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Unlinked memory helper responses promote long-lasting humoral alloimmunity


, : Unlinked memory helper responses promote long-lasting humoral alloimmunity. Journal of Immunology 189(12): 5703-5712

Essential help for long-lived alloantibody responses is theoretically provided only by CD4 T cells that recognize target alloantigen, processed and presented by the allospecific B cell. We demonstrate that in an alloresponse to multiple MHC disparities, cognate help for class-switched alloantibody may also be provided by CD4 T cells specific for a second "helper" alloantigen. This response was much shorter-lived than when help was provided conventionally, by Th cell recognition of target alloantigen. Nevertheless, long-lasting humoral alloimmunity developed when T cell memory against the helper alloantigen was first generated. Costimulatory blockade abrogated alloantibody produced through naive Th cell recognition of target alloantigen but, crucially, blockade was ineffective when help was provided by memory responses to the accessory helper alloantigen. These results suggest that memory Th cell responses against previously encountered graft alloantigen may be the dominant mechanism for providing help to generate new specificities of alloantibody in transplant patients receiving immunosuppression.

US$19.90

PMID: 23162131

DOI: 10.4049/jimmunol.1202257


Other references

Joysey Kenneth Alan, 1959: Probable cirripede, phoronid, and echiuroid burrows within a Cretaceous echinoid test. Describes burrows within the test of a single echinoid (Echinocorys) found in beach material derived from Cretaceous Chalk cliffs of the Isle of Wight, southern England. "It is concluded that they indicate the probable presence of an acrothor...

Szubert Z.; Wilczynska U., 1991: Sickness absenteeism as a measure of health condition in groups of long and frequently ailing persons. Results of the feasibility analysis of using sickness absenteeism as a measure of worker health condition, especially in long (above 30 days p.a.) and often (above 3 cases p.a.) ailing workers have been reported. Information on health condition of...

Malli, C.; Sioulas, A.D.; Dimitriadis, G.D.; Triantafyllou, K., 2015: Unexpected drainage of pancreatic pseudocyst through the common bile duct. Annals of Gastroenterology 28(1): 156-156

Jephcott, A.E., 1986: Epidemiology of resistance in Neisseria gonorrhoeae. In the face of almost unique selective pressures many strains of gonococci have become increasingly resistant to antibiotics. Both chromosomal mutation and acquisition of plasmids are involved. However, whereas there have probably been multiple se...

Shimmield G.B.; Ritchie G.D., 1991: The impact of water mass movement and productivity on (super 210) Po/ (super 210) Pb disequilibrium in the Northeast Atlantic. Eos, Transactions, American Geophysical Union 72(51, Suppl

Donoghue, O.A.; Jansen, S.; Dooley, C.; D.R.oij, S.; Van Der Velde, N.; Kenny, R.Anne., 2015: Atrial fibrillation is associated with impaired mobility in community-dwelling older adults. To examine the independent associations between atrial fibrillation (AF) and objectively measured mobility in a nationally representative cohort. Wave 1 of The Irish Longitudinal Study on Ageing (TILDA), a population-based study assessing health,...

Gross, G.J.; Daemmgen, J.W., 1987: Effects of bradycardic agents on ischaemic myocardium and perfusion in anesthetized dogs. The effects of several new specific bradycardic agents, AQ-A39 and AQ-AH 208, were evaluated in two models of myocardial ischaemia in anesthetized dogs. In the first model, equal bradycardic doses of AQ-AH 208 and propranolol were compared for the...

Lee, T.H.; Bolontrade, M.F.; Worth, L.L.; Guan, H.; Ellis, L.M.; Kleinerman, E.S., 2006: Production of VEGF165 by Ewing's sarcoma cells induces vasculogenesis and the incorporation of CD34+ stem cells into the expanding tumor vasculature. The Ewing's sarcoma cell line TC71 overexpresses vascular endothelial growth factor isoform 165 (VEGF(165)), a potent proangiogenic molecule that induces endothelial cell proliferation, migration and chemotaxis. CD34(+) bone marrow stem cells...

Havranek, F., 1954: Reliability of biological hyperemic tests and Galli-Mainini tests for early pregnancy, and clinical experiences. Prakticky Lekar 34(12): 282-284

Xiao, F-Xing.; Zeng, Z.; Hsu, S-Hui.; Hung, S-Fu.; Chen, H.Ming.; Liu, B., 2015: Light-Induced In Situ Transformation of Metal Clusters to Metal Nanocrystals for Photocatalysis. In situ transformation of glutathione-capped gold (Aux) clusters to gold (Au) nanocrystals under simulated solar light irradiation was achieved and utilized as a facile synthetic approach to rationally fabricate Aux/Au/TiO2 ternary and Au/TiO2 bin...