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Treatment planning methods in high dose rate interstitial brachytherapy of carcinoma cervix: a dosimetric and radiobiological analysis


, : Treatment planning methods in high dose rate interstitial brachytherapy of carcinoma cervix: a dosimetric and radiobiological analysis. Isrn Oncology 2014: 125020-125020

Treatment planning is a trial and error process that determines optimal dwell times, dose distribution, and loading pattern for high dose rate brachytherapy. Planning systems offer a number of dose calculation methods to either normalize or optimize the radiation dose. Each method has its own characteristics for achieving therapeutic dose to mitigate cancer growth without harming contiguous normal tissues. Our aim is to propose the best suited method for planning interstitial brachytherapy. 40 cervical cancer patients were randomly selected and 5 planning methods were iterated. Graphical optimization was compared with implant geometry and dose point normalization/optimization techniques using dosimetrical and radiobiological plan quality indices retrospectively. Mean tumor control probability was similar in all the methods with no statistical significance. Mean normal tissue complication probability for bladder and rectum is 0.3252 and 0.3126 (P = 0.0001), respectively, in graphical optimized plans compared to other methods. There was no significant correlation found between Conformity Index and tumor control probability when the plans were ranked according to Pearson product moment method (r = -0.120). Graphical optimization can result in maximum sparing of normal tissues.

US$19.90

PMID: 24587919

DOI: 10.1155/2014/125020


Other references

Mandal, B.; Langston, D.B.J.; Pappu, H.R.; Beard, G.H.; Kucharek, T.A.; Flanders, J.T.; Whiddon, J.P.; Smith, J.E.; Kelley, W.T., 2001: First report of cabbage leaf curl virus (Family Geminiviridae) in Georgia. During the autumn of 2000, a virus-like disease was first observed to cause yellow spots, vein clearing, mosaic, curling and puckering in cabbage and collard green [kale] plants in Georgia, USA. Disease incidence ranged from 10 to 20% in the major...

Preston, S.J.; Roberts, D.; Montgomery, W.I., 1993: Shell scarring in Calliostoma zizyphinum from Strangford Lough, northern Ireland. Pink and white shells of Calliostoma zizyphinum show both undamaged and damaged scars. White shelled individuals predominate in Strangford Lough, Northern Ireland where Calliostoma densities and scarring levels are high. No white shells were found...

Mermigkis, C.; Stagaki, E.; Amfilochiou, A.; Polychronopoulos, V.; Korkonikitas, P.; Mermigkis, D.; Bregou, M.; Kouris, N.; Bouros, D., 2008: Sleep quality and associated daytime consequences in patients with idiopathic pulmonary fibrosis. The aim of this study was to describe sleep quality and associated daytime consequences in idiopathic pulmonary fibrosis (IPF). Fifteen patients with IPF and 15 control subjects matched on age and anthropometric variables were included in the stud...

Wofinden, R.C., 1952: The administrative problems of old age. Journal. Royal Sanitary Institute 72(5): 562-571

Quock R.M.; Mueller J., 1991: Involvement of 5 hydroxytryptamine 5 ht in mediation of nitrous oxide and u 50488h antinociceptive effects in mice. FASEB Journal 5(4): A859

ten Bokkel Huinink, W.W., 2000: The treatment of ovarian cancer has reached new standards of care. European Journal of Cancer 36(1): 7-9

Templer, Jc, 1977: Lets all stop talking %s. Tea in East Africa: 1 17-22

Natale, M.; Kanzler, M.; Jaffe, J.; Jaffe, J., 1980: Acute effects of alcohol on defensive and primary-process language. Results with three human volunteers. Alcohol was found to attenuate defensive aspects of speech. Contrary to expectations, primary-process language was shown to decrease by alcohol. These findings are congruent with previous studies which suggested alcohol not to activate specific mo...

Bohlmann, F.; Suwita, A.; Natu, A.A.; Czerson, H.; Suwita, A., 1977: Naturally occurring terpene derivatives part 106 on further alpha longipinene derivatives from composites. The investigation of further Stevia sp. afforded, besides known compounds, several new .alpha.-longipinene derivatives. From Tanacetum tanacetioides the basic compound, 1-oxo-.alpha.-longipinene, and a germacranolide were isolated. The structures...

Auer, J.; Hinterreiter, M.; Allinger, S.; Kirchgatterer, A.; Knoflach, P., 2000: Severe pancytopenia after leflunomide in rheumatoid arthritis. Leflunomide is a novel drug recently introduced for treatment of rheumatoid arthritis as a DMARD (disease-modifying antirheumatic drug). So far, leflunomide has not been associated with severe bone marrow toxicity and pancytopenia. We report of a...