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A Neutral Effect of Metformin Treatment on Macroprolactin Content in Women with Macroprolactinemia


, : A Neutral Effect of Metformin Treatment on Macroprolactin Content in Women with Macroprolactinemia. Experimental and Clinical Endocrinology & Diabetes

NlmCategory="UNASSIGNED">Background: Metformin decreases serum levels of monomeric prolactin. No previous study has investigated the effect of metformin on macroprolactin content in patients with macroprolactinemia. Methods: We studied three age-, sex- and weight-matched groups of patients: 15 women with monomeric prolactin, 12 women with macroprolactin, as well as 15 women with normal prolactin levels. Because of coexisting 2 diabetes or prediabetes all patients were treated with metformin (1.7-3 g daily). Plasma lipids, glucose homeostasis markers, as well as serum levels of prolactin and macroprolactin were assessed at baseline and after 4 months of metformin treatment. Results: As expected, metformin reduced plasma glucose and triglycerides, as well as improved insulin sensitivity in all treatment groups. Moreover, the drug reduced post-polyethylene glycol prolactin levels and tended to reduce pre-polyethylene glycol prolactin levels in women with monomeric prolactin but not in women with macroprolactinemia and women with normal prolactin levels. Conclusion: The obtained results indicate that metformin has a negligible effect on macroprolactin levels.

US$19.90

PMID: 27750350

DOI: 10.1055/s-0042-117718


Other references

Thompson, A.H.; Borden, K.; Belton, K.L., 2004: Intentional and unintentional injuries across health regions in Alberta, Canada: an implication for policy. The growing practice of including intentional injuries (suicide and interpersonal violence) under the injury control umbrella has produced some controversy. The present study was designed to determine whether or not there might be an empirical bas...

Laroche, M.; Gilles, H.; Girard, S., 2011: High-peak-power nanosecond pulse generation by stimulated Brillouin scattering pulse compression in a seeded Yb-doped fiber amplifier. We demonstrate the generation of nanosecond and multikilowatt peak-power pulses in a double-clad Yb-doped fiber amplifier seeded by a spectrally narrowed gain-switched laser diode. Injected pulses with 100 ns duration were simultaneously compresse...

Larsen, H.S.; Russell, R.G.; Rouse, B.T., 1983: Recovery from lethal herpes simplex virus type 1 infection is mediated by cytotoxic T lymphocytes. The ability of herpes simplex virus (HSV)-specific, cytotoxic T lymphocytes to mediate recovery of mice lethally infected with HSV was examined. Adoptive transfer of splenocytes from mice that had been primed in vivo with HSV and restimulated with...

Simon, J.L., 1975: The positive effect of population growth on agricultural saving in irrigation systems. Given that agricultural output represents perhaps half of a poor LDC's total product, and given that (contrary to the common opinion) the rate of investment in LDC agriculture is quite respectable compared to the industrial sector, if populat...

Smith, J.A.; Khan, M.; Magnani, D.D.; Harms, J.S.; Durward, M.; Radhakrishnan, G.K.; Liu, Y-Ping.; Splitter, G.A., 2014: Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. Brucella melitensis is a facultative intracellular bacterium that causes brucellosis, the most prevalent zoonosis worldwide. The Brucella intracellular replicative niche in macrophages and dendritic cells thwarts immune surveillance and complicate...

Foster, R.; Richter, P., 2008: The role of hospitals in pandemic influenza planning, response and recovery. Journal of the South Carolina Medical Association 104(5): 146-148

Kurbatskii, Np, 1976: On the mechanism of occurrence of forest fires due to lighting. Lesovedenie 3 95-98

Khan, H.Aziz.; Siddique, K.H.M.; Munir, R.; Colmer, T.David., 2016: Salt sensitivity in chickpea: Growth, photosynthesis, seed yield components and tissue ion regulation in contrasting genotypes. Chickpea is a relatively salt sensitive species but shows genotypic variation for salt tolerance, measured as grain yield per plant in mild-to-moderately saline soil. This experiment was designed to evaluate some physiological responses to salinit...

Hocker, H., 1953: Concordant occurrence of exudative eczematoid in uniovular female twins. Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und Verwandte Gebiete 4(1): 21-24

Verma, S., 2008: Rebuttal: Toil and trouble?: Should residents be allowed to moonlight?: YES. Canadian Family Physician Medecin de Famille Canadien 54(11): 1521-1522