+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Autonomic dysreflexia: a possible trigger for the development of heterotopic ossifications after traumatic spinal cord injury? : A clinical longitudinal study

, : Autonomic dysreflexia: a possible trigger for the development of heterotopic ossifications after traumatic spinal cord injury? : A clinical longitudinal study. European Journal of Trauma and Emergency Surgery 40(6): 721-726

The aim of this study was to investigate the influence of the initial American Spinal Injury Association Impairment Scale (AIS) category and the conversion rate in acute traumatic tetraplegic patients on the development of heterotopic ossifications (HO). The second objective was to prove the hypothesis that tetraplegic patients with autonomic dysreflexia (AD) develop HO more often than patients without AD. A retrospective analysis from 2002 to 2009 of 330 patients with spinal cord injuries was performed and led to the inclusion of 77 traumatic tetraplegic patients. Clinical data was reviewed to determine the appearance of HO (n = 8) and its possible coincidence with AD during urodynamics. Spearman's correlation coefficient was calculated to test the relationship between HO and initial AIS category or the change in AIS category within 6 weeks. A matched pair (age, neurological level of injury) analysis of two samples (n = 8 with/without appearance of HO; total n = 16) was performed. The appearance of HO was significantly correlated with an initial AIS A compared to incomplete tetraplegia at baseline (p < 0.017). The conversion of AIS A into incomplete tetraplegia was highly correlated with the incidence of HO (p < 0.003). AD showed a positive correlation with HO (r = 0.97, p = 0.001). An initial AIS A that converts early into an incomplete tetraplegia constitutes a risk factor for the development of HO. Additionally, AD constitutes an important trigger in the development of HO in acute traumatic tetraplegic patients.


PMID: 26814788

DOI: 10.1007/s00068-013-0353-8

Other references

Eersels, J.L.H.; Klok, R.P.; Verbeek, J.; Jonker, A.; Herscheid, J.D.M., 2003: Synthesis and in-vivo evaluation of 123I-zimelidine, a potential SPECT-radioligand for the SERT. Journal of Labelled Compounds & Radiopharmaceuticals 46(Supplement 1): S143, August

Liu, L.; Yenari, M., A., 2007: Therapeutic hypothermia: neuroprotective mechanisms. Hypothermia has long been known to be a potent putative neuroprotectant. Experimental evidence and clinical experience show that hypothermia protects the brain from cerebral injury. Recent insights into the mechanisms of cerebral ischemia and rep...

Rice, C.W.; Todd, T.C.; Blair, J.M.; Seastedt, T.R.; Ramundo, R.A.; Wilson, G.W.T., 1998: Belowground biology and processes. Knapp, A K [Editor], Briggs, J M [Editor], Hartnett, D C [Editor], Collins, S L [Editor] Long-Term Ecological Research Network Series; Grassland dynamics: Long-term ecological research in tallgrass prairie 244-264

Dorda, J.; De-Ambrosio, L., 1997: The Collection of Ichthyology of the Spanish Museo Nacional de Ciencias Naturales (CSIC). The characteristics and peculiarities of the Collection of Ichthyology of the Spanish Museo Nacional de Ciencias Naturales is presented. The principal contributions which have reached the collection in nearly 200 years of history, as well as the m...

Salowe, S.P.; Zhang, L.; Zokian, H.J.; Gesell, J.J.; Zink, D.L.; Wiltsie, J.; Ai, X.; Kavana, M.; Pinto, S., 2016: In Vitro Assays for the Discovery of PCSK9 Autoprocessing Inhibitors. NlmCategory="UNASSIGNED">PCSK9 plays a significant role in regulating low-density lipoprotein (LDL) cholesterol levels and has become an important drug target for treating hypercholesterolemia. Although a member of the serine protease...

Baroni, Timothy J., 1999: Taxonomic and mycogeographic notes on some Malaysian fungi. IV. Notes on Clitopilus and Rhodocybe. Descriptions of three new taxa of Entolomataceae are presented, Clitopitus apalus var. macrosporus, C. orientalis and Rhodocybe perplexa. Several other species of Clitopilus are discussed and a key to taxa of Clitopilus found in or around Malaysia...

Hagiwara, K.; Ozasa, H.; Oka, J.; Ichikawa, T., 1992: Kidney injury induced by GSH depletion and vitamin E deficiency in rats and prevention by GSH ester administration. 4-week-old male Wistar rats were fed on a vitamin E (VE)-deficient diet for 8 weeks, followed by i.p. injection of DL-buthionine-[S, R]-sulfoximine (BSO), in inhibitor of gamma -glutamylcysteine synthetase, at 1 mmol/kg body weight. Rats in a glut...

Dieterich, J.M.; Hartke, B., 2014: A graph-based short-cut to low-energy structures. A new graph-based move class for global optimization of cluster structures is presented. Its performance and efficiency is analyzed for water clusters (H2O)n, n = 24, 61. This analysis indicates superior basin exploitation capabilities of the new...

Anonymous, 2012: New combinations and typifies in the genus Vernonanthura Vernonieae, Asteraceae. El g nero Vernonanthura H. Rob. (Vernonieae, Asteraceae) fue establecido para segregar las especies inicialmente incluidas en Vernonia Schreb. secci n Lepidaploa (Cass.) DC. subsecci n Paniculatae Benth. & Hook. Tal como se delimita actualmente, V...

Megyesi, J.; Andrade, L.; Vieira, J.; Safirstein, R.; Price, P.M., 2000: Uncoordinated cell cycle activity in p21 negative mice increases severity of ischemia-reperfusion acute renal failure. Journal of the American Society of Nephrology 11(Program and Abstract Issue): 461A, September