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Venous thromboembolism risk prediction in ambulatory cancer patients: clinical significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio

, : Venous thromboembolism risk prediction in ambulatory cancer patients: clinical significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. International Journal of Cancer 136(5): 1234-1240

Neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios might represent a yet unrecognized risk factor for venous thromboembolism (VTE) in cancer out-patients receiving chemotherapy. Accordingly, this study was aimed at analyzing the significance of these novel markers in the risk prediction of a first VTE episode in a population representative of a general practice cohort. To this purpose, a mono-institutional cohort study was conducted to retrospectively analyze NLR and PLR in 810 consecutive cancer out-patients with primary or relapsing solid cancer at the start of a new chemotherapy regimen. Over a median follow-up of 9.2 months, VTE occurred in 6.7% of patients. Incidental VTE was diagnosed at time of restaging in 47% of cases. Median pre-chemotherapy NLR (p = 0.015) and PLR (p = 0.040) were significantly higher in patients with intermediate risk class who developed symptomatic VTE with a twofold increased VTE risk for both inflammation-based markers (NLR: p = 0.022; PLR: p = 0.037) and a worst 1-year VTE-free survival for patients with high NLR or PLR. However, only PLR (HR = 2.4, p = 0.027) confirmed to be an independent predictor of future VTE in patients in the intermediate risk class in multivariate analysis, together with ECOG performance status (HR = 3.4, p = 0.0002) and bevacizumab use (HR = 4.7, p = 0.012). We may, thus, conclude that PLR, but to a lesser extent NLR, could represent useful clinical predictors of VTE, especially in selected categories of patients such as those in the intermediate risk class in whom the assessment of PLR could allow a better risk stratification of VTE without additional costs to the national health systems.


PMID: 25042739

DOI: 10.1002/ijc.29076

Other references

Callegari, G., 1954: New orientations on therapy of hepatoses in pregnancy. Rivista D'ostetricia E Ginecologia Pratica 36(2): 75-82

Greenberg, B., 1977: Motherdear...a tribute of love. Journal of Gerontological Nursing 3(3): 13-15

Lee, J.B.n; Lee,, 1992: PCR amplification of DNA extracted from formalin-fixed tissue. In this study we try to confirm whether the DNA from formalin-fixed tissue be suitable for forensic application such as individual identification or examination of medicolegal evidences using PCR. Fresh placenta were taken from 18 different women...

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Ashburner, LD.; Ehi, AS., 1973: Chilodonela cyprini (Moroff), a parasite of freshwater fish and its treatment. Bulletin Aust Soc Limnol, 5: 3-4

Fanciullacci, F.; Colpi, G.M.; Beretta, G.; Zanollo, A., 1988: Cortical evoked potentials in subjects with true premature ejaculation. Cortical somato-sensory evoked potentials (SEPs) from pudendal stimulation were determined in 23 patients with true premature ejaculation (TPE) and in 25 subjects as a control group. SEPs give a cortical representation of the sensory stimuli arisi...

Mackinnon, I.H.; Michael, S.T.; Polatin, P., 1954: Isonicotinic acid hydrazide in the treatment of schizophrenia. Psychiatric Quarterly 28(4): 668-672

Steiner, K.C., 1998: A decline-model interpretation of genetic and habitat structure in oak populations and its implications for silviculture. Oak decline is attributable to predisposing conditions of both biotic and abiotic origin, and to numerous insects, pathogens, and abiotic events that act as intermediate or ultimate agents of mortality. The precise causal factors vary with circums...

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