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Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activity


, : Validation of the Lewis score for the evaluation of small-bowel Crohn's disease activity. Endoscopy 47(4): 330-335

The Lewis score was developed to measure mucosal inflammatory activity as detected by small-bowel capsule endoscopy (SBCE). The aim of the current study was to validate the Lewis score by assessing interobserver correlation and level of agreement in a clinical setting. This was a retrospective, single-center, double-blind study including patients with isolated small-bowel Crohn's disease who underwent SBCE. The Lewis score was calculated using a software application, based on the characteristics of villous edema, ulcers, and stenoses. The Lewis score was independently calculated by one of three investigators and by a central reader (gold standard). Interobserver agreement was assessed using intraclass correlation (ICC) coefficient and Bland - Altman plots. A total of 70 patients were consecutively included (mean age 33.9 ± 11.7 years). The mean Lewis score was 1265 and 1320 for investigators and the central reader, respectively. There was a high correlation, both for scores obtained for each tertile (first tertile r = 0.659 - 0.950, second tertile r = 0.756 - 0.906, third tertile r = 0.750 - 0.939), and for the global score (r = 0.745 - 0.928) (P < 0.0001). Interobserver agreement was almost perfect between the investigators and the central reader (first tertile ICC = 0.788 - 0.971, second tertile ICC = 0.824 - 0.943, third tertile ICC = 0.857 - 0.968, global score ICC = 0.852 - 0.960; P < 0.0001). The inflammatory activity was classified as normal (score < 135) in 2.9 % vs. 2.9 %, mild (score ≥ 135 - < 790) in 51.4 % vs. 55.7 %, and moderate to severe (score ≥ 790) in 45.8 % vs. 41.4 % of patients, respectively (P < 0.001). A strong interobserver agreement was demonstrated for the determination of the Lewis score in a practical clinical setting, validating this score for the reporting of small-bowel inflammatory activity. The Lewis score might be used for diagnosing, staging, follow-up, and therapeutic assessment of patients with isolated small-bowel Crohn's disease.

US$19.90

PMID: 25412092

DOI: 10.1055/s-0034-1390894


Other references

Geffard, M.; Kah, O.; Chambolle, P.; L.M.al, M.; Delaage, M., 1982: 1st immunocytochemical application of an anti-dopamine antibody in the study of the central nervous system. An antibody against dopamine was raised in Rabbits by means of an immunogen constituting dopamine coupled to bovine serum albumin by formaldehyde. These antibodies were applied to frozen sections of Goldfish (Carassius auratus) brain fixed by 4% p...

Derechin M.; Pragay D.A., 1982: Continuous automatic system for testing the serum fluorescent sugar interaction for cancer detection studies. Clinical Biochemistry 15(2): 95

Sun, Q.; Yao, Y.; Liu, C.; Li, H.; Yao, H.; Xue, X.; Liu, J.; Tu, Z.; Jiang, S., 2013: Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry. We report the design, synthesis, and biological evaluation of a new series of HDAC1 inhibitors using click chemistry. Compound 17 bearing a phenyl ring at meta-position was identified to show much better selectivity for HDAC1 over HDAC7 than SAHA....

Oakland, C.D.; Britton, J.M.; Charlton, C.A., 1987: Renal trauma and the intravenous urogram. A retrospective analysis of all patients with blunt abdominal trauma associated with haematuria admitted to one hospital (Royal United, Bath) in a 10-year period was conducted to establish the contribution of the intravenous urogram (IVU) in their...

Evans, M.J.; Smith-Jones, P.M.; Wongvipat, J.; Navarro, V.; Kim, S.; Bander, N.H.; Larson, S.M.; Sawyers, C.L., 2011: Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen. Despite encouraging clinical results with next generation drugs (MDV3100 and abiraterone) that inhibit androgen receptor (AR) signaling in patients with castration-resistant prostate cancer (CRPC), responses are variable and short-lived. There is...

Lindstrom G.U.M.; Johansson E.; Nygren M., 1985: Quality assurance of multivariate analytical measurements by principal components analysis. The use of principal components analysis for the quality control of a mass spectrometer is demonstrated and commented upon. [The use of mass spectrometry in the environmental pollutants polychlorinated dibenzo-p-dioxin and dibenzofurans.].

Tramier, R.; Mercier, S., 1963: Principal diseases of Gladiolus. A popular article outlining disease symptoms, conditions favouring the development of the pathogens, and control recommendations against Fusarium oxysporum f.sp. gladioli, Stromatinia gladioli, Septoria gladioli, Botrytis gladiolorum, and Pseudomo...

Koshiba, T.; Van Damme, B.; Lu, Y.; Yan, Y.; Rutgeerts, O.; Overbergh, L.; Tanaka, K.; Waer, M.; Mathieu, C.; Pirenne, J., 2002: Combined use of FTY720 and cyclosporine A prevents chronic allograft vasculopathy. Transplantation Proceedings 34(3): 748-749

Cheeseman C.I.; Tsang R.; A.Z., 1992: The influence of vascular and lumenal hexoses on rat isolated intestinal basolateral membrane glucose transport. Journal of Physiology (Cambridge) 452: 333P

Joshi, B.B.; Chaudhari, S.S., 1971: Intravenous regional antibiotic perfusion as prophylaxis against infection in injured hands. Indian Journal of Medical Sciences 25(6): 392-394