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Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats


, : Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats. Microvascular Research 80(3): 484-490

ACE inhibition has been shown to improve left ventricular (LV) and myocardial blood flow. Previous data regarding changes in capillary density and angiogenesis during ACE inhibition are controversial. The aim of the following study was to determine myocardial microcirculation and heart function in the rat after coronary stenosis using non invasive MR imaging techniques. MR spin labeling and cine techniques have been performed in female Wistar rats 2weeks after coronary artery stenosis. In one group, animals were treated with quinapril in a dose of 6mg/kg/day. Perfusion, relative blood volume (RBV), LV mass and function were determined non-invasively 2weeks after treatment. Finally, fibrosis and capillary density were analyzed histologically. Additionally, hemodynamic measurements were realized in a further group in order to calculate systemic vascular resistance (SVR). Quinapril resulted in a significant increase in perfusion at rest in the remote and the poststenotic myocardium with improved systolic function and a decrease in SVR compared to the non treated control group. Additionally, maximum perfusion and RBV were slightly elevated whereas capillary density was unchanged among the groups. MRI allows for non-invasive quantification of functional microcirculation and heart function. In addition to the well known effect of ACE inhibition on systolic function, treatment with the tissue specific ACE inhibitor quinapril revealed an important microvascular improvement, especially at arteriolar level. These findings may support the use of tissue ACE inhibitors to improve cardiac microcirculation after ischemia.

US$19.90

PMID: 20570682

DOI: 10.1016/j.mvr.2010.05.007


Other references

Löhr, B.; Jelke, G.; Schroeder, L., 1977: Prolaps of trachea as special form of asthma and its surgical correction from transcollar access. A new operative method of treatment of prolaps of pars membranacea in the region from trachea is reported. One cause of this prolaps is a false breathing mechanism, mainly without respiration through the nose. The reflection of pathogenesis of thi...

Garraway, J.L.; Cook, S.E., 1969: Factors affecting the systemic antifungal activity of some chemically related compounds. Some phenols, phenolic glycosides and derivatives of sulphanilic acid were tested for direct (in vitro) and systemic activity against some rust and mildew fungi. Results against Uromyces fabae are quoted. Some of the highly substituted phenols wer...

Haimi, Jari., 1993: Effects of earthworms on soil processes in coniferous forest soil. Biological Research Reports from the University of Jyvaskyla, 32: 70pp.

Brantl, Sabine, 2002: Antisense RNAs in plasmids: Control of replication and maintenance. The search for small RNAs which might act as riboregulators became successful over the past two years both in prokaryotes and in eukaryotes. Moreover, artificially designed antisense RNAs have become powerful tools to downregulate the expression o...

Fujimura Sadao, 1990: Evaluation of potential danger in case of earthquakes by using remote sensing. Butsuri-Tansa = Geophysical Exploration 43(6): 507-520

Contesso, G.; Bertin, F.; Terrier, P.; Petit, J.Y.; Le, M., 1991: What is "mastopathy at risk" for the anatomopathologist?. For the pathologist, the term "mastopathy at risk" comprises a double aspect. On one hand, a good definition of the boundary between benign lesions and cancer. The latter uses mainly, and still now, morphological signs, and no "mark...

Khaleque A.; Rahman A.; Rashid A., 1976: Studies on the preparation and properties of infant foods part 1 effect of pre processing conditions on the extractability of proteins and starch from bengal gram cicer arietinum. Bangladesh Journal of Scientific & Industrial Research 11(1-4): 103-108

Netlyukh M.A.; Nazar P.S.; Kovalishin V.I., 1981: Myo cardial ultrastructure in experimental thoracic aortic stenosis in dogs. Myocardium of the left ventricle of the heart was studied in 15 dogs with an experimental aortic stenosis and in 5 control dogs. It was demonstrated that 15-30 min after stenosis of the thoracic aorta, certain destructive changes occur, first of a...

Ohnishi, T.; Ishizaki, T.; Sasaki, F.; Ameshima, S.; Nakai, T.; Miyabo, S.; Matsukawa, S., 1997: The effect of Cu-2+ on rat pulmonary arterial rings. In the current study, Cu-2+ was tested for its ability to relax vessels and to accumulate cyclic GMP (cGMP) in rat pulmonary artery employing rat extrapulmonary arterial rings. Cu-2+-induced relaxation was endothelium and concentration (in the ran...

Mauersberger, G., 1991: Ein weiterer Fund des Monarchen Danaus chrysippus in Zentral-Tunesien (Lepidoptera, Danaidae). Deutsche Entomologische Zeitschrift, 384-5: 369-370