+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A Population-Based Gaussian Mixture Model Incorporating 18F-FDG PET and Diffusion-Weighted MRI Quantifies Tumor Tissue Classes

, : A Population-Based Gaussian Mixture Model Incorporating 18F-FDG PET and Diffusion-Weighted MRI Quantifies Tumor Tissue Classes. Journal of Nuclear Medicine 57(3): 473-479

The aim of our study was to create a novel Gaussian mixture modeling (GMM) pipeline to model the complementary information derived from(18)F-FDG PET and diffusion-weighted MRI (DW-MRI) to separate the tumor microenvironment into relevant tissue compartments and follow the development of these compartments longitudinally. Serial (18)F-FDG PET and apparent diffusion coefficient (ADC) maps derived from DW-MR images of NCI-H460 xenograft tumors were coregistered, and a population-based GMM was implemented on the complementary imaging data. The tumor microenvironment was segmented into 3 distinct regions and correlated with histology. ANCOVA was applied to gauge how well the total tumor volume was a predictor for the ADC and (18)F-FDG, or if ADC was a good predictor of (18)F-FDG for average values in the whole tumor or average necrotic and viable tissues. The coregistered PET/MR images were in excellent agreement with histology, both visually and quantitatively, and allowed for validation of the last-time-point measurements. Strong correlations were found for the necrotic (r = 0.88) and viable fractions (r = 0.87) between histology and clustering. The GMM provided probabilities for each compartment with uncertainties expressed as a mixture of tissues in which the resolution of scans was inadequate to accurately separate tissues. The ANCOVA suggested that both ADC and (18)F-FDG in the whole tumor (P = 0.0009, P = 0.02) as well as necrotic (P = 0.008, P = 0.02) and viable (P = 0.003, P = 0.01) tissues were a positive, linear function of total tumor volume. ADC proved to be a positive predictor of (18)F-FDG in the whole tumor (P = 0.001) and necrotic (P = 0.02) and viable (P = 0.0001) tissues. The complementary information of (18)F-FDG and ADC longitudinal measurements in xenograft tumors allows for segmentation into distinct tissues when using the novel GMM pipeline. Leveraging the power of multiparametric PET/MRI in this manner has the potential to take the assessment of disease outcome beyond RECIST and could provide an important impact to the field of precision medicine.


PMID: 26659350

DOI: 10.2967/jnumed.115.163972

Other references

Marquet, R.L.; Bartelds, A.I.M.; Kerkhof, A.J.F.M.; Schellevis, Fçois.G.; van der Zee, J., 2005: The epidemiology of suicide and attempted suicide in Dutch General Practice 1983-2003. Many patients attempting or committing suicide consult their general practitioner (GP) in the preceding period, indicating that GPs might play an important role in prevention. The aim of the present study was to analyse the epidemiology of suicida...

Guerrero, R.; Menezes, J.; Reilly, D.A.; Garner, W.L., 2000: Wound care with Acticoat in patients with non-burn skin loss. Journal of Investigative Medicine 48(1): 59A, January

van der Burgt, E.P.M.; Sturkenboom, M.G.G.; Bolhuis, M.S.; Akkerman, O.W.; Kosterink, J.G.W.; de Lange, W.C.M.; Cobelens, F.G.J.; van der Werf, T.S.; Alffenaar, J-Willem.C., 2016: End TB with precision treatment!. European Respiratory Journal 47(2): 680-682

Ma, X.; Lv, P.; Ye, S.; Zhang, Y.; Li, S.; Kan, C.; Fan, L.; Liu, R.; Luo, D.; Wang, A.; Yang, W.; Yang, S.; Bai, X.; Lu, Y.; Ma, D.; Xi, L.; Wang, S., 2013: DT390-triTMTP1, a novel fusion protein of diphtheria toxin with tandem repeat TMTP1 peptide, preferentially targets metastatic tumors. Peptide-based therapies have emerged as one of the most promising therapeutics strategy in cancer-targeted therapy. Using our laboratory newly identified peptide TMTP1 and diphtheria toxin, we developed a new fusion protein that showed remarkable...

Domanin, A.A.; Shabanov, A.M., 1987: Ultrastructural analysis of villous tumors of the large intestine (with the use of a computer). As a result of an analysis of the literature and the authors' electron microscopic data on 23 cases of rectal villous tumors, a standardized complex of ultrastructural features and their variants were determined. The said characteristics were...

Ivanov, I.; Masalski, N.; Draganov, M.; Dikova, T.; Naĭdenova, N., 1977: Epizootiology of foot rot in sheep. Investigations were carried out on the outbreak and spread of foot rot in sheep as well as on the ways of its restriction and eradication. It was found that the disease had been introduced with the import of breeding animals, its further spread be...

Macdonald, G.; Sheldon, B., 1997: Community care services for the mentally ill: consumers' views. In this study a broadly representative sample of clients in the City of Westminster, receiving Care in the Community for reasons of mental ill-health, were interviewed regarding their experiences of, and levels of satisfaction with, services provi...

Kumar, A.; Siddiqi, M.Imran., 2010: Receptor based 3D-QSAR to identify putative binders of Mycobacterium tuberculosis Enoyl acyl carrier protein reductase. In the current study, the applicability and scope of 3D-QSAR models (CoMFA and CoMSIA) to complement virtual screening using 3D pharmacophore and molecular docking is examined and applied to identify potential hits against Mycobacterium tuberculos...

Anonymous, 1985: Classic articles in colonic and rectal surgery. Roscoe Reid Graham 1890-1948. The operative repair of massive rectal prolapse. Diseases of the Colon and Rectum 28(5): 374-379

Rios, P.; Li, X.; Köhn, M., 2013: Molecular mechanisms of the PRL phosphatases. The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver...