+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study

, : Amide proton transfer magnetic resonance imaging of Alzheimer's disease at 3.0 Tesla: a preliminary study. Chinese Medical Journal 128(5): 615-619

Amide proton transfer (APT) imaging has recently emerged as an important contrast mechanism for magnetic resonance imaging (MRI) in the field of molecular and cellular imaging. The aim of this study was to evaluate the feasibility of APT imaging to detect cerebral abnormality in patients with Alzheimer's disease (AD) at 3.0 Tesla. Twenty AD patients (9 men and 11 women; age range, 67-83 years) and 20 age-matched normal controls (11 men and 9 women; age range, 63-82 years) underwent APT and traditional MRI examination on a 3.0 Tesla MRI system. The magnetic resonance ratio asymmetry (MTR asym ) values at 3.5 ppm of bilateral hippocampi (Hc), temporal white matter regions, occipital white matter regions, and cerebral peduncles were measured on oblique axial APT images. MTR asym (3.5 ppm) values of the cerebral structures between AD patients and control subjects were compared with independent samples t-test. Controlling for age, partial correlation analysis was used to investigate the associations between mini-mental state examination (MMSE) and the various MRI measures among AD patients. Compared with normal controls, MTR asym (3.5 ppm) values of bilateral Hc were significantly increased in AD patients (right 1.24% ± 0.21% vs. 0.83% ± 0.19%, left 1.18% ± 0.18% vs. 0.80%± 0.17%, t = 3.039, 3.328, P = 0.004, 0.002, respectively). MTR asym (3.5 ppm) values of bilateral Hc were significantly negatively correlated with MMSE (right r = -0.559, P = 0.013; left r = -0.461, P = 0.047). Increased MTR asym (3.5 ppm) values of bilateral Hc in AD patients and its strong correlations with MMSE suggest that APT imaging could potentially provide imaging biomarkers for the noninvasive molecular diagnosis of AD.


PMID: 25698192

DOI: 10.4103/0366-6999.151658

Other references

Feilacher, J.; Buchmann, I., 2015: Ida Buchmann - "love brings..." in the Gugging Gallery. Neuropsychiatrie 28(4): 226-228

Rane, J.P.; Harbottle, D.; Pauchard, V.; Couzis, A.; Banerjee, S., 2012: Adsorption kinetics of asphaltenes at the oil-water interface and nanoaggregation in the bulk. Asphaltenes constitute high molecular weight constituents of crude oils that are insoluble in n-heptane and soluble in toluene. They contribute to the stabilization of the water-in-oil emulsions formed during crude oil recovery and hinder drop-dro...

Czarniecki Stanislaw, 1982: Jan Jaskiewicz and his role in the history of geological sciences in Poland. Przeglad Geologiczny: 0, Pages 513-519. 1982.

Stahl D.A.; Lane D.J.; Olsen G.J.; Heller D.J.; Schmidt T.M.; Pace N.R., 1987: Phylogenetic analysis of certain sulfide oxidizing and related morphologically conspicuous bacteria by 5s ribosomal rna sequences. Comparisons of 5S ribosomal ribonucleic acid (rRNA) nucleotide sequences were used for the phylogenetic characterization of a number of "morphologically conspicuous" sulfide-oxidizing eubacteria and certain of their non-sulfide oxidizing...

Sataloff, R.T., 1989: Surgery for the voice?. Clinical Otolaryngology and Allied Sciences 14(3): 185-188

Wallnöfer, H.; Gopold, B.; Schneider, J., 1987: Studies on the bioequivalence of canrenone using pharmacokinetic data and clinical effects. Canrenon, an active metabolite of spironolactone, and the combination of Canrenon with hydrochlorothiazide (HCT) were examined on patients with essential hypertension, cardial oedemas and oedemas of different origin, and than compared to a product...

Schwille F.; Ubell K., 1982: Flow phenomena in an interconnected joint model. Gas- und Wasserfach, Wasser, Abwasser 123(12): 585-593

Neovius, K.; Johansson, K.; Rössner, S.; Neovius, M., 2009: Disability pension, employment and obesity status: a systematic review. Disability pensions incur huge societal costs in many countries. In Sweden, the three greatest drivers of such productivity losses are musculo-skeletal, circulatory and psychiatric disorders, all closely associated with weight status. We identifie...

Rashid, G.H.; Schaefer, R., 1985: The seasonal pattern of carbon dioxide evolution from two temperate forest catena soils. In acid mull and anmoor catena soils the CO2 evolution rate was on average three times higher in the anmoor than in the mull, but the organic carbon mineralization rate was higher in the mull. Rate of mineralization was lowest in autumn in both so...

McManis, D.L.; Bell, D.R., 1968: Risk-taking by reward-seeking, punishment-avoiding, or mixed-orientation retardates. American Journal of Mental Deficiency 73(2): 267-272