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Adalimumab versus infliximab in treating post-operative recurrence of Crohn's disease: a national cohort study


, : Adalimumab versus infliximab in treating post-operative recurrence of Crohn's disease: a national cohort study. Revista Espanola de Enfermedades Digestivas 108(10): 642-647

Perform a comparison between adalimumab (ADA) and infliximab (IFX) in treating post-operative recurrence of Crohn's disease (a comparative analysis of efficacy and safety). From the 267 patients treated with Adalimumab or Infliximab between January 2005 and June 2014 in Romania, 44 received anti- TNF (tumor necrosis factor) therapy for prevention of post-operative recurrence. A comparison between patients treated with IFX and ADA was made with the Chi- square and t- student test, with the aid of the statistical program Mini Tab 17. Twenty-one patients received IFX and 23 ADA. This included 49% males (22/44), with a mean age of 41 years, mean disease duration of 6 years, and 84.1% had previously received azathioprine. The IFX group is comparable with the ADA group regarding most of the parameters, except for therapy duration. Mean duration of therapy was 33 months. The rate of complete response was comparable between the two groups: 67% in the IFX group vs. 78.3% in the ADA group, the same as the rate of re-resection, 19.1% vs. 4.4% and the rate of endoscopic recurrence, 29 vs. 33% at 12 months. Risk factors for postoperative recurrence (POR) (male sex, younger age, ileocolonic location, stricturing or penetrating behaviour) were studied, only ileocolonic location was found to be associated with Crohn's disease recurrence in patients treated with ADA. Overall infliximab and aalimumab are equally efficient in patients with resected Crohn's disease (CD) with a complete response of 72.7%, a rate of re-resection of 11.4 % and a rate of endoscopic recurrence of 35%. Ileocolonic location might be a predictive factor for loss of response to adalimumab in resected Crohn's disease patients.

US$19.90

PMID: 27651132

DOI: 10.17235/reed.2016.4483/2016


Other references

Kawanishi, H.; Hamada, H.; Masuoka, N., 2005: Activation factors of antioxidant enzyme activity in a purple sweet potato and a pione - Application of a functional estimation method for foods. Purple sweet potato extract strongly activated gluthaione peroxidase but did not catalase activity. On the other hand, pione extract specifically activated catalase but did not glutathine peroxidase. Present investigation was planned to pursue act...

Kastl, S.; Schoenleben, F.; Papadopoulos, T.; Hohenberger, W.; Matzel, K.E., 2001: Large lymph node metastasis gives hint to a glicentin positive small endocrine rectal carcinoma. In a patient with a small endocrine carcinoma of the rectum, an unusually large lymph node metastasis was the only preoperative clinical finding. Low anterior rectal resection with total mesorectal excision and lymph node dissection was performed....

Rahim, F.; Ullah, K.; Ullah, H.; Wadood, A.; Taha, M.; U.R.hman, A.; uddin, I.; Ashraf, M.; Shaukat, A.; Rehman, W.; Hussain, S.; Khan, K.Mohammed., 2015: Triazinoindole analogs as potent inhibitors of α-glucosidase: synthesis, biological evaluation and molecular docking studies. A new series of triazinoindole analogs 1-11 were synthesized, characterized by EI-MS and (1)H NMR, evaluated for α-glucosidase inhibitory potential. All eleven (11) analogs showed different range of α-glucosidase inhibitory potential with IC50 v...

Smith, E.D.; Veolitze, M.; Merkatz, R., 1971: Social aspects of abortion counseling for patients undergoing elective abortion. Clinical Obstetrics and Gynecology 14(1): 204-214

Jones B.F.; Conko Kathryn M.; Flinn J.M.; Linkous D.H.; Lanzirotti A.; Frederickson C.J.; Bertsch P.M.; Friedlich A.; Bush A.L., 2003: Effects of enhanced zinc in drinking water on brain and memory. Open-File Report - U S

Tregunna, E.B.; Krotkov, G.; Nelson, C.D., 1964: Further evidence on the effects of light on respiration during photosynthesis. Chlorophyll-rich and chlorophyll-deficient leaves of soybean, peperomia, and corn were compared for the effects of previous illumination on the rate of carbon dioxide evolution in the subsequent dark period. An infrared carbon dioxide analyzer was...

Pattle, R.E., 1961: The retention of gases and particles in the human nose. The literature on the retention of gases and particles in the human nose is surveyed. An experimental study using clouds of methylene blue particles of uniform diameters down to 1[mu], polydisperse clouds with mass median diameters (MMD3) 0.4[mu]...

Vries, D.P. de; Smeets, L., 1978: Hybrid tea-roses under controlled light conditions. 2. Flowering of seedlings as dependent on the level of irradiance. Under the experimental conditions described in the preceding abstract, mortality increased with decreasing light intensities. The percentage of flowering seedlings increased and that of aborting ones decreased with irradiance. For the populations...

Pérez, A.; Sánchez, J.L.; Almodóvar, P.I., 2003: Kaposi's sarcoma is not a neoplasm let alone a sarcoma. International Journal of Dermatology 42(10): 844-845

Bn, V.; Sawant, A.; Shah, C.; Badgujar, L.; Dang, A., 2015: How Insurance Claim Data Can Help in Health Outcomes Research: an Indian Perspective. Value in Health 18(7): A730-A731