geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Variations of serum levels of adiponectin and resistin in chronic viral hepatitis


, : Variations of serum levels of adiponectin and resistin in chronic viral hepatitis. Journal of Endocrinological Investigation 36(8): 600-605

Several studies investigated the possible role of adipokines during chronic viral hepatitis, not producing defined results neither clearly establishing their behavior in course of anti-viral treatment. Our study evaluated blood concentrations of adiponectin and resistin in patients with chronic hepatitis C (CHC), B (CHB), and D (CHD) receiving anti-viral treatment, at baseline and after therapy. We examined 122 subjects, divided into two groups: 64 patients with chronic hepatitis C virus (HCV) infection (38 males and 26 females, mean age 47.25 yr) and 58 patients including 39 ones with chronic hepatitis B virus (HBV) infection (26 males and 13 females, mean age 48.46 yr) and 19 ones with chronic HBV-hepatitis D virus (HDV) infection (15 males and 4 females, mean age 45.79 yr). Serum levels of adiponectin and resistin were assayed by enzyme-linked immunosorbent assay. In the group of CHC patients we observed a significant decrease in resistin after therapy (p=0.006), while not a significant increase in adiponectin after treatment (p=0.32). Evaluation of changes in adiponectin and resistin levels after anti-viral treatment, both in responders and non-responders, revealed no significant variations. In the group of HBV+ and HBV-HDV+ patients, we found a decrease in resistin after therapy (p=0.0016) and a not significant reduction in adiponectin after treatment (p=0.13). Furthermore, we noticed a significant reduction of resistin (p=0.006) in the sub-group of responders. Our data suggested the possible marker role of adiponectin and resistin in the inflammatory process in course of chronic viral hepatitis.

US$19.90

PMID: 23449040

DOI: 10.3275/8883


Other references

Tsuda, M.; Tsuda, T.; Hiratsuka, T., 1990: Characterization of octopus photoreceptor G-proteins by bacterial toxins and fluorescence labeled GTP analog. Neuroscience Research. Supplement 12: S135-S144

Loiseleur Bernard, 1997: Genesis of the Soulages Depression (Causse de Sauveterre); a new explanation. The north part of the large Causses region (Causse de Sauveterre and Causse de Severac) presents some volcanic phenomena which affect the Jurassic sedimentary mantle. They are lined up from west to east, along some faults, the main one is the Vign...

Chuang, S.H., 1962: The sex ratio in cultures of Rhabditis teres (A. Schneider). Rhabditis teres (Schneider, 1866)=Peladera teres Schneider, 1866 was cultured in 0.6% earthworm-broth-agar used in 40% and 60% dilutions. The cultures were maintained in dim diffuse light between 13 and 25 degrees C. ; R. teres thrived only in cul...

Rudeĭko, V.A.; Trubko, E.I.; Tepliakova, E.V., 1983: Hygienic standards for alkylaminopropionitrile (AHC17-C20) applicable to the sanitary protection of reservoirs. Gigiena i Sanitariia: 82-84

Dias, Tísa.Silva.; Moysés Neto, M.; da Costa, Jé.Abrão.Cardeal., 2008: Arteriovenous fistula puncture: an essential factor for hemodialysis efficiency. To determine the blood recirculation ratio in the vascular access of patients on hemodialysis, and to calculate the Kt/Vs obtained with the different techniques of arteriovenous fistula punctures. A total of 174 patients were divided according to...

Topalov, V., 1969: The new lavender variety Venec. A selection from a local Lavandula vera population in Plovdiv district, Venec has higher yields of inflorescences and essential oil than the local population. Its essential oil contains more linalyl acetate than that of the population and has the...

Piferrer, F.C.; Callard, G.V., 1995: Inhibition of deoxyribonucleic acid synthesis during premeiotic stages of spermatogenesis by a factor from testis-associated lymphomyeloid tissue in the dogfish shark (Squalus acanthias). To investigate factors controlling spermatogonial proliferation, we used premeiotic (PrM) spermatocysts (stage-synchronized germ cell/Sertoli cell clones) derived from the testis of the dogfish shark (Squalus acanthias) as an in vitrotest system t...

Bouvier, E.L., 1904: Sur les organes genitaux males du Peripatus tholloni Bouv. Bulletin de la Societe Entomologique de France, 192 & 193

Ehle, G.; Ott, J.; Wahlstab, A., 1982: Value of group psychotherapy in the complex therapy of schizophrenic patients. Sammlung Zwangloser Abhandlungen aus dem Gebiete der Psychiatrie und Neurologie 50: 243-249

Martens D.C.; Gunaratne W.D.L.; Gettier S.W.; Tierney C.E., 1984: Response of soybeans glycine max to broadcast and foliar application of manganese. A field experiment was conducted for 2 growing seasons on a Dragston fine sandy loam (Aeric Ochraquults; coarse-loamy, mixed, thermic) to evaluate the effectiveness of broadcast and foliar procedures for correction of Mn deficiency in 2 cultivars...