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Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a hospital-based study

, : Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a hospital-based study. Cardiovascular Diabetology 14(): 140-140

Whereas a few studies have reported associations of serum omentin levels with subclinical atherosclerosis in patients with diabetes, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications. The aim of this study was to investigate the relationships of serum omentin levels and vascular complications including cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). We recruited 97 patients who evaluated complications of diabetes. CAN was assessed by five standard cardiovascular reflex tests according to Ewing's protocol. Diabetic nephropathy (DN), retinopathy (DR), and peripheral neuropathy (DPN) were evaluated. Serum omentin levels were assessed by ELISA. Atherosclerotic burden was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI). The prevalence of CAN increased borderline significantly across the omentin tertiles (p = 0.05) and CAN point increased significantly and progressively across the omentin tertiles (p = 0.013). The prevalence of other microvascular complications (DPN, DN, and DR) did not differ among omentin tertiles. The mean levels of baPWV also increased significantly and progressively across the omentin tertiles (p = 0.002). Serum omentin levels were significantly positively correlated with CAN point (p = 0.004) and borderline significantly correlated with baPWV (p = 0.05) after multivariate adjustment. Regarding linear regression analysis for CAN point, univariate regression analysis demonstrated that CAN point associated with omentin, diastolic blood pressure (DBP) and hsCRP. Multiple regression analysis revealed that omentin levels, together DBP and baPWV correlated with CAN point. This present study suggests that serum omentin levels may be independently associate with CAN in patients with T2DM.


PMID: 26466574

DOI: 10.1186/s12933-015-0303-3

Other references

Cagin, N.; Freeman, E.; Somberg, J.C.; Bounous, H.; Mittag, T.; Diaz, R.; Levitt, B., 1973: The influence of propranolol on ouabain uptake by the guinea pig heart. European Journal of Pharmacology 24(2): 256-261

Bugai, B.; Mishkov, F.; Pakhomov, A.; Starodumov, A.; Telitsyn, G., 1974: An effective apparatus for extinguishing forest fires. Lesnoe khoziaistvo: 6 66-70

Gupta, V.; Patil, B., 1983: Prospects of kubabul breeding in India Leucaena leucocephala, forage source. Leucaena leucocephala in India: proceedings of National Seminar Urulikranchan June 26-27-1981 edited by RN Kaul MG Gogate and NK Mathur: 166

Chang, P.L.; Canfield, R.E.; Ditkoff, E.C.; O'Connor, J.F.; Sauer, M.V., 1998: Measuring human chorionic gonadotropin in the absence of implantation with use of highly sensitive urinary assays for intact beta-core and free beta epitopes. Objective: To determine if human chorionic gonadotropin (hCG) can be absorbed from the uterine cavity in the absence of an embryo. Design: Prospective study. Setting: University-based assisted reproduction program. Patient(s): Eight functionally a...

Lloyd, P.M.rcus; Prather, K.A., 1995: The use of aerosol time-of-flight spectrometry for the characterization of combustion particles. Abstracts of Papers American Chemical Society 209(1-2): ANYL 37

Silverman, D.N., 1995: Proton transfer in carbonic anhydrase measured by equilibrium isotope exchange. Methods in Enzymology 249: 479-503

Stajduhar, K.; Funk, L.; Jakobsson, E.; Ohlén, J., 2011: A critical analysis of health promotion and 'empowerment' in the context of palliative family care-giving. Traditionally viewed as in opposition to palliative care, newer ideas about 'health-promoting palliative care' increasingly infuse the practices and philosophies of healthcare professionals, often invoking ideals of empowerment and parti...

Yellore, V.S.; Thakur, N.B.; Desai, A.J., 1999: Enhancement of growth and poly 3-hydroxybutyrate production from Methylobacterium sp. ZP24 by formate and other organic acids. Production of the polymer, poly 3-hydroxybutyrate (PHB), by Methylobacterium sp. ZP24 increased when sucrose-containing medium was partially substituted with low concentrations of several organic acids. Low concentrations of formate could enhance...

Cabalceta, G.; Molina, E., 2006: Critical nutrient levels in soils of Costa Rica with Mehlich 3 soil extractant. The critical levels of Ca, Mg, K, P, S, Cu, Zn, and Mn were studied in Ultisols, Inceptisols, Vertisols, and Andisols, using the extracting solution Mehlich 3. In Ultisols critical levels of 4.0, 0.8 and 0.2 cmol(+) l-1 were found for Ca, Mg, and...

Hahn, D.W.; Allen, G.; McGuire, J.L.; Kanojia, R.M.; Ostrowski, G., 1975: 17alpha-Ethyl-20alpha-and -20beta-dihydroprogesterones and other 17alpha-ethyl-substituted pregnanes as potential contragestational agents. 17alpha-20alpha- and 20beta-dihydroprogesterones and other 17alpha-ethyl-substituted pregnanes as potential contragestational agents were investigated in the rat, and the syntheses of 17 alpha-ethyl-substituted analogs of the 2 epimeric 20-dihydro...