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A simple and sensitive label-free fluorescence sensing of heparin based on Cdte quantum dots


, : A simple and sensitive label-free fluorescence sensing of heparin based on Cdte quantum dots. Luminescence 31(4): 958-964

A rapid, simple and sensitive label-free fluorescence method was developed for the determination of trace amounts of an important drug, heparin. This new method was based on water-soluble glutathione-capped CdTe quantum dots (CdTe QDs) as the luminescent probe. CdTe QDs were prepared according to the published protocol and the sizes of these nanoparticles were verified through transmission electron microscopy (TEM), X-ray diffraction (XRD) and dynamic light scattering (DLS) with an average particle size of about 7 nm. The fluorescence intensity of glutathione-capped CdTe QDs increased with increasing heparin concentration. These changes were followed as the analytical signal. Effective variables such as pH, QD concentration and incubation time were optimized. At the optimum conditions, with this optical method, heparin could be measured within the range 10.0-200.0 ng mL(-1) with a low limit of detection, 2.0 ng mL(-1) . The constructed fluorescence sensor was also applied successfully for the determination of heparin in human serum. Copyright © 2015 John Wiley & Sons, Ltd.

US$19.90

PMID: 26542329

DOI: 10.1002/bio.3058


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Castello, R., 2002: General H1-H2 blockade for anesthetic induction. Der Anaesthesist 51(5): 420-421

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Ravetch, J.V., 2002: A full complement of receptors in immune complex diseases. Journal of Clinical Investigation 110(12): 1759-1761

Kolev V.M., 1988: Changes in the metabolism of some photoassimilates following osmotic shock effect of applying agents enhancing drought resistance. The effect of some agents enhancing drought resistance on the content of the main photoassimilates (sugars and starch), the 14C inclusion in them and the changes in the protein composition of leaf parenchyma was studied in beans following an osmot...

Stokke K.T., 1971: Evidence for a new cholesterol esterase in human liver. Scandinavian Journal of Clinical & Laboratory Investigation Supplement 27(118): 50

Aliev, M.A.; Ismagilov, R.Z.; Kalyshev, R.S., 1998: The using of water-soluble form of vitamin E for protection of NHB-donors renal transplants. Nephrology Dialysis Transplantation 13(6): A281, June

Garcia Ruiz, A.; Cabezas Redondo, L., 1995: Study of the differences between industrially- and farmhouse-produced Manchego cheese within the Denomination of Origin quality control system. Nine samples of industrially-manufactured (IM) and 5 of farmhouse-manufactured (FM) Manchego cheese all complied with the physicochemical standards for Denomination of Origin although the IM samples had slightly higher mean pH, DM, ash and NaCl an...

McBlain, B.A.; Schmitthenner, A.F., 1991: Evaluations of recurrent selection for Phytophthora tolerance in soybean. The history of soyabean and rot caused by P. megasperma f.sp. glycinea in Ohio, genetic control, whole plant resistance, tolerance, race specificity of tolerance, Phytophthora genetics and stability, tolerance tests, tolerance in cv. Ripley and re...

Shteynberg D.S.; Sobolev I.D., 1969: Igneous activity of the Urals. Pages 39-42 1969