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Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi


, : Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi. Journal of Natural Products 79(6): 1658-1667

Incubation of salpichrolide A (1) with Rhizomucor miehei produced hydroxylation in rings B and C (C-7 and C-12) and led to C-5-C-6 epoxide opening, while incubation of salpichrolides C (2) and G (3) with R. miehei led to epoxide opening at the C-24-C-25 and C-5-C-6 positions, respectively. Biotransformation of salpichrolide A (1) with Cunninghamella elegans produced stereoselective hydroxylated, oxidized, and reduced derivatives in different positions of the A, B, and C rings and C-5-C-6 epoxide opening. In addition, selective epoxide opening at the C-5-C-6 or C-24-C-25 positions was obtained from the incubation of salpichrolide A (1) with Curvularia lunata.

US$19.90

PMID: 27285201

DOI: 10.1021/acs.jnatprod.6b00310


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