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Tuberculosis contact investigation using interferon-gamma release assay with chest x-ray and computed tomography

, : Tuberculosis contact investigation using interferon-gamma release assay with chest x-ray and computed tomography. Plos One 9(1): E85612-E85612

Between September 2009 and January 2010, 6 members of the Japanese Eastern Army, who had completed the same training program, were diagnosed with active tuberculosis (TB) on different occasions. The Ministry of Defense conducted a contact investigation of all members who had come into contact with the infected members. The purpose of this study was to verify the efficacy of the TB screening protocol used in this investigation. A total of 884 subjects underwent interferon-gamma release assay (IGRA) and chest X-ray. The 132 subjects who were IGRA positive or with X-ray findings suggestive of TB subsequently underwent chest computer tomography (CT). Chest CT was performed for 132 subjects. Based on CT findings, 24 (2.7%) subjects were classified into the active TB group, 107 (12.1%) into the latent tuberculosis infection (LTBI) group, and 753 (85.2%) into the non-TB group. The first 2 groups underwent anti-TB therapy, and all 3 groups were followed for 2 years after treatment. Although one subject in the active TB group experienced relapse during the follow-up period, no patient in the LTBI or non-TB groups developed TB. IGRA and chest X-ray, followed by chest CT for those IGRA positive or with suspicious X-ray findings, appears to be an effective means of TB contact screening and infection prevention.


PMID: 24454900

DOI: 10.1371/journal.pone.0085612

Other references

Mckay, A.T., 1933: The distribution of VB1 in samples of four from a normal universe. The distribution is a sym-metrical curve having finite ordinates at the termini and an infinitely distant cusp on the axis of symmetry. This cannot be approximated to by a Pearson type curve. A sampling experiment suggests that for a rectangular u...

Pope, W., 2013: Reply: To PMID 21330401. Ajnr. American Journal of Neuroradiology 34(1): E12-E12

Paul, D.; Eckhardt, B., 1981: Fibula-pro-tibia surgery in the treatment of infected pseudarthrosis of the tibia. Zentralblatt für Chirurgie 106(4): 248-254

D'errico, G., 1950: Reconstruction of the continuity of the digestive tract following total gastrectomy by means of a segment of the transverse colon. Giornale Italiano di Chirurgia 6(4): 262-269

Dell, S.D.; Foty, R.; Becker, A.; Franssen, E.; Chapman, K.R., 2007: Parent-reported symptoms may not be adequate to define asthma control in children. Asthma guidelines have suggested that treatment decisions should be guided by indices of asthma control and not only by disease severity. In adults, symptom-based asthma control parameters have been shown to predict exacerbations and health care s...

Falcini, L.; Intropido, M.; Bisiach, M., 1980: New knowledge regarding the hypovirulence of Endothia parasitica and implications for the biological control of chestnut blight. Inoculation experiments on Castanea sativa showed that a reduction of virulence in normal strains of E. [Cryphonectria] parasitica is possible even when the fungus is not in contact with the hypovirulent strain, provided that the hypovirulent stra...

Nagato, T.; Ohkuri, T.; Ohara, K.; Hirata, Y.; Kishibe, K.; Komabayashi, Y.; Ueda, S.; Takahara, M.; Kumai, T.; Ishibashi, K.; Kosaka, A.; Aoki, N.; Oikawa, K.; Uno, Y.; Akiyama, N.; Sado, M.; Takei, H.; Celis, E.; Harabuchi, Y.; Kobayashi, H., 2017: Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy. Nasal natural killer/T-cell lymphoma (NNKTL) is an aggressive neoplasm with poor therapeutic responses and prognosis. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) pathway plays an important role in immune evasion of tumor cells th...

Tapernoux, A.; Magat, A.; Faure, N., 1964: Residues in the carcases of pigs given a supplement of Bifuran in the feed. Groups of 7 pigs were fattened from 20 kg liveweight for 130 days. The feed, with 13% protein, was given according to liveweight to a total of 3 kg daily in 2 feeds. It was given alone or with 0.02 or 0.10% Bifuran, a commercial coccidiostat with...

Leger, N.C.vier, R., 1970: Concerning the evolution of Hymenolepsis nana var. fraterna among rare intermediary hosts. Annales de parasitologie humaine et comparee: 45 (2) 195-201

Switzer, G.L.; Moehring, D.M.; Terry, T.A., 1979: Clearcutting vs. alternative timber harvesting-stand regeneration systems: effects on soils and environment of the south. A review.