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A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis

, : A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis. Atherosclerosis 239(2): 459-464

Atherosclerosis disease is a leading cause for mortality and morbidity. The narrowing/rupture of a vulnerable atherosclerotic plaque is accountable for acute cardiovascular events. However, despite of an intensive research, a reliable clinical method which may disclose a vulnerable patient is still unavailable. We tested the association of ADAM17 (A Disintegrin and Metallo Protease Domain 17) circulating substrates (sICAM-1, sVCAM-1, sIL6R and sTNFR1) with a second major cardiovascular events [MACEs] (cardiovascular death, peripheral artery surgeries, non-fatal myocardial infarction and non-fatal stroke) in 298 patients belonging to the Vascular Diabetes (AVD) study. To evaluate ADAM17 activity we create ADAM17 score through a RECPAM model. Finally we tested the discrimination ability and the reclassification of clinical models. At follow-up (mean 47 months, range 1-118 months), 55 MACEs occurred (14 nonfatal MI, 14 nonfatal strokes, 17 peripheral artery procedures and 10 cardiovascular deaths) (incidence = 7.8% person-years). An increased risk for incident events was observed among the high ADAM17 score individuals both in univariable (HR 19.20, 95% CI 15.82-63.36, p < 0.001) and multivariable analysis (HR 3.42, 95% CI 1.55-7.54, p < 0.001). Finally we found that ADAM17 score significantly increases the prediction accuracy of the Framingham Recurring-Coronary-Heart-Disease-Score, with a significant improvement in discrimination (integrated discrimination improvement = 9%, p = 0.012) and correctly reclassifying 10% of events and 41% of non-events resulting in a cNRI = 0.51 (p = 0.005). We demonstrated a positive role of ADAM17 activity to predicting CV events. We think that an approach that targets strategies beyond classic cardiovascular risk factors control is necessary in individuals with an established vascular atherosclerosis.


PMID: 25687272

DOI: 10.1016/j.atherosclerosis.2015.01.029

Other references

Kong Tan Boon, 1995: Engineering geology of the Ipoh-Gopeng segment of the North-South Highway. Warta Geologi = Newsletter of the Geological Society of Malaysia: , Pages 194. 1995.

D.Toledo, Piza S., 1960: A new mantid of Argentina. A new genus BRACHYPTEROMANTIS, and a new sp. BRACHYPTEROMANTIS bonariensis, found in Argentina, are described.

Bauxgart, Y.; Otto, A.; Schaefer, A.; Usbeck, E.; Cott, C.; Schott, A.; Tornack, M.; Wenzel, A.; Mossie, A.; Birkenmeier, G., 2005: Characterization of novel monoclonal antibodies for prostate-specific antigen (PSA) with potency to recognize PSA bound to alpha2-macroglobulin. Background: Different molecular forms of prostate-specific antigen (PSA) have been used to differentiate between benign prostatic hyperplasia and prostate cancer. Detecting PSA bound to endogenous inhibitors such as alpha1-antichymotrypsin (ACT) a...

Hu, B-Huang.; Su, J.; Messersmith, P.B., 2009: Hydrogels cross-linked by native chemical ligation. We describe the use of native chemical ligation (NCL) reaction to covalently cross-link soluble polymers into hydrogels. Macromonomers consisting of a four-armed poly(ethylene glycol) (PEG) core end-functionalized with either thioester or N-termin...

Strauss, R.; Wise, L., 1978: New concepts in the prevention, causes and treatment of postvagotomy diarrhea. Current Surgery 35(2): 77-84

Balogu D.O.; Lusk J.W.; Tomlinson J.E., 1989: Evaluation of brown midrib bmr 12 sorghum silage or corn silage as the sole forage for lactating dairy cows. Journal of Dairy Science 72(8): 2218

Scheufler, C.; Sebald, W.; Hülsmeyer, M., 1999: Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. Homodimeric bone morphogenetic protein-2 (BMP-2) is a member of the transforming growth factor beta (TGF-beta) superfamily that induces bone formation and regeneration, and determines important steps during early stages of embryonic development in...

Gill, B.J., 1993: The lizards of the Pitcairn Island Group, South Pacific. New material from Henderson and Ducie Islands, and a review of other available records, shows that six species of lizards (three geckos and three skinks) have been recorded from the Pitcairn Group. All are widespread in the South Pacific. Lepidoda...

Kurita A.; Takase B.; Horiuchi K.; Maruyama T.; Sugahara H.; Kondo S.; Nishioka T.; Mizuno K.; Isojima K.; Nakamura H., 1988: Painless myocardial ischemia in elderly patients with coronary heart disease compared with middle aged patients and its relation to treadmill testing and coronary hemodynamics. Journal of the American College of Cardiology 11(2 SUPPL A): 50A

Ak, K.; Isbir, S.; Bozkurt, Süheyla.; Civelek, A.; Arsan, S., 2010: Eosinophilic periarteritis of the left internal thoracic artery graft. Anadolu Kardiyoloji Dergisi 9(5): 425-426