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Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead

, : Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead. European Journal of Medicinal Chemistry 86: 684-689

Five novel acetogenin analogues with a furan, thiophene, or thiazole ring were synthesized, and their inhibitory activities toward human cancer cell lines were evaluated. The analogues showed more potent activities than natural acetogenin. One of them, the thiophene-3-carboxamide analogue, strongly inhibited the growth of human lung cancer cell line NCI-H23 in the xenograft mouse assay without critical toxicity.


PMID: 25226228

DOI: 10.1016/j.ejmech.2014.09.026

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Mendes, M.; Ferreira, A.Carina.; Navarro, D.; Pinto, B.; Gomes, F.; Matias, Pícia.; Jorge, C.; Aires, Iês.; Ferreira, Aíbal., 2017: Optimizing the use of darbepoetin-α with a split strategy: a concept change
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Dalziel, J.E.; Anderson, R.C.; Bassett, S.A.; Lloyd-West, C.M.; Haggarty, N.W.; Roy, N.C., 2017: Influence of Bovine Whey Protein Concentrate and Hydrolysate Preparation Methods on Motility in the Isolated Rat Distal Colon. Whey protein concentrate (WPC) and hydrolysate (WPH) are protein ingredients used in sports, medical and pediatric formulations. Concentration and hydrolysis methods vary for whey sourced from cheese and casein co-products. The purpose of this res...

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