geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage


, : Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage. Fluids and Barriers of the Cns 11: 18-18

This article reviews current knowledge of the mechanisms underlying the initial hemorrhage and secondary blood-brain barrier (BBB) dysfunction in primary spontaneous intracerebral hemorrhage (ICH) in adults. Multiple etiologies are associated with ICH, for example, hypertension, Alzheimer's disease, vascular malformations and coagulopathies (genetic or drug-induced). After the initial bleed, there can be continued bleeding over the first 24 hours, so-called hematoma expansion, which is associated with adverse outcomes. A number of clinical trials are focused on trying to limit such expansion. Significant progress has been made on the causes of BBB dysfunction after ICH at the molecular and cell signaling level. Blood components (e.g. thrombin, hemoglobin, iron) and the inflammatory response to those components play a large role in ICH-induced BBB dysfunction. There are current clinical trials of minimally invasive hematoma removal and iron chelation which may limit such dysfunction. Understanding the mechanisms underlying the initial hemorrhage and secondary BBB dysfunction in ICH is vital for developing methods to prevent and treat this devastating form of stroke.

US$19.90

PMID: 25120903

DOI: 10.1186/2045-8118-11-18


Other references

Tankéré, F.; Bernat, I.; Vitte, E.; Lamas, G.; Bouche, P.; Fournier, E.; Soudant, J.; Willer, J.C., 2003: Hypoglossal-facial nerve anastomosis: dynamic insight into the cross-innervation phenomenon. The authors investigated the evolution of the dynamic features of the cross-innervation process in patients with complete facial palsy due to facial nerve transection during surgery for acoustic neuroma removal followed by a hypoglossal-facial ner...

Kanwar, R.; Dhillon, P.; Batta, S., 1978: Relative assessment of CO. J. 64 and CO. 1148 cane varieties for different agronomic and quality traits. Proceedings of the annual convention of the Sugar Technologists' Association of India: 2nd) Ag

Lereboullet J., 1968: The frequency of alcoholism at the hospital its cost abstract human nervous system disorders liver cirrhosis. Semaine Des Hopitaux De Paris: 1385

Petunnikov Gr, 1940: Glimmer- und Asbestvorkommen in der Gemeinde Vitolischte (Mazedonien). Mica and serpentine deposits in the Vitoliste region, Macedonia, Yugoslavia.

Wei, O.; Skidmore, A.K.; Toxopeus, A.G.; Hao, F., 2010: Long term vegetation landscape pattern with non-point source nutrient pollution in upper stream of Yellow River basin. Grassland, forest, and farmland are the dominant land covers in upper catchments of the Yellow River and their landscape status has direct connection with dynamics of non-point source (NPS) pollution. Understanding the correlations between landsca...

Leibee, G.L., 1985: Effects of storage at 1.1 celsius on the mortality of liriomyza trifolii diptera agromyzidae life stages in celery. Experiments were conducted to evaluate the effects of the recommended storage temperature for celery (1.1.degree. C) for various lengths of time on the mortality of the egg, larval, prepupal, and pupal stages of L. trifolii (Burgess). Mortality in...

Prokopenko, L.A.; Adamenko, A.M., 1989: Causes of errors in psychiatric expert testimony in adolescence. The sources of erroneous conclusions were analyzed in 393 cases of psychiatric investigation of males aged 19-22 years which had tested sane earlier (at ages 17 and 18 years). The errors were in only 10.3% of the cases related directly to difficul...

Naderi, S.; Matthies, C.; Samii, M., 2001: Trigeminal root recording in normal trigeminal function. Despite many investigations on the detection of trigeminal evoked potentials (TEP), there is still no consensus on a technique or interpretation of its components. In order to obtain clear TEP waveforms and analyze the origin of early components,...

Haraguchi, M.; Yamamoto, M.; Saito, A.; Kakeji, Y.; Orita, H.; Korenaga, D.; Sugimachi, K., 1994: Prognostic value of depth and pattern of stomach wall invasion in patients with an advanced gastric carcinoma. We reviewed data on 467 patients with advanced gastric carcinoma, taking into consideration tumor size, shape and depth of invasion, and growth pattern, either expanding or infiltrative. Three patterns of penetration were identified: i.e., funnel,...

Roese, N.J.; Pennington, G.L.; Coleman, J.; Janicki, M.; Li, N.P.; Kenrick, D.T., 2006: Sex differences in regret: all for love or some for lust?. Few sex differences in regret or counterfactual thinking are evident in past research. The authors discovered a sex difference in regret that is both domain-specific (i.e., unique to romantic relationships) and interpretable within a convergence o...