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Tissue-engineering of the gastrointestinal tract


, : Tissue-engineering of the gastrointestinal tract. Current Opinion in Pediatrics 24(3): 365-370

The purpose of this review is to describe recent advancements in tissue-engineering of the gastrointestinal system. For some patients, a congenital or acquired defect in the alimentary system results in digestive or nutritional deficiencies requiring intervention. Unfortunately, these treatments are associated with morbid complications. Advances in the growth of tissue-engineered esophagus, stomach, small intestine, colon and anus have been made in recent years. The progress reviewed here hopefully will someday benefit patients with gastrointestinal organ loss by providing a tissue replacement with morphology and function similar to native tissue. In native gastrointestinal tissue, epithelial homeostasis is governed largely by the interaction of the stem cell and its surrounding cellular niche. In particular, the small intestinal stem cell populations identified as the crypt base columnar cell (CBCC) and at cell position 4 (cp4) are responsible for mucosal maintenance and response to injury. This work influences efforts to generate bioengineered tissues for both in-vitro mucosal models and full-thickness in-vivo tissue-engineered esophagus, stomach, intestine and colon. Gastrointestinal organ loss is a challenge to manage. Current therapy can be life-saving, but is associated with morbid complications. Tissue-engineering will someday restore normal gastrointestinal function and eliminate the need for nutritional supplementation or transplant.

US$19.90

PMID: 22450251

DOI: 10.1097/MOP.0b013e328352ec19


Other references

Kitazawa, Y., 1976: Increased intraocular pressure induced by corticosteroids. Twelve patients who were highly responsive to topically administered betamethasone were subjected to various corticosteroid preparations (four times daily for four weeks). Each patient was tested in the same eye with fluorometholone, tetrahydrotri...

Zwane, E.N.; van Zyl, P.J.; Duodu, K.G.; Rose, S.H.; Rumbold, K.; van Zyl, W.H.; Viljoen-Bloom, M., 2017: Enrichment of maize and triticale bran with recombinant iAspergillus tubingensis ferulic acid esterase. Ferulic acid is a natural antioxidant found in various plants and serves as a precursor for various fine chemicals, including the flavouring agent vanillin. However, expensive extraction methods have limited the commercial application of ferulic a...

Havel, T.F.; Wüthrich, K., 1985: An evaluation of the combined use of nuclear magnetic resonance and distance geometry for the determination of protein conformations in solution. An evaluation of the potential of nuclear magnetic resonance (n.m.r.) as a means of determining polypeptide conformation in solution is performed with the aid of a new distance geometry program which is capable of computing complete spatial struct...

Prochazka, K.T.; Posch, F.; Deutsch, A.; Beham-Schmid, C.; Stöger, H.; Abdyli, L.; Greinix, H.; Pichler, M.; Neumeister, P., 2017: Immunohistochemical double hit score enhances NCCN-IPI and is associated with detrimental outcomes in refractory or relapsing patients with diffuse large B cell lymphoma. British Journal of Haematology

Wang Chien ying; Yeh Yeong tein; Lin Shu jen, 1989: Dispersion of waves across the SMART-1 array. Proceedings of the Geological Society of China 32(2): 179-195

Breder, C.M., 1936: Long-lived fishes in the Aquarium. Bulletin of the New York Zoological Society, 39: 116-117

Cappetta, H.; Stringer, G., 2002: A new batoid genus Neoselachii Myliobatiformes from the Yazoo Clay Late Eocene of Louisiana, USA. Tertiary Research. November; 211-4: 51-56

Cotterell, R., 1964: Breeding the Vinaceous Firefinch Lagonostica vinacea. Avicultural Magazine, 70: 106-108

Smirnov, A.M., 1966: Survival rate of the causative agents of European foul brood in bees in their environment and the resistance to physical-chemical factors. At various temperatures and relative humidity, Bacillus alvei and Streptococcus apis survived for the longest time on the test objects. The least resistant species was Bacterium pluton. The causative agents survived for the longest time on the sur...

Vincent J.S.; Kon H.; Levin I.W., 1987: Low temperature epr study of the ferricytochrome c cardiolipin complex. The electron paramagnetic resonance spectrum of the ferricytochrome c complex with cardiolipin was observed at temperatures below 20 K. For the low-spin iron(III) heme system complexed with the negatively charged lipid, the tetragonal and rhombic...