geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

APOE gene polymorphism and risk of coronary stenosis in Pakistani population


, : APOE gene polymorphism and risk of coronary stenosis in Pakistani population. Biomed Research International 2015: 587465-587465

Genetic variation in lipid regulatory genes, particularly APOE, significantly influences the risk of coronary artery disease (CAD). This study aimed to assess the association between APOE polymorphism and angiographically assessed coronary stenosis in Pakistani population. A total of 695 subjects (22.3% female, mean age = 54 ± 11 years) presenting with chest pain were enrolled after obtaining written informed consent. CAD stenosis/extent was assessed by angiography. Patients were classified as having severe stenosis (≥ 70%), moderate stenosis (30-69%), and mild stenosis (<30%). CAD patients with ≥ 70% stenosis (n = 491) were further categorized based on possessing one, two, or three vessel diseases to assess the disease extent. Genomic DNA from leukocytes was isolated with DNA purification kit (Qiagen) and APOE polymorphisms (E2/E3/E4) were determined using TaqMan assays. Six hundred and seventy-two of 695 subjects were successfully genotyped. The frequency of APOE∗4 carriers (3/4 and 4/4 genotypes) was significantly higher in severe stenosis group (≥ 70%) as compared to mild group (<30%) (22.8% versus 13.01%; P = 0.01). In multiple regression, the odds ratio for APOE∗4 carriers to develop ≥ 70% stenosis was 2.16 (95% CI: 1.29-3.79; P < 0.005). In conclusion, the presence of APOE∗4 allele is a significant risk factor to develop severe coronary stenosis (>70%) among Pakistanis.

US$19.90

PMID: 25883965

DOI: 10.1155/2015/587465


Other references

Scott, G.; Goode, K., 1995: Reporting the outcome of ethics review. Bulletin of Medical Ethics No. 110: 16-18

Adams, W.W.I.i; Demmig Adams, B., 1995: Xanthophyll cycle and temporal flexibility in regulation of thermal energy dissipation Seconds to seasons. Plant Physiology (Rockville) 108(2 SUPPL ): 37

Mongia, A.; Vecker, R.; George, M.; Pandey, A.; Tawadrous, H.; Schoeneman, M.; Muneyyirci-Delale, O.; Nacharaju, V.; Ten, S.; Bhangoo, A., 2012: Role of 11βHSD type 2 enzyme activity in essential hypertension and children with chronic kidney disease (CKD). The mineralocorticoid receptor is protected from excess of glucocorticoids by conversion of active cortisol to inactive cortisone by enzyme 11β-hydroxysteroid dehydrogenase type 2 present in the kidney. The metabolites of cortisol and cortisone a...

Guntheroth, W., 2012: Ventricular noncompaction. American Journal of Cardiology 108(12): 1842-1842

Thompson, P.M.; Sultana, P., 1996: Operation and maintenance performance and conflicts in flood-control projects in Bangladesh. Many embankments failed in severe floods in Bangladesh in 1987 and 1988, and concern grew over ways to improve flood-control projects. Embankments failed where they were eroded or were deliberately cut. They were cut by people living outside who b...

Lipp, M.; Koch, E.; Brandner, G.; Bredt, W., 1979: Simulation and prevention of retrovirus--specific reactions by mycoplasmas. From human mycosis fungoides tumor-derived cell lines, Mycoplasma hyorhinis was isolated. This mycoplasma shared the following characteristics with retroviruses: uptake of 3H-uridine, but not of 3H-thymidine in cell culture; banding at 1.16 g/ml s...

Marten, K.D., 1978: Species selection for Solomon Island forestry. Lists are given of over 100 species tested in selection and line planting trials, segregated by potential products (furniture and construction, utility, pulpwood poles or uncertain, and conifers). The text of the report summarizes the growth chara...

Adachi, K.; Chow, D.C.; Rothman, S., 1962: Metabolism of glycogen in skin and the effect of radiation. Continuous biosynthesis of glycogen was demonstrated by perfusion of the skin of dogs with uniformly labeled C(14)-glucose. If the skin is irradiated in vivo with an erythemal dose of x-rays 24 hours prior to perfusion, the uptake of radioactive g...

Hattori, S.; Ohkubo, K.; Urano, Y.; Sunahara, H.; Nagano, T.; Wada, Y.; Tkachenko, N.V.; Lemmetyinen, H.; Fukuzumi, S., 2006: Charge separation in a nonfluorescent donor-acceptor dyad derived from boron dipyrromethene dye, leading to photocurrent generation. Boron dipyrromethene (BODIPY), which is commonly used as an energy absorbing and transferring antenna molecule, has been modified to contain an electron donor moiety, 8-(2,4,5-trimethoxyphenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s...

Engleman, E.A.; Wong, D.T., 1994: Profound increases in extracellular hypothalamic norepinephrine concentrations after systemic administration of amitriptyline. Society for Neuroscience Abstracts 20(1-2): 383