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Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines


, : Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines. Journal of Biomedical Science 18: 21-21

Antigen-specific immunotherapy using DNA vaccines has emerged as an attractive approach for the control of tumors. Another novel cancer therapy involves the employment of the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA). In the current study, we aimed to test the combination of DMXAA treatment with human papillomavirus type 16 (HPV-16) E7 DNA vaccination to enhance the antitumor effects and E7-specific CD8+ T cell immune responses in treated mice. We determined that treatment with DMXAA generates significant therapeutic effects against TC-1 tumors but does not enhance the antigen-specific immune responses in tumor bearing mice. We then found that combination of DMXAA treatment with E7 DNA vaccination generates potent antitumor effects and E7-specific CD8+ T cell immune responses in the splenocytes of tumor bearing mice. Furthermore, the DMXAA-mediated enhancement or suppression of E7-specific CD8+ T cell immune responses generated by CRT/E7 DNA vaccination was found to be dependent on the time of administration of DMXAA and was also applicable to other antigen-specific vaccines. In addition, we determined that inducible nitric oxide synthase (iNOS) plays a role in the immune suppression caused by DMXAA administration before DNA vaccination. Our study has significant implications for future clinical translation.

US$19.90

PMID: 21385449

DOI: 10.1186/1423-0127-18-21


Other references

Kramer, K., J.M.; Jak, R., G.; Van-Hattum, B.; Hooftman, R., N.; Zwolsman, J., J.G., 2004: Copper toxicity in relation to surface water-dissolved organic matter: Biological effects to Daphnia magna. Water quality standards for copper are usually stated in total element concentrations. It is known, however, that a major part of the copper can be bound in complexes that are biologically not available. Natural organic matter, such as humic and f...

Peitersen, N., 1975: The use of straw for protein production. Ugeskrift for agronomer og hortonomer: 4, 4 (29 30) 558-561

Ashley R.P.; Albers John P., 1969: Elements associated with gold in the oxidized zone at Goldfield, Nevada. Special Paper - Geological Society of America Pages 480

Yoda, A.; Yoda, S., 1977: Association and dissociation rate constants of the complexes between various cardiac aglycones and sodium- and potassium-dependent adenosine triphosphatase formed in the presence of magnesium and phosphate. Molecular Pharmacology 13(2): 352-361

Pisciotto, P.T.; Gray, G.F.; Miller, D.R., 1978: Abdominal plasma cell pseudotumor. Journal of Pediatrics 93(4): 628-630

Bonner, M.D.; Harmon, L.G., 1956: The effect of various concentrations of sorbic acid in different pH levels on the viability of cottage cheese spoilage organisms. The growth of 20 strains of microorganisms, associated with cottage cheese spoilage, was studied in trypticase soya broth with various levels of pH and sorbic acid concentration. Two Acchromobacter spp. showed reduced viability with decreasing pH....

Attoh Kodjopa, 1984: Some constraints on the thermal causes of early Proterozoic metamorphic zones in northern Michigan. Program with Abstracts - Geological Association of Canada(Mineralogical Association of Canada(Canadian Geophysical Union, Joint Annual Meeting 9: 43

Van Harreveld, A., 1980: L-proline as a glutamate antagonist at a crustacean neuromuscular junction. The fast as well as the slow contractions of the adductor muscle in the claw of Procambarus clarkii are inhibited by L-proline. This inhibition is dose dependent and decreases with increasing frequency of stimulation of the "slow" fiber....

Katiyar, R.K.; Arunachalam, V., 1981: Single and three-way crosses for generating composite populations in rapeseed. Two systems of mating for generating composite populations were investigated using interline and intraline variability generated by disruptive and directional selection from self-compatible (SC) and self-incompatible (SI) populations of brown sars...

Pollo, L.A.E.; de Moraes, M.H.; Cisilotto, Júlia.; Creczynski-Pasa, Tânia.B.; Biavatti, M.W.; Steindel, M.; Sandjo, L.P., 2017: Synthesis and in vitro evaluation of Ca 2+ channel blockers 1,4-dihydropyridines analogues against Trypanosoma cruzi and Leishmania amazonensis: SAR analysis. Drugs containing the1,4-dihydropyridine (DHP) core have recently attracted attention concerning their antiparasitic effect against various species of Leishmania and Trypanosoma. This approach named drugs repositioning led to interesting results, w...