geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Validation of a molecular and pathological model for five-year mortality risk in patients with early stage lung adenocarcinoma


, : Validation of a molecular and pathological model for five-year mortality risk in patients with early stage lung adenocarcinoma. Journal of Thoracic Oncology 10(1): 67-73

The aim of this study was to validate a molecular expression signature [cell cycle progression (CCP) score] that identifies patients with a higher risk of cancer-related death after surgical resection of early stage (I-II) lung adenocarcinoma in a large patient cohort and evaluate the effectiveness of combining CCP score and pathological stage for predicting lung cancer mortality. Formalin-fixed paraffin-embedded surgical tumor samples from 650 patients diagnosed with stage I and II adenocarcinoma who underwent definitive surgical treatment without adjuvant chemotherapy were analyzed for 31 proliferation genes by quantitative real-time polymerase chain reaction. The prognostic discrimination of the expression score was assessed by Cox proportional hazards analysis using 5-year lung cancer-specific death as primary outcome. The CCP score was a significant predictor of lung cancer-specific mortality above clinical covariates [hazard ratio (HR) = 1.46 per interquartile range (95% confidence interval = 1.12-1.90; p = 0.0050)]. The prognostic score, a combination of CCP score and pathological stage, was a more significant indicator of lung cancer mortality risk than pathological stage in the full cohort (HR = 2.01; p = 2.8 × 10) and in stage I patients (HR = 1.67; p = 0.00027). Using the 85th percentile of the prognostic score as a threshold, there was a significant difference in lung cancer survival between low-risk and high-risk patient groups (p = 3.8 × 10). This study validates the CCP score and the prognostic score as independent predictors of lung cancer death in patients with early stage lung adenocarcinoma treated with surgery alone. Patients with resected stage I lung adenocarcinoma and a high prognostic score may be candidates for adjuvant therapy to reduce cancer-related mortality.

US$19.90

PMID: 25396679

DOI: 10.1097/JTO.0000000000000365


Other references

Kolar, O.; Musil, J., 1966: The pneumomediastinographic results obtained in cases of subacute Dawson-Pette -Doering -van Bogaert encephalitis. The thymus hyperplasia in 3 patients with subacute Dawson-Pette-Doering-van Bogaert encephalitis was indicated. The thymus hyperplasia probably is connected with the development of the complex, immunopathological mechanisms.

L.H.oGen; Huang MinRen, 1999: The relationship between crown characteristics and stemwood growth of new poplar clones. The relationship between crown characteristics and stemwood growth was explored for 12 five-year-old poplar [Populus] hybrid F1 clones growing in [Fujian Province] China. The stemwood volume growth (Dsuperscript 2H, where D = diameter at breast he...

Zeilig, G.; Enosh, S.; Rubin-Asher, D.; Lehr, B.; Defrin, R., 2012: The nature and course of sensory changes following spinal cord injury: predictive properties and implications on the mechanism of central pain. Central pain below the injury level after spinal cord injury is excruciating, chronic and resistive to treatment. Animal studies suggest that pretreatment may prevent central pain, but to date there are no measures to predict its development. Our...

Ohlsson B., 1988: Mixing of acrylic bone cement. Acta Orthopaedica Scandinavica 59(3): 347-348

Morita, Y.; Nishii, O.; Kido, M.; Tsutsumi, O., 2000: Parvovirus infection after laparoscopic hysterectomy using fibrin glue hemostasis. Obstetrics and Gynecology 95(6 Pt 2): 1026-1026

van der Valk, R.; Schouten, J.S.A.G.; Webers, C.A.B.; Hendrikse, F.; Prins, M.H., 2006: Changes in glaucoma treatment and achieved IOP after introduction of new glaucoma medication. Purpose: To describe changes in glaucoma treatment and achieved IOP (intraocular pressure) over the period 1995-2002, 4 years before and 4 years after new glaucoma drugs had become available (January 1999). Methods: An observational study was cond...

Harris, S.; Cook, E., 1993: Aerobic decomposition of various cellulosic sample types in land disposal. Proceedings of the Industrial Waste Conference7(47): 461-471

Biesiot, P.M.; Wang, S.Y.; Perry, H.M.; Trigg, C., 1997: Organic reserves in the midgut gland and fat body of the giant deep-sea isopod bathynomus gigante. American Zoologist 37(5): 84A

Kerschbaumer, F., 1997: Quality standards in the surgical treatment of rheumatoid arthritis. The result of the surgical management in RA patients depends greatly on the following factors: Defining the specific problem of the patient - examination of, and advice given to, the patient - surgical intervention - evaluation of the result. It i...

Galanter, C.A., 2013: Limited support for the efficacy of nonpharmacological treatments for the core symptoms of ADHD. American Journal of Psychiatry 170(3): 241-244