+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Artificial Neural Network Methods Applied to Drug Discovery for Neglected Diseases

, : Artificial Neural Network Methods Applied to Drug Discovery for Neglected Diseases. Combinatorial Chemistry & High Throughput Screening 18(8): 819-829

Among the chemometric tools used in rational drug design, we find artificial neural network methods (ANNs), a statistical learning algorithm similar to the human brain, to be quite powerful. Some ANN applications use biological and molecular data of the training series that are inserted to ensure the machine learning, and to generate robust and predictive models. In drug discovery, researchers use this methodology, looking to find new chemotherapeutic agents for various diseases. The neglected diseases are a group of tropical parasitic diseases that primarily affect poor countries in Africa, Asia, and South America. Current drugs against these diseases cause side effects, are ineffective during the chronic stages of the disease, and are often not available to the needy population, have relative high toxicity, and face developing resistance. Faced with so many problems, new chemotherapeutic agents to treat these infections are much needed. The present review reports on neural network research, which studies new ligands against Chagas' disease, sleeping sickness, malaria, tuberculosis, and leishmaniasis; a few of the neglected diseases.


PMID: 26234510

Other references

Peresedov, V.V.; Kugoev, A.I.; Shirshov, A.V., 1996: Computed tomographic ventriculo-cisternography in assessing cerebrospinal fluid circulation in neurological diseases. Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko: 20-20

Nakamura, A.; Mori, D.; Tojo, K., 2012: Evaluation of the predicted time-concentration profile of serum tulobuterol in human after transdermal application. We proposed an in vitro/in vivo/in silico method for evaluating the clinical performance of matrix type transdermal therapeutic systems (TTSs). This method is based on the following four approaches: (1) drug release experiment, (2) in vitro penetr...

Horne, S.M.; Prüss, B.M., 2006: Global gene regulation in Yersinia enterocolitica: effect of FliA on the expression levels of flagellar and plasmid-encoded virulence genes. This study describes the involvement of the sigma factor of the flagellar system, FliA, in global gene regulation of Yersinia enterocolitica. In addition to exhibiting a positive effect upon the expression levels of eight class III flagellar opero...

Collins, M., 1999: Amino acid racemization, peering into the black box. Amino Acids (Vienna) 17(1): 64-65

Fiorina, P.; Ansari, M.Javeed.; Jurewicz, M.; Barry, M.; Ricchiuti, V.; Smith, R.Neal.; Shea, S.; Means, T.K.; Auchincloss, H.; Luster, A.D.; Sayegh, M.H.; Abdi, R., 2006: Role of CXC chemokine receptor 3 pathway in renal ischemic injury. Chemokines play a major role in the recruitment of leukocytes in inflammation and in the regulation of T helper 1 (Th1)/Th2 immune responses. These mechanisms have been recognized to be important in the pathogenesis of renal ischemia-reperfusion...

Kaufman, S., 1957: The enzymatic conversion of phenylalanine to tyrosine. The conversion of phenylalanine to tyrosine requires the presence of at least 2 enzyme fractions, each of which was purified about 20-fold. TPNH was demonstrated as the co-factor in Reaction 1-TPNH + H+ + O2 + phenylalanine[forward arrow]TPN++H2O...

Kara, S.; Tayman, Cüneyt.; Tonbul, A.; Andiran, N.; Tatli, M.; Türkay, S., 2013: Congenital hypothyroidism presenting with postpartum bradycardia. Congenital hypothyroidism is a clinical condition characterized by lack of thyroid hormone because of thyroid gland developmental and thyroid hormone biosynthesis disorders. The most common cause of permanent hypothyroidism is congenital factors....

Coppenolle, H. van; Neerinckx, E.; Knapen, J., 1992: Physical fitness as a driving force to enhance psychological well-being in depressed patients: research hypothesis. The study focuses on the formulation of a research hypothesis about using physical activity in the treatment of depressive disorders. It gives a brief review of the symptomatology and the cognitive-behavioural model of depression, on which the par...

Vlasov V.V.; Karpova G.G.; Knorre D.G.; Pichko N.P.; Pait A.S., 1984: Rapid complementarily addressed alkylation of polyadenylic acid sequences of messenger rna by derivatives of oligothymidylates in krebs ascites carcinoma cells. Doklady Biochemistry 274(1-6): 68-71

Sardaru, D.; Pendefunda, L., 2014: Neuro-proprioceptive facilitation in the re-education of functional problems in facial paralysis. A practical approach. Facial paralysis, in the form of Bell's syndrome, is an acute paralysis of idiopathic origin. Disability in patients with this medical condition is the result of impairment or loss of complex and multidimensional functions of the face like em...