+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence

, : Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. Bmc Neuroscience 12(): 2-2

Transcranial direct current stimulation (tDCS) is a technique that can systematically modify behaviour by inducing changes in the underlying brain function. In order to better understand the neuromodulatory effect of tDCS, the present study examined the impact of tDCS on performance in a working memory (WM) task and its underlying neural activity. In two experimental sessions, participants performed a letter two-back WM task after sham and either anodal or cathodal tDCS over the left dorsolateral prefrontal cortex (DLPFC). Results showed that tDCS modulated WM performance by altering the underlying oscillatory brain activity in a polarity-specific way. We observed an increase in WM performance and amplified oscillatory power in the theta and alpha bands after anodal tDCS whereas cathodal tDCS interfered with WM performance and decreased oscillatory power in the theta and alpha bands under posterior electrode sides. The present study demonstrates that tDCS can alter WM performance by modulating the underlying neural oscillations. This result can be considered an important step towards a better understanding of the mechanisms involved in tDCS-induced modulations of WM performance, which is of particular importance, given the proposal to use electrical brain stimulation for the therapeutic treatment of memory deficits in clinical settings.


PMID: 21211016

DOI: 10.1186/1471-2202-12-2

Other references

Andersen, A.N.; Sparling, G.P., 1997: Ants as indicators of restoration success: relationship with soil microbial biomass in the Australian seasonal tropics. Ants are widely used as bioindicators in Australian land assessment and monitoring programs, particularly in relation to ecosystem restoration following mining. Little is known, however, about the relationship between ant community development and...

Timmler, R.; Jeroch, H., 1993: Feed effect of rations with varying proportions of grass meal on selected parameters of slaughter quality of geese. From 5 to 16 weeks old, 96 hybrid geese were restricted fed with mixed diets containing 0, 5, 10 and 20% grass meal and metabolizable energy 11.8, 11.5, 11.1 and 10.5 MJ/kg (trial 1). In a second trial, 120 hybrid geese were freely given mixed sta...

Cohen, S.B.; Mashiach, M.D.litzky S.; Schiff, E., 1997: New birthweight normograms for twin gestation based on highly accurate gestational age. American Journal of Obstetrics & Gynecology 176(1 PART 2): S162

Mendez, D.L.; Mandt, R.E.; Elgin, S.C.R., 2013: Heterochromatin Protein 1a (HP1a) partner specificity is determined by critical amino acids in the chromo shadow domain and C-terminal extension. Drosophila melanogaster Heterochromatin Protein 1a (HP1a) is an essential protein critical for heterochromatin assembly and regulation. Its chromo shadow domain (CSD) homodimerizes, a requirement for binding protein partners that contain a PXVXL m...

Filippov, AG.; Tiunov, MP., 1999: Bat remains in caves of Irkutsk Region. Plecotus et al, 2: 100-107

Leboulanger, C.; Martin Jezequel, V.; Descolas Gros, C.; Sciandra, A.; Jupin, H.J., 1998: Photorespiration in continuous culture of Dunaliella tertiolecta Relationships between serine, glycine, and extracellular glycolate. The concentrations of extracellular glycolate and intracellular free pools of serine and glycine were monitored in nitrogen-limited continuous cultures of Dunaliella tertiolecta (Butcher) UTEX LB999, grown at two different irradiances on a light:d...

D'Acunto, C.; Raone, B.; Neri, I.; Passarini, B.; Patrizi, A., 2016: Outpatient pediatric dermatologic surgery: experience in 296 patients. From January 2010 to December 2012, 296 skin biopsies were performed in pediatric patients using only local anesthesia (cream and infiltration). The biopsies were divided into three groups: biopsies of skin neoplasms, biopsies of skin rashes and b...

Duignan, P.J.; Percy, D.H., 1992: Diagnostic exercise: unexplained deaths in recently acquired C3H3 mice. Laboratory Animal Science 42(6): 610-611

Wujcik, D., 1997: Future considerations in transplantation. Seminars in Oncology Nursing 13(3): 216-218

Xia, L.; Zhang, D.; Wang, C.; Wei, F.; Hu, Y., 2012: PC-PLC is involved in osteoclastogenesis induced by TNF-α through upregulating IP3R1 expression. The precise mechanism of how TNF-? promotes osteoclast formation is not clear. Previous reports show TNF-? targets molecules that regulate calcium signaling. Inositol-1,4,5-trisphosphate receptors (IP3Rs) are important calcium channel responsible...