geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Angiotensin II control of regional haemodynamics in rats with aortocaval fistula


, : Angiotensin II control of regional haemodynamics in rats with aortocaval fistula. Experimental Physiology (): -

NlmCategory="UNASSIGNED">Regional perfusion is reduced and the renin-angiotensin system is activated in rats with aortocaval fistula. The effects of captopril (angiotensin converting enzyme inhibitor), losartan (AT1 receptor antagonist), and PD 123319 (AT2 receptor antagonist) on regional blood flow and vascular conductance were assessed in rats with aortocaval fistula and sham-operated rats. Control of blood flow and vascular conductance by angiotensin II was evaluated by serial bolus injections of captopril, losartan, and PD 123319 in anaesthetized rats. In rats with fistula, PD 123319 significantly decreased, while captopril and losartan increased, mesenteric blood flow. The decrease in mesenteric blood flow by PD 123319 was significantly greater in rats with fistula compared to sham. Captopril and PD 123319 significantly decreased renal blood flow compared to losartan which increased it. In sham rats, captopril and losartan significantly increased, while PD 123319 decreased, mesenteric and renal conductance. In rats with fistula, captopril and losartan significantly increased, while PD 123319 decreased, mesenteric conductance. The significant increase produced by losartan on mesenteric conductance was greater in rats with fistula compared to sham. PD 123319 produced a significantly greater decrease in renal conductance of aortocaval fistula compared to sham rats. Captopril, losartan and PD 123319 did not significantly affect perfusion in hindquarter in rats with fistula or sham. The renin-angiotensin system is more active in the control of regional haemodynamics in rats with aortocaval fistula, and acts as mechanism of maintaining normal arterial blood pressure in these animals. In rats with fistula, AT1 receptors predominate in regulating regional haemodynamics. This article is protected by copyright. All rights reserved.

US$19.90

PMID: 27427425

DOI: 10.1113/EP085717


Other references

Favre, L.I.; Spertini, F.; Corthesy, B., 2003: Simplified procedure to recover recombinant antigenized secretory IgA to be used as a vaccine vector. Induced protection mechanisms at mucosal surfaces involve secretory IgA (SIgA), a complex structure made of polymeric-dimeric IgA (IgA(p/d)) antibody associated with secretory component (SC). SIgA can adhere to M cells of the intestinal and nasal...

Baglia, L.A.; Bowers, W.J.; Ruddell, A., 1997: The avian C/EBPc gene encodes a highly conserved leucine zipper transcription factor. Gene 2 1997): 7-302

Ray, H.N.; Hiregaudar, L.S., 1960: Some observations on the life-history of Eimeria labbeana Pinto, 1928, a ooccidium of domestic pigeons at Calcutta. Proceedings of the Indian Science Congress, 473: 433

Anonymous, 2012: Haptic shape guides visual search. Crossmodal research has shown that information from one sensory modality can influence perceptual and attentional processes in other modalities. Here, we demonstrate a novel crossmodal interaction between haptics and vision, in which haptic shape...

Anonymous, 1963: London's Health. British Medical Journal 2(5372): 1546-1547

North R.G., 1978: Lateral variations in mantle wave dispersion. Eos, Transactions, American Geophysical Union 59(12): 1141

Heatherington, Anne C., 2003: Clinical pharmacokinetic properties of rHuEPO A review. Molineux, Graham [Editor, Reprint Author], Foote, M A [Editor, Reprint Author], Elliott, S G [Editor, Reprint Author] Erythropoietins and erythropoiesis: Molecular, Cellular, Preclinical, and Clinical Biology : 87-112

Watanabe A.; Nohira K.; Kuroda M.; Yura S.; Shirato M.; Kanai N., 1991: Adenocarcinoma of sublingual salivary gland a case report. A 40-year-old woman complained of a painless mass in the left side of the floor of the mouth. A 2 .times. 2 cm round, smooth, nontender mass was palpable on the left side of the floor of the mouth; it was fixed to the symphysis of the mandible. No...

Raunio, V.; Taipale, A., 1961: The action of ethylene oxide on polio virus adsorbed on HeLa cells.Removal of gas after treatment of cell cultures with ethylene oxide. Annales Medicinae Experimentalis et Biologiae Fenniae 39: 352-355

Sealey, J.E.; Itskovitz-Eldor, J.; Rubattu, S.; James, G.D.; August, P.; Thaler, I.; Levron, J.; Laragh, J.H., 1994: Estradiol- and progesterone-related increases in the renin-aldosterone system: studies during ovarian stimulation and early pregnancy. To investigate the degree to which endogenous increases in estradiol (E2) and progesterone (P4) are associated with changes in the renin system, we studied eight patients undergoing ovarian stimulation for in vitro fertilization (FSH/human menopau...