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Value of frozen section examination in diagnosis and treatment of high-grade cervical intraepithelial neoplasia


, : Value of frozen section examination in diagnosis and treatment of high-grade cervical intraepithelial neoplasia. Chinese Medical Journal 125(14): 2462-2465

Invasive cancer of the cervix is considered a preventable disease because it has a long pre-invasive state, cervical cytology screening programs are currently available, and treatment of pre-invasive lesions is effective. We tested the accuracy of frozen section examination (FSE) of cone specimens to identify the endocervical margin and rule out invasion in patients with high-grade cervical intraepithelial neoplasia (CIN). For 320 consecutive patients with a preoperative biopsy result of CIN stage 2/3, cold-knife conization (CKC) was performed followed by FSE. The results from analyses of permanent paraffin sections (PS) were compared with the FSE findings. The accuracy of FSE was 87% (278/320). For all of the seven patients with an invasive squamous cell carcinoma of the cervix identified by FSE, the diagnosis was confirmed by PS analysis. For one patient, the FSE result was cervicitis, whereas PS analysis showed microinvasive carcinoma. Appropriate surgery was performed for all patients based on the FSE and biopsy results. The FSE and PS results were not significantly different (P = 0.000). Definitive examination of margin status using PS was concordant with FSE findings in all cases. FSE is a rapid and reliable method for evaluating CKC specimens. It can identify frank invasion, permit adequate treatment in a one-stage procedure, and reliably detect clear resection margins. Since discrepancies do exist and may result in inappropriate treatment, further research is required to decrease these discrepancies and avoid missing even one case.

US$29.90

PMID: 22882922


Other references

Knorre, D.G.; Mishenina, G.F.; Shubina, T.N., 1976: The reactivity of di nucleotides bearing a protected inter nucleotide phosphate group in oligo nucleotide synthesis. The activation of dideoxynucleotides, which have a protected internucleotide phosphate group, in the presence of triisopropylbenzenesulfonyl chloride was investigated by 31P-NMR. As exemplified with pTp(CNEt)T(Ac), the final product of the convers...

Levitan, M.C.; Marco, O.P., 1976: Intestinal microflora in patients with Crohn's disease and ulcerative colitis. American Journal of Proctology 27(6): 49-54

Watanuki, M.; Nakamura, T.; Ogawa, M., 1996: Therapy of respiratory tract diseases using basic fibroblast growth factor. Official Gazette of the United States Patent & Trademark Office Patents 1186(1): 430, May 7

Nickerson, K.W.; D.P.nto, J.; Bulla, L.A., 1975: Lipid metabolism during bacterial growth, sporulation, and germination: kinetics of fatty acid and macromolecular synthesis during spore germination and outgrowth of Bacillus thuringiensis. The timing and kinetics of fatty acid synthesis are delineated for Bacillus thuringiensis spore germination and outgrowth by analyzing [U-14C]acetate and [2-3H]glycerol incorporation into chloroform-methanol-extractable and trichloroacetic acid-pr...

Santos, A.; Malta, T.; Mundim, A.; Alves Junior, J.; Carvalho, S., 2005: Variacao dos constituintes bioquimicos sanguineos de Tartarguas-da-Amazonia (Podocnemis expansa, Schweigger - 1812) (Testudinata) mantidas em criatorio comercial. The aim of the present research was to evaluate the biochemistry of blood constituents from the South American River Turtle Podocnemis expansa, Schweigger - 1912. For this experiment, 46 animals from Moenda do Lago Farm, a commercial farm from Sao...

Briese E., 1970: The hypothalamus as seen through the prism of diabetes mellitus. Acta Cientifica Venezolana 21(SUPPL 2): 25-26

West, Erdman, 1945: Notes on Florida fungi. III. Notes on the occurrence in Florida of 36 spp. of fungi in various groups are listed as new to the State, several new to the U. S. Three new spp. of parasitic Fungi Imperfecti are described: Cercospora forestierae on For-estiera acuminata; Sirosper...

Mattson,N.S.; Lieth,J.H.; ChoiGyeongLee; KimWanSoon, 2008: Changes in root surface area, nutrient absorption activity, and root carbohydrate concentration during crop cycles of Rosa hybrida Kardinal plants grown in solution culture. Cut flower rose production is often managed to produce a flush of harvestable flowers in time for particular holiday. Such crops go through cycles of vegetative and reproductive growth. Cyclical patterns of nutrient absorption are generally shifte...

Tan, L.; Zhang, X-Feng.; Yan, B-Zhen.; Shi, H-Ming.; Du, L-Bo.; Zhang, Y-Zhou.; Wang, L-Fen.; Tang, Y-Lin.; Liu, Y., 2007: A novel flavonoid from Lespedeza virgata (Thunb.) DC.: structural elucidation and antioxidative activity. Bioactivity guided fractionation of the ethanolic extract of the whole plants of Lespedeza virgata (Thunb.) DC. resulted in the isolation of a novel flavonoid (1) along with five known compounds 2-6. The molecular and structural formula as well as...

Mak, T.W.; Rutledge, G.; Sutherland, D.J., 1976: Androgen-dependent fibrinolytic activity in a murine mammary carcinoma (Shionogi SC-115 cells) in vitro. Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured eithe...