+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Whipple disease

, : Whipple disease. Current Opinion in Gastroenterology 24(2): 141-148

The availability of and advantages in molecular technology and immunology have led to an improved understanding of the etiology and pathogenesis of Whipple disease. As this rare infection represents a model disease reflecting the input of novel findings into clinical medicine and therapy, this review intends to highlight newer findings and put them in context. Sequencing of 16S rRNA allowed the phylogeny of the bacterium to be determined. The culture and subsequent genome analysis have led to improved diagnosis and monitoring of the disease, for example by PCR or immunohistochemistry. New experimental approaches hint of defects in T-cell and macrophage immunity in patients. Antibiotic therapy will soon be based on data from the first prospective therapy study. Within a few years the findings from molecular genetics and immunology as well as concerted research activities from the European Consortium on Whipple Disease which established a data and material bank could be translated into clinical medicine. Thus, for patients with Whipple disease an improved basis for diagnosis and therapy have been achieved.


PMID: 18301263

DOI: 10.1097/MOG.0b013e3282f3f4f1

Other references

Reymond, M.A.; Buser, P.; Stulz, P., 1991: Traumatic ruptures of the thoracic aorta. The authors present a group of 22 patients admitted for traumatic rupture of the thoracic aorta between 1969 and 1989. Most of them were polytraumatized patients (mean ISS 45). The majority of the injured patients possibly died before arriving at...

Chatterjee, R.; Tarwater, P.; Neogi, D.; Ghosh, A.; Roy, P.; Sengupta, S.; Gupta, P., 2004: Estimation of HIV seroprevalence in blood bank camps in Kolkata, India. Transfusion Medicine 14(1): 77-78

Kim WolSoo; Chung SoonJu; Kim KilYong; DeJong, T., 2003: The use of nitrate color paper to test nitrate status of 'Kyoho' grapevines in Korea. The absorption of high amounts of nitrogen from the soil and rapid translocation of N to shoots and berries in 'Kyoho' grapevines (Vitis labruscana) can result in vigorous growth and potentially in reduced floral bud differentiation as w...

Bleu, J.; Herfindal, I.; Loison, A.; Kwak, A.M.G.; Garel, M.; Toïgo, C.; Rempfler, T.; Filli, F.; Sæther, B-Erik., 2016: Age-specific survival and annual variation in survival of female chamois differ between populations. In many species, population dynamics are shaped by age-structured demographic parameters, such as survival, which can cause age-specific sensitivity to environmental conditions. Accordingly, we can expect populations with different age-specific su...

Marci, F.; Goracci, G.; Negri, P.L., 1982: Fluoride content of enamel in an area where the water is richly fluoridated. Rivista Italiana di Stomatologia 51(10): 867-870

Halbhuber, K.J., 1980: Conformation preserving methods of fixation. For immune- and enzymehistochemical studies it is necessary to preserve biological activities of fixed cells and tissues. Aldehyde fixed biological materials give not in all cases results to provide for the needs in histochemistry, because aldehyd...

Herz, K.G., 1971: Community resources and services to help independent living. Gerontologist 11(1): 59-66

Lukasz, A.; Hellpap, J.; Horn, Rüdiger.; Kielstein, J.T.; David, S.; Haller, H.; Kümpers, P., 2008: Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays. In critically ill patients, the massive release of angiopoietin-2 (Ang-2) from endothelial Weibel-Palade bodies interferes with constitutive angiopoietin-1 (Ang-1)/Tie2 signaling in endothelial cells, thus leading to vascular barrier breakdown fol...

Vishnevskiĭ, A.A.; Romashov, F.N., 1969: Notes on the 2d International Symposium on Heart Transplantation. Eksperimental'naia Khirurgiia i Anesteziologiia 14(5): 89-92

Guse, A.H.; Tsygankov AYu; Bröker, B.M.; Roth, E.; Emmrich, F., 1993: Signal transduction in T lymphocytes and monocytes: effects of the anti-CD4 antibody MAX.16H5. Year in Immunology 7: 175-181