geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention


, : Vascular and psychosocial factors in Alzheimer's disease: epidemiological evidence toward intervention. Journal of Alzheimer's Disease 20(3): 689-697

Alzheimer's disease (AD), the most common cause of dementia, is posing serious threat to public health and health care system in both developed and developing nations due to a rapid increase in the aging population. Identification of etiological factors for AD and active implementation of interventions targeting those modifiable factors that may prevent or postpone clinical onset of the dementing disorder will provide an opportunity to cope with this challenge. Multidisciplinary research involving epidemiology, neuropathology, and neuroimaging has provided moderately strong evidence supporting the role of vascular factors and related disorders (e.g., midlife high blood pressure and obesity, diabetes, cerebral microvascular lesions, and smoking) as risk factors and the possible role of psychosocial factors (e.g., high educational achievements, mentally-stimulating activity, social engagement, and physical exercise) as protective factors in the development and clinical manifestation of the dementia syndrome, including AD. The implementation of long-term, multidomain interventions designed for the modification of multiple vascular risk factors and the maintenance of socially-integrated lifestyles and mentally-stimulating activities is expected to postpone the clinical onset of AD and dementia, and thus, substantially reduce the burden of the disease at both the individual and societal levels.

US$19.90

PMID: 20182015

DOI: 10.3233/JAD-2010-091663


Other references

Sluyterman, L.A., 1967: Reversible inactivation of papain by cyanate. Low concentrations of KCNO (approx. 0. 1 m[image]) were found to react rapidly with activated papain (EC 3. 4. 4. 10), leading to inactivation of the enzyme. The re-action proved to be reversible, the activity slowly returning again on sufficient...

Pagliarini, E.; Bertuccioli, M.; Abba, S., 1994: Consumer attitudes and olive oil acceptance: The traditional consumer. In order to investigate extra virgin olive oil acceptance, preference tests were carried out on two olive oil consumer groups, representative of two different cultures and traditions. The first consumer group consisted of 20 South Italian families...

Threefoot, S.A., 1960: Some chemical, physical and biologic characteristics of dyes used to visualize lymphatics. Characteristics of dyes used to study lymphatics and other biologic systems can be of significance in quantification and interpretation of data. For example, determination of concentration is influenced by changes in spectral characteristics of so...

Greenland, K.B., 2015: Disposable C-MAC(®) videolaryngoscope blade - not the same as the re-usable blade. Anaesthesia 69(12): 1402-1403

Wells, A.H., 1975: Asbestos in Duluth water. Minnesota Medicine 58(6): 458-459

Wall, G.C.; Bryant, G.A.; Bottenberg, M.M.; Maki, E.D.; Miesner, A.R., 2015: Irritable bowel syndrome: a concise review of current treatment concepts. Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology a...

Lusignan, S.; Sismanidis, C.; Carey, I.M.; DeWilde, S.; Richards, N.; Cook, D.G., 2005: Trends in the prevalence and management of diagnosed type 2 diabetes 1994-2001 in England and Wales. Type 2 diabetes is an important cause of morbidity and mortality. Its prevalence appears to be increasing. Guidelines exist regarding its management. Recommendations regarding drug therapy have changed. Little is known about the influence of these...

Szymczakowski, W., 1976: Silphidae,Leiodidae, Catopidae and Colonidae (Coleoptera) of the Nahuel Huapi National Park in Argentina. Polskie pismo entomologiczne Bulletin entomologique de la Pologne: 0, 46 (3) 423-438

Park, S.Jae.; Lee, S.Yup.; Kim, T.Wan.; Jung, Y.Kyung.; Yang, T.Ho., 2012: Biosynthesis of lactate-containing polyesters by metabolically engineered bacteria. Due to increasing concerns about environmental problems, climate change and limited fossil resources, bio-based production of chemicals and polymers is gaining attention as one of the solutions to these problems. Polyhydroxyalkanoates (PHAs) are p...

Jordan, M.; Warchałowska-Sliwa, E.; Maryańska-Nadachowska, A., 1979: The effect of some selected pesticides on the embryonal development of Acheta domesticus. Effects of lindan, Karbatox [carbaryl], Gesagard and Miedzian [basic cupric chloride] on embryonal development of A. domesticus were investigated. Results show that Lindan and Karbatox are very toxic to the eggs and, depending on the applied conce...