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Transcriptional activities of histone H3, cyclin D1 and claudin 7 encoding genes in laryngeal cancer


, : Transcriptional activities of histone H3, cyclin D1 and claudin 7 encoding genes in laryngeal cancer. European Archives of Oto-Rhino-Laryngology 268(5): 709-714

Uncontrolled proliferation and a decrease in cell-cell adhesion are one of the most important characteristics of malignancy. Determination of replication-dependent histone H3 can be applied as a proliferative marker. Cyclin D1 (CCND1) regulates the cell cycle by participating in the control of the G1/S phase transition. Claudins (CLDN) are components of tight junctions and may play an essential role in the loss of tissue cohesion. The aim of the study was to assess the mRNA expression of histone H3, cyclin D1, and claudin 7 genes in laryngeal squamous cell carcinoma (LSCC) and adjacent nonneoplastic tissues. The study group consisted of 32 patients with LSCC. Adjacent nonneoplastic tissues of incision lines were used as controls. Quantification of H3, CCND1 and CLDN7 mRNAs was performed by the use of real-time QRT-PCR assay. Molecular analysis showed a significantly higher expression of CCND1 (P = 0.0001; Wilcoxon test) and H3 (P = 0.0141) genes in tumor tissues than in surrounding nonneoplastic tissues. On the contrary, transcriptional activity of claudin 7 gene was higher in histologically normal tissues; however, this difference was not statistically significant (P = 0.1499). The data obtained indicate that laryngeal cancer is characterized by high proliferative potential mediated by increase in cyclin D1 and H3 mRNAs expression.

US$19.90

PMID: 21193919

DOI: 10.1007/s00405-010-1471-0


Other references

van Stokkum, I.H.; Beekman, L.M.; Jones, M.R.; van Brederode, M.E.; van Grondelle, R., 1997: Primary electron transfer kinetics in membrane-bound Rhodobacter sphaeroides reaction centers: a global and target analysis. Absorbance difference kinetics were measured on quinone-reduced membrane-bound wild type Rhodobacter sphaeroides reaction centers in the wavelength region from 690 to 1060 nm using 800 nm excitation. Global analysis of the data revealed five lifet...

Gustavsson H.; Slunga E.; Saarelainen S., 1999: Finnish frost design concept of roads. Proceedings of the

Shim, S.C.; Yoo, D.H.; Lee, J.K.; Koh, H.K.; Lee, S.R.; Oh, S.H.; Kim, S.Y., 1998: Multiple cerebellar infarction due to vertebral artery obstruction and bulbar symptoms associated with vertical subluxation and atlanto-occipital subluxation in ankylosing spondylitis. Ankylosing spondylitis (AS) results in disease-specific inflammation at the site of ligamentous insertion into the bone. Atlantoaxial joint subluxation and vertical subluxation of the axis may occur as a consequence of instability resulting from t...

Benard, M., 1977: Automatic determination of specific gravity of liquids. Brewers digest: 52 (9) 64-66

Denys, P., 1955: Allergic pseudosepsis and Chauffard-Still disease. Acta Paediatrica Belgica 9(2): 57-68

Wada, M., 1968: Studies on cardiovascular abnormalities in hyperthyroidism patients with special reference to adrenergic beta-receptor. Sapporo Igaku Zasshi. Sapporo Medical Journal 33(6): 314-325

Waaland, Jr; Waaland, Sd; Bates, G., 1974: Chloroplast structure and pigment composition in the red alg a Griffithsia pacifica: regulation by light intensity. Journal of phycology: 10 (2) 193-199

Lindberg, B.; Carlsson, A.; Ericsson, V.B.; Ivarsson, S.A.; Lernmark, A., 1999: Prior exposure to measles, mumps, and rubella - but not vaccination during adolescence - correlates to the prevalence of pancreatic and thyroid autoantibodies. Hormone Research (Basel) 51(SUPPL 2): 138, Aug

Wiss, O.; Bettendorf, G., 1957: Conversion of 3-hydroxyanthranilic acid into cholinic acid & nicotinic acid in animal organism. II. Isolation and temporary characterisation of primary oxidation products of 3-hydroxyanthranilic acid. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 306(4-6): 145-153

Maercke, D.Van, 1973: Nitrogen fertilization and the nitrate content of spinach. In field trials with spring- and late summer-sown spinach N was applied at 100 or 200 kg/ha, and 75 or 150 kg/ha, respectively, as ammonium sulphate, calcium nitrate, crotonylidine diurea or urea. With spring-sown plants yields were greatly increa...