geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

WITHDRAWN: Terazosin for benign prostatic hyperplasia


, : WITHDRAWN: Terazosin for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews (): Cd003851-Cd003851

Lower urinary tract symptoms associated with benign prostatic obstruction (BPO) occur in up to 70% of men over the age of 60 years. To relieve these bothersome symptoms, treatment options include alpha-antagonists, also know as alpha-blockers. We conducted a systematic review to evaluate the effectiveness and adverse effects of the alpha-blocker, terazosin, for treatment of urinary symptoms associated with BPO. Trials were searched in computerized general and specialized databases (MEDLINE, Cochrane Library), by checking bibliographies, and by contacting manufacturers and researchers. Studies were included if they (1) were randomized trials of at least 1 month duration, and (2) included men with symptomatic BPO and compared terazosin with placebo or active controls. Study, patient characteristics and outcomes data were extracted in duplicate onto standardized forms utilizing a prospectively developed protocol. The main outcome measure for comparing the effectiveness of terazosin with placebo or other BPO medications was change in urological symptoms as measured by validated symptom scores. Secondary outcomes included urodynamic measures. The main outcome measure for adverse effects was the number of men reporting side effects. We also evaluated the number of men withdrawing from treatment and the number withdrawing due to adverse effects. Seventeen studies involving 5151 subjects met inclusion criteria (placebo-controlled (n = 10); alpha-blockers (n = 7); finasteride alone or in combination with terazosin as well as placebo (1); microwave therapy (TUMT) (1). Study duration ranged from 4 to 52 weeks. Mean age was 65 years and 82% of men were white. Baseline urologic symptom scale scores and flow rates demonstrated that men had moderate BPO. Efficacy outcomes were rarely reported in a fashion that allowed for data pooling but indicated that terazosin improved symptom scores and flow rates more than placebo or finasteride and similarly to other alpha antagonists. The pooled mean percentage improvements for the Boyarsky symptom score was 37% for terazosin versus 15% for placebo (n = 4 studies). The mean percentage improvement for the American Urological Association symptom score (AUA) was 38% compared to 17% and 20% for placebo and finasteride, respectively (n = 2 studies). The pooled mean improvement in the International Prostate Symptom Score (IPSS) (40%) was similar to tamsulosin (43%). Peak urine flow rates improved greater with terazosin (22%), than placebo (11%) and finasteride (15%) but did not differ significantly from the other alpha-blockers. The percentage of men discontinuing terazosin was comparable to men receiving placebo and finasteride but was greater then with other alpha-antagonists. Adverse effects were greater than placebo and included dizziness, asthenia, headache, and postural hypotension. The available evidence suggests that terazosin improves urinary symptoms and flow measures associated with BPO. Effectiveness is superior to placebo or finasteride, similar to other alpha-blockers but less than TUMT. Adverse effects were generally mild but more frequent than other alpha-blockers and associated with between a two-to-four fold increase in treatment discontinuation.

US$19.90

PMID: 21901686

DOI: 10.1002/14651858.CD003851.pub2


Other references

Roman, J.; Rodriguez Marcano, A., 1985: Effect of the fungus Paecilomyces lilacinus on the larval populations and root knot formation of Meloidogyne incognita in tomato. Two experiments were conducted in the greenhouse to determine the effect of P. lilacinus in controlling the larvae and root knot or root gall formation of M. incognita in tomato cultivar Floradel. The plants were inoculated with the fungus alone,...

Oguchi, Y.; Morita, I.; Fujii, T.; Matsunaga, K.; Yoshikumi, C.; Kawai, Y.; Tsuru, S.; Nomoto, K., 1987: Involution of the thymus in tumor-bearing mice and its restoration by PSK. II. Mechanism of the involution and its restoration. In C3H/He mice, the weight and cell number of the thymus were reduced and the size distribution (scatter profile measured by flow cytometer) of the thymus cells was changed 1 week after subcutaneous inoculation of X5563 plasmacytoma. This involuti...

Hu, J-Jie.; Liao, J-Ying.; Meng, Y.; Guo, Y-Mei.; Chen, X-Wen.; Zuo, Y-Xian., 2011: Identification of Sarcocystis cymruensis in wild Rattus flavipectus and Rattus norvegicus from Peoples Republic of China and its transmission to rats and cats. Sarcocystis cymruensis was initially identified in skeletal muscles of 22 (11.6%) of 189 wild rats (Rattus spp.) captured in 2008 in Anning and Kunming, Peoples Republic of China. Sarcocyst walls were thin (<1 mu m) and smooth. Ultrastructurall...

Rock, G., 2014: South African lymphoma study group. Transfusion and Apheresis Science 49(1): 1-1

Blandy, J.P.; England, H.R.; Evans, S.J.; Hope-Stone, H.F.; Mair, G.M.; Mantell, B.S.; Oliver, R.T.; Paris, A.M.; Risdon, R.A., 1980: T3 bladder cancer--the case for salvage cystectomy. Seven hundred and four patients with bladder cancer treated by radiotherapy at the London Hospital between 1965 and 1974 have been followed for a minimum period of 5 years. Invasive tumours were usually treated by radical radiotherapy. Cystectomy...

Savage, A., 1996: Private practice. Same standards of staffing and equipment should apply in NHS and private sector. Bmj 313(7069): 1401-1401

Cadova, M.; Vilimek, M.; Daniel, M., 2015: A comparative study of muscle force estimates using Huxley's and Hill's muscle model. Determination of muscle forces in individual muscles is often essential to assess optimal performance of human motion. Inverse dynamic methods based on the kinematics of the given motion and on the use of optimisation approach are the most widely...

Dioscoridi, L.; Bisogni, D.; Freschi, G., 2015: Hepatocellular carcinoma with osteoclast-like giant cells: report of the seventh case in the literature. Hepatocellular carcinoma with osteoclast-like giant cells is extremely rare, and only six cases have been previously reported. Its histogenesis is at the moment controversial. The authors report a case of hepatocellular carcinoma with osteoclast-l...

Bozovic-Spasojevic, I.; Azim, H.A.; Paesmans, M.; Suter, T.; Piccart, M.J.; de Azambuja, E., 2011: Neoadjuvant anthracycline and trastuzumab for breast cancer: is concurrent treatment safe?. Lancet. Oncology 12(3): 209-211

Zhelyazkov; Spatschek, 1988: Nonlinear surface waves on a plasma layer. Physical Review. A, General Physics 38(12): 6304-6315