geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion


, : Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion. Embo Journal 35(3): 239-257

Astrocytes are housekeepers of the central nervous system (CNS) and are important for CNS development, homeostasis and defence. They communicate with neurones and other glial cells through the release of signalling molecules. Astrocytes secrete a wide array of classic neurotransmitters, neuromodulators and hormones, as well as metabolic, trophic and plastic factors, all of which contribute to the gliocrine system. The release of neuroactive substances from astrocytes occurs through several distinct pathways that include diffusion through plasmalemmal channels, translocation by multiple transporters and regulated exocytosis. As in other eukaryotic cells, exocytotic secretion from astrocytes involves divergent secretory organelles (synaptic-like microvesicles, dense-core vesicles, lysosomes, exosomes and ectosomes), which differ in size, origin, cargo, membrane composition, dynamics and functions. In this review, we summarize the features and functions of secretory organelles in astrocytes. We focus on the biogenesis and trafficking of secretory organelles and on the regulation of the exocytotic secretory system in the context of healthy and diseased astrocytes.

US$19.90

PMID: 26758544

DOI: 10.15252/embj.201592705


Other references

Kaufman, P.E.; Mann, R.S.; Butler, J.F., 2010: Evaluation of semiochemical toxicity to Aedes aegypti, Ae. albopictus and Anopheles quadrimaculatus (Diptera: Culicidae). Mosquitoes are the most important vectors of human pathogens. Wide-scale use of pesticides has led to the development of resistance to most common insecticide groups. The need to develop novel products that have a low impact on human health and th...

Johnson J.D.; Happy A.J.; Compton R.G., 1998: The dawn of a new stone age for Auckland. The importance of a quality aggregate supply cannot be understated. In order to facilitate the projected growth of the greater Auckland Urban Area, the current high demand for aggregate in the Auckland Area is expected to continue. The urbanisatio...

Fadda, F.; Sacceddu, P., 1972: Study of the specific activity of expired Co2 in albino rats after oral administration of D-galactose-C14 (U) and D-glucose-C14 (U). Archivio di Fisiologia 69(2): 199-204

Kristjansdottir, G., 1996: Prevalence of self-reported back pain in school children: A study of sociodemographic differences. The study considers the prevalence of back pain experienced in a nationwide random sample of 2173 Icelandic school children aged 11-12 and 15-16. The study found a 20.6% prevalence of "at least weekly" back pain. The prevalence of back p...

Pacher F., 1973: Deformability of Rock Masses; mechanism and character of deformations, effects of loading and time--Deformabilite des massifs rocheux; mecanisme et caractere des deformations, effets de la charge et du temps--Verformbarkeit von Felsmassen: Mechanismus und Charakter der Verformungen-und Zeiteinfluss. Pages 213-257 1973

Beare, J.M., 2011: Generalised skin sensitivity following local application of acriflavine; report of a case. Lancet 1(6448): 410-410

Draaijers, L.; van Schelven, I.H.; Hendrix, Y., 2017: Two pulmonary lesions on an X-ray of the chest. We present an X-ray of a 89-year-old man, showing two solitary pulmonary lesions. Although malignancy was suspected, these lesions appeared to be intrafissural pleural effusions, caused by congestive heart failure. One week after treatment with fu...

Richter, S.; Lockwood, B.; Lockwood, D.; Allanson, J., 1989: Abnormal chromosome complement resulting from a familial inversion of chromosome 2. It has been suggested that pericentric inversions of chromosome 2 increase the risk for spontaneous abortion but do not increase the risk for unbalanced recombinant offspring. We report our experience of a familial pericentric inversion of chromos...

Lin, Y.Hong.; Shah, S.; Salem, N., 2011: Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. To investigate the effect of docosahexaenoic acid (DHA) without other highly unsaturated fatty acids (HUFA) on n-3 and n-6 essential fatty acid (EFA) metabolism and fatty acid composition in mammals, a stable isotope tracer technique was used in a...

Fernandez Chapela, A.M., 1950: Anterior insertion of the diaphragm; diaphragmatic hernia. Archivos Uruguayos de Medicina, Cirugia Y Especialidades 37(2): 237-241