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Vitamin D deficiency in children with a chronic illness-seasonal and age-related variations in serum 25-hydroxy Vitamin D concentrations

, : Vitamin D deficiency in children with a chronic illness-seasonal and age-related variations in serum 25-hydroxy Vitamin D concentrations. Plos One 8(4): E60856-E60856

Children and adolescents with a chronic illness have potential risk factors for vitamin D deficiency. An optimal vitamin D status might have multiple health effects. This study evaluated vitamin D status and its association with age, gender, and season in a large cohort of chronically ill Finnish patients at a tertiary pediatric outpatient clinic. A cross-sectional register-based study was carried out, involving altogether 1351 children (51% boys, age range 0.2-18 years), who visited the outpatient clinic during 2007-2010 and had their vitamin D status (S-25-OHD) determined. A post-doc analysis was conducted to identify predisposing and preventing factors for vitamin D deficiency. Almost half (47%) of the S-25-OHD values were consistent with subnormal vitamin D status (S-25-OHD <50 nmol/L) while only 12% were >80 nmol/L. Age and season were the most important determinants for S-25-OHD concentration. Mean S-25-OHD concentration differed between age groups (Kruskal-Wallis; p<0.001), adolescents being at highest risk for vitamin D insufficiency. Young age and vitamin D supplementation were preventive factors for deficiency, while non-Finnish ethnic background was a predisposing factor. S-25-OHD showed significant seasonal variation in children older than 6 years. In the whole cohort, S-25-OHD was on average 13 nmol/L higher in summer than in winter, and the prevalence of vitamin D deficiency ( =  S-25-OHD <37.5 nmol/l) varied from 11% in summer to 29% in winter. The finding that almost half of the studied Finnish children with a chronic illness had suboptimal vitamin D status is alarming. Inferior vitamin D status was noted in adolescents compared with younger children, suggesting that imbalance between intake and requirement evolves with age. Although less common during summer, subnormal vitamin D status was still observed in 28% of those evaluated in summer. Clinicians should identify individuals at risk and actively recommend vitamin D supplementation.


PMID: 23585857

DOI: 10.1371/journal.pone.0060856

Other references

Holme, P., 2002: Edge overload breakdown in evolving networks. We investigate growing networks based on Barabási and Albert's algorithm for generating scale-free networks, but with edges sensitive to overload breakdown. The load is defined through edge betweenness centrality. We focus on the situation w...

Thothathiri G., 1998: Geodata Division; an overview. Records of the Geological Survey of India 129, Part 2: 144

Heegaard, E.; Birks, H.J.B.; Telford, R., J., 2005: Relationships between calibrated ages and depth in stratigraphical sequences: an estimation procedure by mixed-effect regression. We present a procedure for estimating age-depth relationships in stratigraphical sequences by means of it generalized mixed-effect regression using an ancillary function for the partitioning of the fixed effect and the random effect corresponding...

Anonymous, 1980: Comparing dental care systems in California. Employee Benefit Plan Review 34(8): 34-35

Keys J.E.; Smith L.W., 1978: Effect of corn silage diets supplemented with corn stover and 2 levels of nitrogen from poultry excreta on dry matter intake and growth of yearling holstein heifers. Journal of Dairy Science 61(SUPPL 1): 199-200

Balaban, V.G.; Voĭtenko, V.P., 1965: Allergic Wissler-Fanconi subsepsis. Voprosy Okhrany Materinstva i Detstva 10(11): 52-56

Lamprecht, A.; Yamamoto, H.; Ubrich, N.; Takeuchi, H.; Maincent, P.; Kawashima, Y., 2005: FK506 microparticles mitigate experimental colitis with minor renal calcineurin suppression. Purpose. FK506 microparticles providing selective colonic drug delivery were tested for their efficiency in a local treatment to the inflamed gut tissue in inflammatory bowel disease (11313). Because FK506 proved its distinct mitigating potential...

Okui, S.; Suzuki, Y.; Momose, K., 1963: Relationship Between Succinate Oxidase And Succinate: (Acceptor) Oxidoreductase. Journal of Biochemistry 54: 471-476

Stein, P.D., 2000: Scintigraphy-ventilation/perfusion scanning and imaging of the embolus. Purpose: This is a review of data on ventilation/perfusion (V/Q) imaging obtained in the collaborative study, Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). Special emphasis is given to data obtained subsequent to the main PIO...

Vazquez J.A.; Paul H.S.; Adibi S.A., 1986: Relationship between plasma and tissue parameters of leucine metabolism. Federation Proceedings 45(4): 1028