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A multimodal assessment of balance in elderly and young adults

, : A multimodal assessment of balance in elderly and young adults. Oncotarget 7(12): 13297-13306

Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechanical variables including: skeletal muscle-specific troponin T (sTnT), maximal strength measures derived from isometric grip and leg extension tasks, and postural sway captured from a force platform during a quiet stance task. These measures were performed in eight young and eleven elderly adults, along with estimates of fall risk derived from the Tinetti Balance Assessment. We observed age-related effects in all measurements, including a trend toward increased sTnT levels, increased postural sway, reduced upper and lower extremity strength, and reduced balance scores. We observed a negative correlation between balance scores and sTnT levels, suggesting its use as a biomarker for fall risk. We observed a significant positive correlation between balance scores and strength measures, adding support to the notion that muscle strength plays a significant role in postural control. We observed a significant negative correlation between balance scores and postural sway, suggesting that fall risk is associated with more loosely controlled center of mass regulation.


PMID: 26934319

DOI: 10.18632/oncotarget.7758

Other references

Westphalen, A.A.; Russell, A.M.; Buser, M.; Berthod, C.Rey.; Hutter, P.; Plasilova, M.; Mueller, H.; Heinimann, K., 2005: Evidence for genetic anticipation in hereditary non-polyposis colorectal cancer. Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited, colorectal cancer (CRC) predisposition syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, predominantly MLH1 and MSH2. Thus far, only...

Ueda, F.; Mimura, K.; Tasuchiya, S.I.hi; Kimura, K., 1993: Role of gap junctions in gastric mucosal protection. Japanese Journal of Pharmacology 61(SUPPL 1): 107P

Kirwan, J.F.; Subak-Sharpe, I.; Teimory, M., 1997: Bilateral acute angle closure glaucoma after administration of paroxetine. British Journal of Ophthalmology 81(3): 252-252

Willoughby, D.A.; Cecena Wood, G.; Oshima, R.G., 1996: Biological activities of an Alu element in transgenic mice, transfected mammalian cells, and at yeast telomeres. Molecular Biology of the Cell 7(SUPPL ): 631A

C.A.Eaves, F.R.Forsyth, J.S.Leefe, C.L.Lockhart, 1964: Effect of varying concentrations of oxygen with and without co2 on senescent changes in stored mcintosh apples grown under two levels of nitrogen fertilization. McIntosh apples from trees having a high and low content of N as determined by leaf analysis were stored in modified atmospheres of zero, 5, or 7% CO2 in a range of O2 levels from 2.5 to 20%. Fruit from the low N trees was highly susceptible to co...

Jocev, S.; Panowa, E.; Genev, G., 1967: On serum alkaline phosphatase in viral hepatitis and other liver diseases. Folia Medica 9(6): 349-356

Farhoudi, M.; Kermani, S.; Sadeghi-Bazargani, H., 2010: Relatively higher norms of blood flow velocity of major intracranial arteries in North-West Iran. Transcranial Doppler (TCD) is a noninvasive, less expensive and harmless hemodynamic study of main intracranial arteries. The aim of this study was to assess normal population values of cerebral blood flow velocity and its variation over age and g...

Nevajda, B.; Havelka-Mestrović, A.; Bilić, M.; Nevajda, A.Podvez.; Romić, D.; Vuletić, V.; Cukljek, S.; Sicaja, M.; Bocina, Z., 2013: Prevalence of the metabolic syndrome in the old institutionalized people in Zagreb, Croatia. Metabolic syndrome (MeS) is defined by a cluster of abnormalities comprising obesity, hypertension, carbohydrate intolerance and dyslipidemia. MeS increases the risk of developing various diseases, including coronary heart disease, stroke, periphe...

Curtis, P., 2005: Federal Trade Commission regulations and the food industry. The mission and activities of the Federal Trade Commission in relation to the protection of consumers against fraud and malpractice on the part of food industry players are discussed. The different departments which are under this commission are o...

Twardon, J., 1988: Effects of suckling and absence of suckling on uterine involution and fertility in cows. 140 randomly selected multi- and primiparous cows suckled their calves for 10 days, while in a control group, 130 calves were segregated from their dams immediatley after birth and bucket-fed 4 times a day with milk from their respective mothers....