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Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation

, : Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation. Mayo Clinic Proceedings 87(8): 760-765

Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.


PMID: 22809886

DOI: 10.1016/j.mayocp.2012.05.006

Other references

Thimmappaya B.; Weinberger C.; Schneider R.J.; Shenk T., 1982: Adenovirus vai rna is required for efficient translation of viral messenger rna at late times after infection. Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNA). Each mutant fails to synthesize 1 of the 2 VA RNA species. The variant that does not produce the minor VAII species...

Gao ZhiKui; Gao RongFu; H.J.nPing; Wang Mei, 2005: Effects of environmental factors on unsteady-state photosynthesis in greenhouse aubergine. Transient photosynthesis was measured by CIRAS-2 automatic recording at an interval of 2 seconds, and an unsteady-state photosynthesis was observed in greenhouse-grown aubergine. The results of the transient measurement of photosynthetically activ...

Scott, D.; Park, M.S.; Kim, T.N.; Ryu, J.Y.; Hong, H.C.; Yoo, H.J.; Baik, S.H.; Jones, G.; Choi, K.M., 2016: Associations of Low Muscle Mass and the Metabolic Syndrome in Caucasian and Asian Middle-aged and Older Adults. Age-related declines in skeletal muscle mass may confer significant metabolic consequences for older adults. Associations of low muscle mass and metabolic syndrome (MetS) in Caucasians, and comparisons with associations observed in Asian populatio...

Kelley, J.D.; Ulrich, A., 1966: Distribution of nitrate nitrogen in the blades and petioles of sugar beets grown at deficient and sufficient levels of nitrogen. Sugar beets were grown for 96 days in nutrient solutions containing deficient and non-deficient amounts of N. Nitrate concentrations of blades and petioles increased from low values in the younger. leaves to increasingly higher values in older lea...

Peyraud, C.; Bastien, C., 1961: An electronic light chopper used for study of luminous stimulation. Diagram for instrument is presented.

Schultz, D.R.; Becker, E.L., 1967: The alteration of endotoxin by postheparin plasma and its purified fractions. I. Comparison of the ability of guinea pig postheparin and normal plasma to detoxify endotoxin. Journal of Immunology 98(3): 473-481

Camarda; Phillips; White, 1986: Neutron total cross section of 40Ca and cross section difference of 44Ca-40Ca. Physical Review. C, Nuclear Physics 34(3): 810-814

Mayo, K.; Vana, M.L.; McDermott, J.; Huseby, D.; Leis, J.; Barklis, E., 2002: Analysis of Rous sarcoma virus capsid protein variants assembled on lipid monolayers. During assembly and morphogenesis of Rous sarcoma virus (RSV), proteolytic processing of the structural precursor (Pr76Gag) protein generates three capsid (CA) protein variants, CA476, CA479, and CA488. The proteins share identical N-terminal doma...

Ficheux H.; Levillain P.; Francoual J.; Leluc R.; Lemonnier A., 1989: Simultaneous determination of hemoglobin and coproporphyrin by second derivative differential spectrophotometry application to the diagnosis of meconium aspiration. We describe a simple, fast method for simultaneous measurement of hemoglobin and coproporphyrin in urine and amniotic fluid, by second-derivative differential spectrophotometry. Both pigments were determined in biological samples without prior ext...

Ingelsoll Raymond V.; Graham Stephan A., 1981: Recognition of shelf-slope break along tectonically active, ancient continental margins. AAPG Bulletin 65(5): 939