+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study

, : 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study. Atherosclerosis 241(1): 12-17

In observational studies, low 25-hydroxyvitamin D (25(OH)D) has been associated with increased risk of coronary heart disease (CHD), and this association may vary by race. Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) might account for similar bioavailable vitamin D in blacks despite lower mean 25(OH)D. We hypothesized that the associations of low 25(OH)D with CHD risk would be stronger among whites and among persons with genotypes associated with higher DBP levels. We measured 25(OH)D by mass spectroscopy in 11,945 participants in the ARIC Study (baseline 1990-1992, mean age 57 years, 59% women, 24% black). Two DBP SNPs (rs7041; rs4588) were genotyped. We used adjusted Cox proportional hazards models to examine the association of 25(OH)D with adjudicated CHD events through December 2011. Over a median of 20 years, there were 1230 incident CHD events. Whites in the lowest quintile of 25(OH)D (<17 ng/ml) compared to the upper 4 quintiles had an increased risk of incident CHD (HR 1.28, 95% CI 1.05-1.56), but blacks did not (1.03, 0.82-1.28), after adjustment for demographics and behavioral/socioeconomic factors (p-interaction with race = 0.22). Results among whites were no longer significant after further adjustment for potential mediators of this association (i.e. diabetes, hypertension). There was no statistically significant interaction of 25(OH)D with the DBP SNPs rs4588 (p = 0.92) or rs7041 (p = 0.87) in relation to CHD risk. Low 25(OH)D was associated with incident CHD in whites, but no interactions of 25(OH)D with key DBP genotypes was found.


PMID: 25941991

DOI: 10.1016/j.atherosclerosis.2015.04.803

Other references

Taft, R., 1969: Peak experiences and ego permissiveness. An exploratory factor study of their dimensions in normal persons. Acta Psychologica 29(1): 35-64

Vazquez F.; Artega R.; Schermerhorn J., 1980: Mineral deposits in southeastern Iberian Peninsula. Boletin Geologico y Minero: , Pages 293-342. 1980.

Thomson, R.G.; Ruhnke, H.L., 1963: Haemophilus Septicemia in Piglets. A fatal disease of piglets is described from which an Haemophilus organ-ism was isolated. The disease was characterized by bacteremia with embolism and thrombosis of capillaries especially in the spleen, lymph nodes, lung and liver.

D.A.uja, A.S.; Lopez C.Alfredo; Chavira S.Horacio; Oseguera M.David, 2000: Frequent pathological conditions in working equids in Mexico. Donkeys, mules and horses are used for fieldwork to carry loads, pull carts and for other tasks in many poor communities of Mexico helping marginated peasants. Most of these animals are overworked, undernourished and in bad general condition. The...

Schooley, J.C.; Hayes, J.M.; Cantor, L.N.; Havens, V.W., 1967: Studies on the behavior of erythropoietin-sensitive cells in the mouse during recovery from 200 roentgens of whole-body irra- diation. Ten days alter 200 R of 60co whole-body irradiation the hematopoietic system of the polycythemic mouse contains 3 to 4 times as many cells available during a 6-hr.period for stimulation by erythropoietin into erythroid cells as does the unirradiat...

Bouhour, J.B.; Mainard, R.; Nicolas, G.; Godin, J.F.; Cadudal, J.L.; Horeau, J., 1973: Apparently primary pericardial effusion in the newborn infant. Archives des Maladies du Coeur et des Vaisseaux 66(7): 909-914

Teiling, E.; Westling, R., 1965: Richard Westling, discoverer of the penicillium and its miraculous action. Svensk Farmaceutisk Tidskrift 69(29): 831-836

Hirasawa Naohiko; Hara Keiichiro, 2007: Report of the activity at the S17 base near Syowa Station, Antarctica, related to the ANTSYO-II project in 2006-2007 summer season. This report summarizes activity at the S17 base on the Antarctic ice sheet near Syowa Station in 2006-2007 summer. The description focuses on the period from the opening to closing of the S17 base. The appendix lists daily activity in detail. The...

Lan, N.; Baker, L., 2007: Biomechanical couplings between elbow and forearm movements. Control of reaching task requires a strategy that takes into account biomechanical couplings in the musculoskeletal system. In a kinematic study, normal subjects were asked to reach to, grasp a cup, and bring it back. It was found that forearm rot...

Orsi, K.Cristina.Sbampato.Calado.; Avena, M.José.; Lurdes de Cacia Pradella-Hallinan, M.; da Luz Gonçalves Pedreira, M.; Tsunemi, M.Harumi.; Machado Avelar, A.Ferreira.; Pinheiro, E.Moreira., 2017: Effects of Handling and Environment on Preterm Newborns Sleeping in Incubators. To describe the total sleep time, stages of sleep, and wakefulness of preterm newborns and correlate them to levels of sound pressure, light, temperature, relative air humidity, and handling inside incubators. Observational, correlational study. A...