geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Association between type 1, type 2 cytokines, diabetic autoantibodies and 25-hydroxyvitamin D in children with type 1 diabetes


, : Association between type 1, type 2 cytokines, diabetic autoantibodies and 25-hydroxyvitamin D in children with type 1 diabetes. Journal of Endocrinological Investigation 39(12): 1425-1434

Vitamin D may play a role in the pathogenesis of type 1 diabetes (T1D). The aim of the current study was to determine the possible association between 25-hydroxyvitamin D [25(OH)D] levels and circulating levels of type 1 and type 2 cytokines, as well as the pathophysiology of T1D in children. A total of 250 T1D patients and 250 sex- and age-matched T1D-free controls were screened for 25(OH)D, hemoglobin A1c (HbA1c), type 1 and type 2 cytokines, C-reactive protein (CRP) and bone mineral metabolism, as well as antibodies against insulin, glutamic acid decarboxylase (anti-GAD 65) and islet cells. Our data showed that the plasma level of 25(OH)D was significantly lower in T1D patients and that there was a significant negative correlation between 25(OH)D levels and HbA1c values. There was a significant association between deficient levels of 25(OH)D and higher levels of cytokines (IFN-γ, TNF-α, IL-6, IL-1β, IL-4 and IL-10) and CRP. Total blood hemoglobin, the hematocrit percentage, body mass index SDS values, phosphate and magnesium levels were significantly lower in T1D patients than in T1D-free subjects. The levels of parathyroid hormone and alkaline phosphatase were significantly higher in T1D patients. Higher levels of cytokines were significantly associated with deficient levels of 25(OH)D. Moreover, in T1D patients, higher levels of islet antibodies, anti-GAD antibodies and anti-insulin antibodies were significantly associated with deficient levels of 25(OH)D. In type 1 diabetic children, deficient levels of 25(OH)D are associated with high levels of HbA1c, circulatory cytokines and antibody markers.

US$19.90

PMID: 27541155

DOI: 10.1007/s40618-016-0514-9


Other references

Feng, X.; Zhu, T.; Li, C.; Lin, S.; Zhang, Q.; Zhang, H.; Zeng, Q.; Li, Z., 2005: Redefinition of the Upper Triassic Xiaochaka Group in the Shuanghu area, northern Tibet, China, and its geological implications. Dizhi Tongbao. Dec; 2412: 1135-1140 (Serial No 127

Abu Khabar, K.S.; Armstrong, J.A., 1993: Optimization of the sensitivity and stability of WEHI 164 clone 13 in the presence of actinomycin-D for tumor necrosis factor bioassay. Journal of Leukocyte Biology 0(SUPPL ): 53

Danziger, P.Day.; Silverwood, R.; Koupil, I., 2011: Fetal growth, early life circumstances, and risk of suicide in late adulthood. Recent studies in Sweden and Scotland have found early life conditions to be associated with increased risk of attempted and completed suicide in adolescence and young adulthood. It is not known, however, whether early life conditions affect suici...

Trivedi, J.; Sarnaik, D.A.; Agrawal, S., 2003: Varietal variations of qualitative characters in tomato (Lycopersicon esculentum Mill.) grown under Chhattisgarh Region. An experiment was conducted to assess the qualitative characters of 22 cultivars/hybrids (comprising 9 hybrids and 13 cultivars) of tomato grown in spring-summer season of 1995-96 in Chhattisgarh, Madhya Pradesh, India. Among the cultivars/hybrids...

Alberts, D.S., 2000: A unifying vision of cancer therapy for the 21st century. Journal of Clinical Oncology 17(11 Suppl): 13-21

Ulu, E.Meltem.Kayahan.; Töre, Hüseyin.Gürkan.; Bayrak, A.; Güngör, Dş.; Coşkun, M., 2009: MRI of central nervous system abnormalities in childhood leukemia. To document the imaging abnormalities seen in the central nervous system (CNS) in childhood leukemia or as complications of its treatment. Magnetic resonance imaging (MRI) of 15 children with neurologic complications of leukemia or its treatment w...

Wang, P.; Liu, Y.H.; Xu, Q.S.; Zheng, Z.S., 2017: Treatment of intractable aspiration after partial laryngectomy by cuffed tracheostomy tube with inner cannula. <b>目的:</b> 探讨难治性误咽、呛咳的有效处理方法。 <b>方法:</b> 2010年5月至2015年6月,安徽医科大学第一附属医院耳鼻咽喉头颈外科共收治难治性误咽、呛咳的喉癌、...

Brien, F., 1979: Tipping chutes for getting sheep away. Agnotes Melbourne Dept of Agriculture: 79 (390 79)

Anonymous, 2000: A "direct hit" against liver tumors. Health News 6(2): 7-7

D'agostino G.; Chiari M.C.; Grana E., 1988: Formation and release of tritiated acetylcholine in the rat urinary bladder strip. The relationship between different frequencies of loading stimulation and [3H]acetylcholine (ACh) formation and release from nerve terminals has been investigated in extratrigonal strips of the urinary bladder of the rat. An increase in frequency...