+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants

, : Aneuploidy: a common and early evidence-based biomarker for carcinogens and reproductive toxicants. Environmental Health 15(1): 97-97

NlmCategory="UNASSIGNED">Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.


PMID: 27729050

DOI: 10.1186/s12940-016-0180-6

Other references

Wink, K.; Weisser, P., 1980: Long term comparison between atenolol and a depot form of propranolol hydrochloride on the heart rate and blood pressure at rest and during physical work in normal subjects. Atenolol 100 mg and propranolol retard 160 mg were compared by a cross-over trial in 20 male volunteers with respect to their long action on heart rate and blood pressure at rest as well as during ergometric load tests. Both beta-receptor blocking...

Riggs B.S.; Honigman B.; Kulig K.W.; Rumack B.H., 1987: Methanol poisoning a case of alleged product tampering. Veterinary & Human Toxicology 29(6): 464

Sawai, K., 1972: Epidemiological study of cardiovascular diseases--correlation between serum lipids and findings related to hypertension. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 9(2): 69-83

Shermatov M.S.; Pulatov K.P.; Umarova G.K.; Ubaydullayev Z.S., 1989: Genesis, distribution and composition of the subsiding and deformational properties of loess soil and their solutions in the works of G. A. Mavlyanov. Uzbekiston Geologiya Zhurnali = Uzbekskiy Geologicheskiy Zhurnal 1989(6): 3-7

Alexander, M.P.; Doijode, S.D., 1995: Electromagnetic field, a novel tool to increase germination and seedling vigour of conserved onion (Allium cepa L.) and rice (Oryza sativa L.) seeds with low viability. Onion seeds, conserved for 5 years, with a reduced viability of only 41%, were exposed to a static magnetic field created by two identical bar magnets connected in a parallel circuit. The magnets were placed one above the other with opposing polar...

Mann, G., 1977: Nutrition for athletes. The nutritional aspects of athletic prowess are illustrated as a team effort: the offensive line contains the building, regulating and maintaining nutrients; on the left are the electrolytes and on the right are calcium, protein and iron. In the b...

Judenko A.E. (Yudenko A.Ye), 2006: Impact of oil-polluted areas on watercourses in conditions of seasonal-varying factors--Otsenka vozdeystviya neftezagryaznennykh territoriy na vodotoki v usloviyakh deystviya sezonnykh faktorov. Pages 183-187 2006

Ausman J.I., 1984: Neuro psychological outcome. Smith, Rd. . Stroke And The Extracranial Vessels. Xiv 375p. Raven Press: New York, N.y., Usa. Illus. P285-294

Johansson, A.; Fareed, K.; Omar, R., 1991: Analysis of possible factors influencing the occurrence of occlusal tooth wear in a young Saudi population. The purpose of this study was to attempt to correlate possible etiologic factors with the occurrence of occlusal tooth wear in a young Saudi population. The material comprised 90 individuals with a mean age of 22 years within a range of 19-25 year...

Angoulvant, D.; Mohammedi, I.; Duperret, S.; Bouletreau, P., 1999: Septic shock caused by Mycobacterium tuberculosis in a non-HIV patient. Intensive Care Medicine 25(2): 238-238