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Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease


, : Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. Journal of Biological Chemistry 286(20): 17879-17888

Fine-tuning of host cell responses to commensal bacteria plays a crucial role in maintaining homeostasis of the gut. Here, we show that tumor necrosis factor receptor-associated factor (Traf)2(-/-) mice spontaneously developed severe colitis and succumbed within 3 weeks after birth. Histological analysis revealed that apoptosis of colonic epithelial cells was enhanced, and B cells diffusely infiltrated into the submucosal layer of the colon of Traf2(-/-) mice. Expression of proinflammatory cytokines, including Tnfa, Il17a, and Ifng, was up-regulated, whereas expression of antimicrobial peptides was down-regulated in the colon of Traf2(-/-) mice. Moreover, a number of IL-17-producing helper T cells were increased in the colonic lamina propria of Traf2(-/-) mice. These cellular alterations resulted in drastic changes in the colonic microbiota of Traf2(-/-) mice compared with Traf2(+/+) mice. Treatment of Traf2(-/-) mice with antibiotics ameliorated colitis along with down-regulation of proinflammatory cytokines and prolonged survival, suggesting that the altered colonic microbiota might contribute to exacerbation of colitis. Finally, deletion of Tnfr1, but not Il17a, dramatically ameliorated colitis in Traf2(-/-) mice by preventing apoptosis of colonic epithelial cells, down-regulation of proinflammatory cytokines, and restoration of wild-type commensal bacteria. Together, TRAF2 plays a crucial role in controlling homeostasis of the colon.

US$19.90

PMID: 21393251

DOI: 10.1074/jbc.M111.221853


Other references

Hong; Mandel, 1985: Higher-order squeezing of a quantum field. Physical Review Letters 54(4): 323-325

Lindner, G., 1896: Studien uber die Biologie parasitischer Vorticellen. Biologisches Zentralblatt, XVI 610-624

Anonymous, 1978: Agricultural planning and management techniques in Yugoslavia. An experiment undertaken in the Province of Voivodina as part of the OECD Co-operative Action Programme. Part One of the Report deals with specific features of the socio-political background and organization of the agricultural sector, under the headings: I. General features of the socio-political background and place of Voivodina agriculture; II. Or...

Sandral, G.A.; Dear, B.S.; Pratley, J.E.; Cullis, B.R., 1997: Herbicide dose rate response curves in subterranean clover determined by a bioassay. Herbicide dose response curves were developed for 5 herbicide treatments, MCPA, 2,4-DB, bromoxynil, MCPA + terbutryn and MCPA + diuron, when applied to 2 cultivars of subterranean clover (Trifolium subterraneum L.) in a glasshouse experiment. The...

Esson J.; Surcan dos Santos L.C., 1978: The occurrence, mineralogy and chemistry of some garnierites from Brazil. Bulletin du Bureau de Recherches Geologiques et Minieres, Section 2: Geologie Appliquee, Chronique des Mines: ges 263-274. 1978.

Abdulla Yusuf, H.; Baldock, S.J.; Barber, R.W.; Fielden, P.R.; Goddard, N.J.; Mohr, S.; Treves Brown, B.J., 2009: Optimisation and analysis of microreactor designs for microfluidic gradient generation using a purpose built optical detection system for entire chip imaging. This paper presents and fully characterises a novel simplification approach for the development of microsystem based concentration gradient generators with significantly reduced microfluidic networks. Three microreactors are presented; a pair of t...

Depickere, S.; Fresneau, D.; Deneubourg, J.L., 2004: A basis for spatial and social patterns in ant species: dynamics and mechanisms of aggregation. Aggregation is usually studied in functional terms, forgetting mechanisms. In this paper, experimental results on the ant Lasius niger, complemented by a model, allow us to understand the mechanisms responsible for aggregation and to study the inf...

Meyer, C.J.; Layne, D.S.; Tait, J.F.; Pincus, G., 1961: The binding of aldosterone to plasma proteins in normal, pregnant, and steroid-treated women. The percentage binding of physiological amounts of 7-H3-aldosterone to undiluted plasma of normal women after dialysis against 5% human serum albumin was 16.4[plus or minus]2.2 (SE). Corresponding values for late pregnancy plasma were 17[plus or m...

Anonymous, 1985: OCs are currently the second most popular birth control method in U.S. Recent information concerning oral contraceptive (oc) usage in the US is summarized. Currently, 10 million in the US, 20 million women in developed countries, and 56 million women throughtout the world use OCs. According to the Cycle iii National...

Umeki, K., 2005: Mutations of the thyroid peroxidase gene. Nihon Rinsho. Japanese Journal of Clinical Medicine 63 Suppl 10: 24-29