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A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo

, : A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo. Drug Design, Development and Therapy 10: 1947-1959

Sepsis remains a leading cause of death worldwide. Despite years of extensive research, effective drugs to treat sepsis in the clinic are lacking. In this study, we found a novel imidazopyridine derivative, X22, which has powerful anti-inflammatory activity. X22 dose-dependently inhibited lipopolysaccharide (LPS)-induced proinflammatory cytokine production in mouse primary peritoneal macrophages and RAW 264.7 macrophages. X22 also downregulated the LPS-induced proinflammatory gene expression in vitro. In vivo, X22 exhibited a significant protection against LPS-induced death. Pretreatment or treatment with X22 attenuated the sepsis-induced lung and liver injury by inhibiting the inflammatory response. In addition, X22 showed protection against LPS-induced acute lung injury. We additionally found that pretreatment with X22 reduced the inflammatory pain in the acetic acid and formalin models and reduced the dimethylbenzene-induced ear swelling and acetic acid-increased vascular permeability. Together, these data confirmed that X22 has multiple anti-inflammatory effects and may be a potential therapeutic option in the treatment of inflammatory diseases.


PMID: 27390516

DOI: 10.2147/DDDT.S101449

Other references

Moskal, V., 1983: Phenotype correlations of reproduction traits in sows of the elite herd. Scientia agriculturae Bohemoslovaca5(4): 273-282

Ziemski, J.M.; Lopaciuk, S.; Rudowski, W., 1971: 2 cases of surgical treatment of splenic rupture in patients with hemophilia type A. Acta Haematologica Polonica 2(1): 87-90

Kuntoro, R.E.L.porte; Mazumdar, S., 1994: Approaches to quality control with an application to a new cancer registry in a developing country. Quality control should be maintained in all disease registries by appropriate statistical procedures to assure complete, accurate, reliable, and timely morbidity and mortality data. Shewhart control charts are recommended for evaluating item compl...

Fairall, L.; Finch, J.T.; Hui, C.F.; Cantor, C.R.; Butler, P.J., 1986: Studies of tobacco mosaic virus reassembly with an RNA tail blocked by a hybridised and cross-linked probe. Segments of cloned cDNA to tobacco mosaic virus RNA, 150--300-bases long, have been hybridised and cross-linked to the RNA, which has then been used for reassembly experiments. This enables the elongation reaction, which does not encapsidate the d...

Levy J.C., 1988: Psychogenesis and entropy. Revue de Bio-Mathematique (102): 5-25

Wang, X.; Huang, Y.; Wu, S.; Duan, N.; Xu, B.; Wang, Z., 2016: Simultaneous detection of Staphylococcus aureus and Salmonella typhimurium using multicolor time-resolved fluorescence nanoparticles as labels. NlmCategory="UNASSIGNED">Foodborne illnesses caused by Staphylococcus aureus and Salmonella typhimurium are common public health issues worldwide, affecting both developing and developed countries. In this study, aptamers labeled with...

Haider, R.; Islam, A.; Kabir, I.; Habte, D., 1996: Early complementary feeding is associated with low nutritional status of young infants recovering from diarrhoea. Young infants admitted to hospital for diarrhoea were studied to identify and understand the reasons for early complementary feeding and to examine its effect on nutritional status. Of 132 infants, 71 per cent were being breastfed, 24 per cent had...

Trieu, C.Vu., 2012: Leaving Vietnam. Texas Dental Journal 129(2): 166-167

Pratt, W.B.; Holloway, J.M., 2001: Incidence of hip fracture in Alaska Inuit people: 1979-89 and 1996-99. Review of records of the Alaska Native Medical Center in Anchorage, Alaska show that the incidence of hip fracture in Inuit women over 64 years of age was higher than the incidence in white US women in 1979-89 and had increased farther by 1996-99....

Wiater, J.Michael.; Fabing, M.H., 2009: Shoulder arthroplasty: prosthetic options and indications. Glenohumeral arthropathy and failed shoulder arthroplasty can lead to debilitating pain, reduced motion and strength, and limited function. Primary osteoarthritis, posttraumatic osteoarthritis, rheumatoid arthritis, cuff tear arthropathy, and oste...