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The use of beta-cyclodextrin in the manufacturing of disintegrating pellets with improved dissolution performances


, : The use of beta-cyclodextrin in the manufacturing of disintegrating pellets with improved dissolution performances. Aaps Pharmscitech 9(2): 708-717

It has recently been highlighted that the release behavior of pellets containing microcystalline cellulose (MCC) as the spheronizing agent may be impaired by the lack of disintegration. Although alternative spheronizing excipients have been proposed, their overall advantages have not thoroughly been assessed. In the present work, the possible use of beta-cyclodextrin (betaCD) was therefore explored for the manufacturing of pellets with a potential for effective disintegration and immediate release of poorly soluble active ingredients. MCC/betaCD powder formulations containing no drug or model drugs with different water solubility, able to form inclusion compounds with the employed cyclodextrin, were pelletized by agglomeration in rotary fluid bed equipment. By applying successive statistical experimental designs, the most critical formulation and operating parameters were identified and optimal manufacturing processes were ultimately set up. High yields of pellets provided with satisfactory physical-technological characteristics were obtained using powder formulations with up to 80% betaCD. Based on dissolution testing results, the suitability of betaCD for the preparation of disintegrating MCC-containing pellets with improved dissolution performance was finally demonstrated.

US$19.90

PMID: 18523889

DOI: 10.1208/s12249-008-9106-0


Other references

Duncan Ian J., 1984: Strain paths and strain fields; a new approach to problems in incremental strain analysis. Abstracts with Programs - Geological Society of America 16(6): 496

Beier, R., 1993: Bacteriological studies on the occurrence of Clostridium difficile and salmonellas in horses. C. difficile was present in faeces from 0.6% of 161 healthy foals and 8.1% of 115 foals and adult horses with diarrhoea. Cytotoxin was present in 3 of 15 positive samples. Salmonella typhimurium var. copenhagen was recovered from 1.1% of 375 healt...

Adcock, E., 2007: Iowa State University offers new degree in seed technology and business. Integrated crop management: y 30, no 21

Wu, L.; Yee, A.; Liu, L.; Carbonaro-Hall, D.; Venkatesan, N.; Tolo, V.T.; Hall, F.L., 1994: Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase. Cyclin-dependent, proline-directed protein kinases normally function to execute critical cell cycle transitions; abnormal expression and/or viral subversion of the positive (cyclins) and negative (Pic1) regulatory subunits may contribute to neopla...

Tay, L.K.; Lee, H.Y.; Thirumoorthy, T.; Pang, S.M., 2011: Dermatology referrals in an East Asian tertiary hospital: a need for inpatient medical dermatology. Within hospitals, there is a need for dermatological expertise, as hospitalized patients have a wider spectrum of severe and serious dermatological conditions, associated with significant morbidity. To characterize the patient profile and referral...

Lelievre J.; Navntoft E., 1980: Measuring sediment load in the Parana River. International Water Power and Dam Construction 32(4): 21-24

Taubitz, L.E.; Robinson, J.S.; Larson, C.L., 2013: Modulation of the startle reflex across time by unpleasant pictures distinguishes dysphoric from non-dysphoric women. While several investigators have examined differences in affective startle modulation between individuals with and without Major Depressive Disorder, fewer researchers have evaluated the time course of this response, particularly in dysphoric indi...

Tuatay, N., 1988: Aphididae (Homoptera) of Turkey. I. Aphidinae: Macrosiphini (1st Part). In this 1st paper in a series on the aphid fauna of Turkey, methods that were used for collecting the specimens and mounting them on slides are described, and data are presented on 45 species in 17 genera of the subfamily Aphidinae, tribe Macrosip...

Margulies L.J.; Grand M.G., 1988: Endophthalmitis. Spoor, T C And F A Nesi (Ed ) Management Of Ocular, Orbital, And Adnexal Trauma Xiv+445p Raven Press: New York, New York, Usa Illus 137-152

Vuylsteek, K., 1973: Introduction to an exchange of ideas on job evaluation. Bruxelles Medical 53(1): 17-18