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Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach


, : Toxic polyketides produced by Fusarium sp., an endophytic fungus isolated from Melia azedarach. Bioorganic & Medicinal Chemistry Letters 21(6): 1887-1889

A new isocoumarin derivative named fusariumin (1), together with two known related resorcylic acid lactones aigialomycin D (2) and pochonin N (3), has been isolated from the cultures of Fusarium sp. LN-10, an endophytic fungus originated from the leaves of Melia azedarach. Their structures were established on the basis of extensive spectroscopic analyzes including 1D- and 2D- NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) experiments. Compounds 1-3 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina).

US$19.90

PMID: 21353539

DOI: 10.1016/j.bmcl.2010.12.043


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