+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi

, : Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi. Journal of Natural Products 79(6): 1658-1667

Incubation of salpichrolide A (1) with Rhizomucor miehei produced hydroxylation in rings B and C (C-7 and C-12) and led to C-5-C-6 epoxide opening, while incubation of salpichrolides C (2) and G (3) with R. miehei led to epoxide opening at the C-24-C-25 and C-5-C-6 positions, respectively. Biotransformation of salpichrolide A (1) with Cunninghamella elegans produced stereoselective hydroxylated, oxidized, and reduced derivatives in different positions of the A, B, and C rings and C-5-C-6 epoxide opening. In addition, selective epoxide opening at the C-5-C-6 or C-24-C-25 positions was obtained from the incubation of salpichrolide A (1) with Curvularia lunata.


PMID: 27285201

DOI: 10.1021/acs.jnatprod.6b00310

Other references

Nguyen Quang Tan; Pham Thanh Binh, 1994: Harmony or conflict? Apis mellifera and Apis cerana in southern Vietnam. In a comparison of costs and income from beekeeping with A. cerana (C) and with A. mellifera (M), it is assumed that a household can manage, on average, 50 C colonies, whereas one beekeeper can manage 870 M combs (perhaps 90 or more colonies, depe...

Nawanil, C.; Vittayakorn, W.; Muanghua, R.; Niemcharoen, S.; Prachayawarakorn, J.; Vittayakorn, N., 2013: The effect of thai glutinous rice starch on the synthesis of lead zirconate (PbZrO3) nanofibers via the electrospinning method. This study synthesized blended lead zirconate (PbZrO3;PZ)/poly(ethylene oxide)(PEO)/Glutinous rice starch (GRS) nanofibers by the electrospinning method. A number of parameters such as the ratio between PEO and GRS and calcination temperature have...

Mizouchi T.; Taniguchi T.; Fujii Kadowaki J.; Yonemasu K.; Sasaki T.; Kobata A., 1982: Structures of the asparagine linked sugar chains of subcomponent c 1q of bovine complement c 1. Bovine C1q, a subcomponent of complement C1, contains 6 asparagine-linked sugar chains in 1 molecule. The sugar chains are exclusively distributed in the noncollagenous regions. The sugar chains were liberated as radioactive oligosaccharides from...

Lokich, J.J.; Moore, C., 1984: Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome. Annals of Internal Medicine 101(6): 798-799

Pena, S.Barbosa.; Diogo, M.José.D'Elboux., 2005: Factors favoring the participation of aged inpatients' caregivers in care. This study aimed to identify and analyze what factors favor the participation of aged inpatients' caregivers in care during the hospitalization period, according to relatives and nursing group members responsible for care delivery. Thirty age...

Williams, R.F.; Sims, T.L.; Tracey, L.; Myers, A.L.; Ng, C.Y.C.; Poppleton, H.; Nathwani, A.C.; Davidoff, A.M., 2010: Maturation of tumor vasculature by interferon-beta disrupts the vascular niche of glioma stem cells. The vascular niche necessary for cancer stem cell maintenance is a potential target for cancer therapy. Human glioma xenografts were treated with IFN-β delivered systemically via a liver-targeted, adeno-associated viral vector. The vascular niche...

Langley, J.; Crosado, B., 1984: Two safety aspects of public playground climbing equipment. The height of and surface under public playground climbing equipment in Dunedin were recorded. Twenty-eight percent of the equipment exceeded the maximum height specification of a British standard and the majority of equipment was mounted over non...

Mehrotra V., 1970: Studies on vesperugidendrium pandei new species a digenetic trematode from the intestine of bat. Research Bulletin Of The Panjab University Science2: 201-203

Casanovas, J.M.; Paez, X.; Artigas, F., 1998: Control of the activity of dorsal raphe serotonergic neurons by lateral hypothalamus Microdialysis evidence. Society for Neuroscience Abstracts 24(1-2): 1105

Wechsler, R.J.; Yellen Shaw, A.; Monroe, J.G., 1993: Mechanisms of neonatal B cell unresponsiveness to antigen. Journal of Cellular Biochemistry Supplement 0(17 PART B): 223