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Vascular invasion demonstrated by elastic stain-a common phenomenon in benign granular cell tumors


, : Vascular invasion demonstrated by elastic stain-a common phenomenon in benign granular cell tumors. Virchows Archiv 454(2): 211-215

Granular cell tumor is generally benign, but rare malignant cases have been documented. Features of malignancy include necrosis, cellular spindling, vesicular nuclei with large nucleoli, increased mitotic activity, high nuclear to cytoplasmic ratio, and pleomorphism, but not vascular invasion. Venous invasion was incidentally identified with the orcein elastic stain in an otherwise benign granular cell tumor (propositus case). Four further benign granular cell tumors were also analyzed; venous invasion was discovered in three. It is suggested that vascular invasion is not uncommon in granular cell tumors and should not lead to the classification of the tumor as malignant or atypical. It is likely that in most cases there is only invasion of the vascular wall. It is also suggested that some cases of vascular invasion identified by elastic stains in tumors such as colorectal carcinomas (where these stains are recommended for routine use) may also represent invasion of vascular structures without the propensity of metastasis.

US$19.90

PMID: 19066954

DOI: 10.1007/s00428-008-0702-x


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Fyhrquist, F.; Tikkanen, L.; Gronhagen-Riska, C.; Hortling, L.; Hichens, M., 1984: Inhibitor binding assay for angiotensin converting enzyme ec 3.4.15.1. A new principle for the determination of enzymes, applied to angiotensin-converting enzyme (ACE, EC 3.4.15.1) in human serum, is described. The enzyme inhibitor binding assay is based on specific binding of labeled inhibitor to the active center o...

Böthig, B.; Danes, L.; Dittmann, S., 1990: Immunogenicity of oral poliomyelitis vaccine (OPV) against variants of wild poliovirus type 3. Serological investigations of three groups of children from the German Democratic Republic (GDR) and from Czechoslovakia who had different immunization histories against poliomyelitis indicated that the immunity induced by oral poliovaccine (OPV)...

Jones, C.H.; Hiscock, I.V., 1927: The Preparation Of Annual Health Reports. American Journal of Public Health 17(11): 1152-1155

Smith I.E.; Milsom J.S., 1984: Late Cenozoic volcanism and extension in Eastern Papua. Geological Society Special Publications 16: 163-171

Steemers, F.J.; Meuris, H.G.; Verboom, W.; Reinhoudt, D.N.; van Der Tol, E.B.; Verhoeven, J.W., 1997: Water-Soluble Neutral Calix[4]arene-Lanthanide Complexes: Synthesis and Luminescence Properties. Water-soluble calix[4]arenes 10a,b with chromophores ("antenna") attached to the lower rim via a short spacer are described. In the neutral lanthanide complexes of 10a,b photoexcitation of the antenna induces lanthanide emission via intr...

Kostulas, V.; Eeg-Olofsson, O.; Olsson, T.; Link, H., 1986: Demonstration in children of oligoclonal IgG bands in unconcentrated CSF using agarose isoelectric focusing and immunolabeling. Agarose isoelectric focusing, followed by protein transfer to cellulose nitrate membrane and double-antibody avidin-biotin peroxidase staining (avidin-biotin agarose isoelectric focusing), was used to demonstrate oligoclonal IgG bands in unconcent...

Caldarelli, M.; D.R.cco, C.; L.M.rca, F., 1998: Treatment of hydromyelia in spina bifida. BACKGROUND: Cavitation of the spinal cord (hydrosyringomyelia) seems to be common in spina bifida patients, although the overall clinical and radiological incidence has very rarely been analyzed. The real incidence of the condition is, in fact, di...

Osborne, C.; Poizin, D.; Abdullahi, S., 1985: Medical dissolution and prevention of canine uroliths. Textbook of small animal surgery edited by Douglas H Slatter: -1826

Siplivaia, L.E.; Prokopenko, L.G., 1993: Ultraviolet irradiation-modified erythrocytes as immunomodulators in health and in Staphylococcus infection. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia: 34-38

Tacconi, R.; Santi, R., 1985: Reaction of some processing tomato lines to Meloidogyne incognita in the field. The reaction of 7 tomato lines and 4 cultivars selected for resistance to M. incognita was tested in an infested field at Bosco Mesola (Ferrara), Italy in a sandy soil, watered by soaking. The nematode infestation was absent or negligible in 84221...