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Why post-progression survival and post-relapse survival are not appropriate measures of efficacy in cancer randomized clinical trials


, : Why post-progression survival and post-relapse survival are not appropriate measures of efficacy in cancer randomized clinical trials. International Journal of Cancer 136(10): 2444-2447

Comparisons of post-relapse survival (PRS) and post-progression survival have been used to measure efficacy in some cancer clinical trials. These comparisons are an attempt to account for second-line therapies and to identify benefits that do not translate in longer overall survival. However, the use of PRS comparisons can be misleading (either a longer or shorter PRS may indicate a benefit, depending on the circumstances) and can result in biased estimates (because of selection). Here, we describe the problems surrounding PRS comparisons and propose alternative approaches to deal with non-randomized therapies administered after progression to the experimental treatment.

US$19.90

PMID: 25333417

DOI: 10.1002/ijc.29278


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Beer, J.S.; Knight, R.T.; D'Esposito, M., 2006: Controlling the integration of emotion and cognition: the role of frontal cortex in distinguishing helpful from hurtful emotional information. Emotion has been both lauded and vilified for its role in decision making. How are people able to ensure that helpful emotions guide decision making and irrelevant emotions are kept out of decision making? The orbitofrontal cortex has been identif...

Perez, M.G.V.; Vassilev, T.; Kemmerly, S.A., 2002: Rhodococcus equi infection in transplant recipients: a case of mistaken identity and review of the literature. The incidence of Rhodococcus equi infection in solid-organ transplant recipients continues to rise throughout the world. Unfortunately, this opportunistic pathogen is still underestimated and potentially disregarded by physicians and microbiology...

Sapuppo A., 1974: Lymphocytic reactivity in vitro considerations pertaining to dermatology. Fracastoro 67(1-2): 37-54

Glick, A.D.; Page, D.L., 1992: Primitive neuroepithelial tumors with vermiform processes (filiform neuroepithelial tumors). Immunocytochemical and ultrastructural study of 2 cases. Two unique, poorly-differentiated neuroepithelial tumors are described, one in a 35-year-old woman with an anterior mediastinal tumor and one in a 71-year-old woman with a left femoral mass. Immunocytochemical stains demonstrated Neuron specific e...

Mhadhbi, H.; Bouzouita, N.; Martel, A.; Zarrouk, Hédi., 2007: Occurrence of mycotoxin patulin in apple-based products marketed in Tunisia. An investigation on the presence of mycotoxin patulin was performed on 71 apple juices and concentrates and 21 infant fruit purees purchased from retail outlets or producers in Tunisia, by reversed-phase high-performance liquid chromatography usin...

Kapitanova, O.N.; Prokofev, B.Lgovs, A., 1963: Cytological Characteristics Of The Development Of 3 Strains Of Act. Streptomycini Kras. On Various Media. Antibiotiki 8: 1074-1080

Mariano, J., 1951: Administrative data from the leprosaria of Minas Gerais in 1949. Arquivos Mineiros de Leprologia 11(2): 84-93

Littlewood, Keith, 1998: Anesthetic considerations for hepatic cryotherapy. The evolution of hepatic cryotherapy as an accepted treatment for patients with non-resectable hepatic malignancy has required concurrent evaluation and development of perioperative anesthetic management of these cases. Review of published and ins...

Coyle, Elizabeth E., 1930: The algal food of Pimephales promelas, the fathead minnow. Notes are given on feeding habits, methods of collection and study, and stomach contents of 203 individuals of P. promelas studied from different localities and types of environment. There are tables of the species of algae and of the distribution...

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