geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Trastuzumab for Her2/neu-positive metastatic salivary gland carcinoma: Case report and review of the literature


, : Trastuzumab for Her2/neu-positive metastatic salivary gland carcinoma: Case report and review of the literature. Avicenna Journal of Medicine 2(3): 71-73

Salivary gland carcinomas metastasize to distant organs in 20% of salivary gland malignancies. Applying immunohistochemistry (IHC) measures, salivary gland tumors showed a wide range of oncogene markers expression, including the human epidermoid receptor 2 (Her2/neu), which could be targeted with monoclonal antibody. Treating salivary gland tumors, which have Her2/neu over-expression, with trastuzumab was reported in a few case reports. We report a 61-year-old Caucasian male, with a history of salivary gland tumor, who presented after 20 years of complete surgical resection with kidney mass. He was treated as primary renal cell carcinoma, unclassified, with nephrectomy and adjuvant clinical trail where he received placebo. Subsequently, he developed multiple hepatic lesions and retroperitoneal mesenteric lymphadenopathy; CT-guided biopsy revealed adenocarcinoma with Her2/neu, 3+ by IHC. The patient was treated successfully with trastuzumab with near-complete response.

US$19.90

PMID: 23826550

DOI: 10.4103/2231-0770.102282


Other references

Desiato, R.; Baioni, E.; Cuttica, G.; Sparagna, B.; Berruto, P.; Abete, M.Cesarina.; Bertolini, S.; Maurella, C.; Caramelli, M.; Chiavacci, L.; Ru, G., 2013: Environmental micropollutants in livestock products from Susa Valley, Piedmont. to describe the contamination due to dioxins and dioxin-like PCBs of cattle dairy and meat products in cattle herds from Susa Valley (Piedmont) since the second half of 2004. descriptive study based on a biomonitoring campaign on bovine bulk milk...

Castellanos, A.; Aza, C.No.L.; Calvino, J.M.; Taquechel, N., 1957: Spatial vectorcardiography with resistance compensation; the Frank method. I. Normal subjects. Revista Cubana de Cardiologia 18(3-4): 157-174

Frank, A.R.; Petersen, R.C., 2008: Mild cognitive impairment. Handbook of Clinical Neurology 89: 217-221

Verzili, D.; Citro, G.; Ascoli, F.; Chiancone, F., 1985: Immunological properties of the dimeric and tetrameric hemoglobins from the mollusc Scapharca inaequivalvis. The dimeric and tetrameric hemoglobins from the bivalve mollusc Scapharca inaequivalvis produce highly specific antibodies in rabbits. No antigenic cross-reactivity between the two hemoglobins has been observed despite the presence of highly conse...

Sigal, E.I.; Potanin, V.P.; Khamidullin, R.G.; Dmitriev, E.G., 1994: First experience of thoracoscopic operations. Kazanskii Meditsinskii Zhurnal 75(6): 462-463

Ren, Y-Jun.; Zhang, L.; Bai, T.; Yu, H-Lu.; Li, Y.; Qian, W.; Jin, S.; Xiong, Z-Fan.; Wang, H.; Hou, X-Hua., 2017: Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. The role of low-grade inflammation in the development of post‑infectious irritable bowel syndrome (PI‑IBS) has attracted increasing attention. Abnormal CD11c+ mononuclear phagocytes, such as dendritic cells (DCs), macrophages, and monocytes,...

Jennings James R., 1973: The morphology and relationships of the genus Rhodea. American Journal of Botany 60(4, Supplement): 17

Overley, F.L., 1930: Relation of combination sprays to spray residue problems in Washington. On lead arsenate and oil residues on fruit.

Inoue, R.; Kato, T.; Kim, F.; Mizushima, I.; Murata, T.; Yoshino, H.; Kawano, M.; Yamagishi, M., 2013: A case of adult-onset Still's disease (AOSD)-like manifestations abruptly developing during confirmation of a diagnosis of metastatic papillary thyroid carcinoma. A 68-year-old Japanese man was admitted to our hospital suffering from abrupt onset of high fever accompanied by arthralgia, myalgia, sore throat, macular eruption, and liver dysfunction. Six months before the onset of these manifestations, <su...

Kukoba, T.V.; Moĭbenko, O.O.; Kotsioruba, A.V., 2004: Cardioprotective effect of heme oxygenase-1 induction by hemin on the isolated rat heart during ischemia--reperfusion. The aim of the study was to determine the role of both an inducible isoform of heme oxygenase (HO-1) and products of heme catabolism (carbon monoxide (CO), cardiac bilirubin and Fe2+) in protecting myocardium against post-ischemic myocardial dysfu...