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1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity

, : 1,2,4-triazole derivatives as potential scaffold for anticonvulsant activity. Central Nervous System Agents in Medicinal Chemistry 15(1): 17-22

The search for new anticonvulsant agent with more selectivity and lower toxicity continues to be an area of rigorous investigation in medicinal chemistry. Epilepsy is a chronic disorder of brain whose treatment consists of controlling seizures with antiepileptic drugs that very often related with side-effects which in rare circumstances can be potentially life-threatening. Triazolam and Alprazolam are established drugs used in epilepsy which have triazole moiety. The potency and broad spectrum of the pharmacological response of triazole moiety as anticonvulsant agent have attracted the attention of medicinal chemists to explore this framework for its potential. The literature shows that different substitution on triazole ring exhibit potent antiepileptic activity with no or lesser neurotoxicity. The present review is a sincere attempt to compile the reported potent triazole derivatives with significant anticonvulsant action.


PMID: 25675400

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Rosi, G.; Gambarini, G.; Colli, V.; Gay, S.; Scolari, L.; Fiorani, O.; Perrone, A.; Nava, E.; Fasolo, F.; Visca, L.; Zanini, A., 2004: Characterisation of the TAPIRO BNCT thermal facility. Dosimetry and spectrometry measurements have been carried out in the thermal column of the research fast reactor RSV-TAPIRO (ENEA-Casaccia, Rome) in order to investigate its suitability for irradiation of cells or mice, with a view to research in...

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Harrington, W., Z.; Strohschein, B., L.; Reedy, D.; Harrington, J., E.; Schiller, W., R., 1995: Pavement temperature and burns: Streets of fire. Study objective: To measure pavement temperatures over a 24-hour period to determine when patients are at risk for burns and to report cases of pavement burns with predisposing factors. Design: Descriptive study of pavement temperatures and retros...