+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biological chemistry of hydrogen sulfide and persulfides

, : Biological chemistry of hydrogen sulfide and persulfides. Archives of Biochemistry and Biophysics (): -

NlmCategory="UNASSIGNED">Hydrogen sulfide (H2S) has been traditionally considered to be a toxic molecule for mammals. However, it can be formed endogenously and exert physiological effects with potential health benefits. H2S can partition two-fold in biological membranes and traverse them rapidly, diffusing between compartments. H2S reactivity has similarities to that of thiols, although it is less nucleophilic than thiols and it can form different products. H2S can react with oxidants derived from the partial reduction of oxygen, but direct scavenging is unlikely to explain H2S protective actions. Important effects are exerted on mitochondria including the stimulation or the inhibition of the electron transport chain. Possible mechanisms for unleashing biological consequences are the reactions with metal centers and with thiol oxidation products. The reactions of H2S with disulfides (RSSR) and sulfenic acids (RSOH) lead to the formation of persulfides (RSSH). Persulfides have enhanced nucleophilicity with respect to the corresponding thiol, consistent with the alpha effect. Besides, the inner and outer sulfurs can both act as electrophiles. In this review, we describe the reactions of H2S with oxidized thiol products and the properties of the persulfides formed in the context of the chemical biology of H2S.


PMID: 27697462

DOI: 10.1016/

Other references

Suhaila Mohamed; Mohamed Mustapha Noordin; Chin TeoKwok; Rais, R.; Yon TanThong, 2001: The efficacy of Centella asiatica (Pegaga) in alleviating cholesterol induced cardiovascular, hepatic and renal damages in rats. The efficacy of C. asiatica in alleviating cardiovascular, hepatic and renal damages in rats was studied. Twenty-four male Sprague-Dawley rats were fed for 8 weeks with 4 different diets: normal commercial rat pellets (N), 1% cholesterol diet (C),...

Hrncir, E., 2003: Conception of the field Occupational Diseases. The contribution presents the proposal of the conception of the field "Occupational Diseases" in the version, which was approved by the committee of the Society for Occupational Diseases of the Czech Medical Association of J. E. Purkyne...

Nussbaumer, A., 1961: Apropos of the surgical treatment of gastroduodenal ulcer. Study of 804 operated cases. Annales de Chirurgie 15: 1257-1263

Molloy, C.; Cagney, C.; O'Brien, S.; Iversen, C.; Fanning, Séamus.; Duffy, G., 2010: Surveillance and characterisation by pulsed-field gel electrophoresis of Cronobacter spp. in farming and domestic environments, food production animals and retail foods. Cronobacter spp. (formally Enterobacter sakazakii) has been linked to illness in infants from contaminated powdered infant formula, however, there is limited information on the environmental sources and potential transmission routes of this pathog...

Fal, W., 1979: Mastocytes, histamine and serotonin in the liver, spleen, kidneys and suprarenal glands, as well as plasmatic kinins, during experimental trichinelliasis in rats. Experiments on 110 rats showed that during infection with Trichinella spiralis (2000 larvae/rat) the increase in mast cell numbers was not the same in the various organs examined and was not always accompanied by an increase in the level of biolog...

Kelly, J., 1970: A cooperative program between hospital and industrial nurses. Occupational Health Nursing 18(9): 13-14

Borst, C.; Wieling, W., 1985: Getting up suddenly: physiological and clinical significance of acute cardiovascular consequences. Nederlands Tijdschrift Voor Geneeskunde 129(4): 156-160

Carmody, Kg, 1971: Quality control and the marketing of Australias butter and cheese. Australian journal of dairy technology 26 (3) 75-76

Sakalauskas K.; Suveizdis P., 1998: Tectonic zones of oil accumulation and perspectives of search for the oil fields. Pages 13-16 1998

Barton, K.E.; Boege, K., 2017: Future directions in the ontogeny of plant defence: understanding the evolutionary causes and consequences. Plant defence often varies by orders of magnitude as plants develop from the seedling to juvenile to mature and senescent stages. Ontogenetic trajectories can involve switches among defence traits, leading to complex shifting phenotypes across pla...