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Therapy of advanced squamous cell carcinoma of the skin

, : Therapy of advanced squamous cell carcinoma of the skin. Current Treatment Options in Oncology 15(2): 302-320

Advanced unresectable squamous cell carcinoma of the skin (SCCS) is a rare condition, which is difficult to treat. Because of its rarity, few therapeutic trials are available. Moreover, SCCS often occur in elderly. Conventional treatment options for advanced SCCS are chemotherapy mainly with cisplatin-based regimens. Immunotherapy with interferon alpha and retinoids combination was also shown to be efficient. Toxicity of these treatments limits, however, their use in elderly patients and an initial work up for a global assessment is needed in order to adapt the choice. More recently, epithelial growth factor receptor (EGFR) targeted therapies have been developed and induced interesting response rates in small series of patients with unresectable SCCS. Their efficacy in SCCS must be confirmed by larger phase III trials and the identification of predictive biological factors of response is warranted. New therapeutic approaches combining EGFR inhibitors either with IGFR inhibitors, or immunomodulators or inhibitors of the PI3K/AKT/mTOR pathway are currently under evaluation in head and neck carcinomas and might represent valuable therapeutic approaches for unresectable SCCS. Moreover, there are several new molecular candidate treatment targets for unresectable SCCS including somatic NOTCH1 or NOTCH2 inactivating mutations, ALK1, which could be a good candidate for antiangiogenic therapy and matrix metallopeptidase 7, which enhances proliferation, migration, and invasion of cancer cells. Organ transplant recipients often develop SCCS and in some patients, SCCS are rapidly progressing. Management of SCCS in this subgroup of patients includes both carcinologic treatment and modification of immunosuppression. Specific treatment is generally the same as in immunocompetent patients. Switching from calcineurin inhibitors to sirolimus or reducing immunosuppression has to be considered.


PMID: 24643778

DOI: 10.1007/s11864-014-0280-x

Other references

Huang, W-Ji.; Shen, Y.; Xu, X-Yan.; Hu, M-Yan.; Li, J-le., 2016: Identification and characterization of the TLR18 gene in grass carp (Ctenopharyngodon idella). Toll-like receptors (TLRs) play a critical role in the innate immune system. Although TLR18 is an important member of this family of receptors in fish, the role of the tlr18 gene in responses to pathogen infection is still unclear. In this study,...

Wasserstrum, N.; Herd, J.A., 1977: Elevation of arterial blood pressure in the squirrel monkey at 10 degrees C. Systemic arterial blood pressure, heart rate, and total body oxygen consumption were measured in seven unanesthetized squirrel monkeys exposed to ambient temperatures of 28 degrees C and 10 degrees C. At 28 degrees C, subjects sat quietly, the ave...

Vignola P.A.; Aonuma K.; Swaye P.S.; Rozanski J.J.; Blankstein R.L.; Benson J.; Gosselin A.J.; Lister J.W., 1984: Clinically silent myocarditis and ventricular tachycardia. American Heart Association Monograph (107): II-403

Rodrigo, C.; de Silva, A.; Lanerolle, R., 2014: Symptoms of anxiety among patients with chronic kidney disease in Sri Lanka. Saudi Journal of Kidney Diseases and Transplantation 24(6): 1256-1257

Guillemin, M.P.; Litzistorf, G.; Buffat, P.A., 1989: Urinary fibres in occupational exposure to asbestos. Urine samples from 10 workers from an asbestos cement factory and from a control group of 10 workers from a foundry, were obtained; drastic precautions were taken to avoid contamination. Each urinary mineral fibre was sized and identified by trans...

Elnenaei, M.O.; Jadayel, D.M.; Matutes, E.; Morilla, R.M.; Owusu Ankomah, K.A.; Atkinson, S.; Titley, I.; Mandala, E.M.; Catovsky, D., 1999: A flow cytometry method for cyclin D1 in B-cell malignancies. Blood 94(10 SUPPL 1 PART 1): 83a, Nov 15

Ahmed, S.; Oh, H.Boon.; Kheng, D.Lincoln.Loh.Ser.; Krishnan, P., 2017: Case report of successful partial splenectomy for a splenic abscess in a paediatric patient. Splenic abscess (SA) is a rare potentially fatal condition in the paediatric population. It is difficult to diagnose given its non-specific presentation. There are no current guidelines for management of SA in this population but splenic preservat...

M'harzi M.; Monmaur P., 1984: Differential effect of fornix and fimbria lesions on the theta rhythm of the ammons horn 1 area and the gyrus dentatus of the dorsal hippocampus in the rat. Journal de Physiologie (Paris) 79(3): 44A

Williamson B., 1987: Effect of fenitrothion and benomyl sprays on raspberry cane midge resseliella theobaldi and midge blight with particular reference to leptosphaeria coniothyrium in the disease complex. The incidence of vascular lesions caused by fungi associated with the infection of young canes by the raspberry cane midge (Resseliella theobaldi) was studied in plots of red raspberry cvs Glen Clova and Malling Jewel given a five-spray eradicant...

Zheng, R-Hui.; Wei, W-Mei., 2007: Density functional theory study on anti-resonance in preresonance Raman scattering for naphthalene molecules. The anti-resonance phenomenon in preresonance Raman scattering is investigated on the basis of the direct Taylor expansion of the electric dipole transition moments in vibrational Raman tensors with respect to vibrational normal coordinates. A tim...