous, 1943: Experiment with Finnish strains of timothy. In connexion with the use of Finnish "<O>sterbottnia" timothy seed in the northern parts of Norway, the question has been examined whether seed imported from various more northerly Finnish latitudes is more winter hardy in northern...