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Body composition and metabolic risk in small for gestational age children treated with growth hormone


, : Body composition and metabolic risk in small for gestational age children treated with growth hormone. Medicina Clinica 147(6): 231-237

Small for gestational age (SGA) children are at increased risk of metabolic syndrome. Our objective is to evaluate changes in body composition produced by growth hormone (GH) treatment. A group of 28 SGA children without catch-up growth and undergoing treatment with GH was selected for evaluation. Over the course of 3 years from the beginning of the treatment with GH, the children's body composition variables (bone mineral density [BMD], fat and lean body mass proportion) were evaluated annually with dual-energy X-ray absorptiometry. A study of correlation between metabolic and body composition variables was also made. Treatment with GH produces a reduction in fat mass proportion in relation to lean body mass, decreasing from 25.94±6.09 to 22.88±5.38% (P=.034). In the abdominal regions we observe an increase in lean mass, from 1,356,91±426,71 to 2,570,96±814,36g (P=.000) and a tendency for visceral fat deposits to decrease. BMD in lumbar vertebrae improved from -1.55±0.68 to -0.90±0.79Z (P=.019). Treatment with GH produces changes in body composition, improving BMD and increasing the proportion of lean body mass with a reduction in fat mass. If these changes persisted into adulthood, they may cause a reduction in the metabolic and cardiovascular risk in this group of patients.

US$19.90

PMID: 27423655

DOI: 10.1016/j.medcli.2016.06.002


Other references

Ducoff, H.S.; Jayaraman, S.; Blumenthal, L.K., 1984: Repair studies utilizing a fly-pupariation model of postmitotic cell response. Delay in pupariation of irradiated fly (and other insect) larvae results from a neuroendocrine disturbance and represents a dose-dependent response of differentiated postmitotic tissue. Many experimental manipulations (e.g. heating) may themselves...

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Koike T.; Takashima A.; Murata Y.; Chiba T., 1983: Effects of gluco corticoid or nerve growth factor on the major catecholamines in pc 12 pheo chromo cytoma cells a high performance liquid chromatography electrochemical detection study. Neuroscience Letters (SUPPL 13): S69

Lahiri, M.; Wolf, E., 2012: Spectral changes of stochastic beams scattered on a deterministic medium. It is well known that scattering of a polychromatic plane wave by a random medium, i.e., by a medium whose refractive index varies randomly with position, may produce frequency shifts of spectral lines. It has been a common perception that a rando...

Hardell, L.; Nasman, A.; Pahlson, A.; Hallquist, A.; Mild, K.H.nsson, 1999: Use of cellular telephones and the risk for brain tumours: A case-control study. The use of cellular telephones has increased dramatically during the 1990's in the world. In the 1980's the analogue NMT system was used whereas the digital GSM system was introduced in early 1990's and is now the preferred system....

Anonymous, 2005: Right potash levels are vital to achieve optimum breadmaking wheat results. Farmers Weekly 142(4

Mohan, J.C.; Tomar, D.; Shekhar, C.; Aggarwal, M., 2009: Prominent isovolumic relaxation velocities in mitral and tricuspid inflows in cardiac tamponade: normalisation after pericardiocentasis. Indian Heart Journal 59(4): 366-369

Grobin, A.Chistina.; Heenan, E.J.; Lieberman, J.A.; Morrow, A.Leslie., 2003: Perinatal neurosteroid levels influence GABAergic interneuron localization in adult rat prefrontal cortex. Neurosteroids are a class of steroids synthesized de novo in the brain, several of which are potent modulators of GABA(A) receptor function. In developing brain GABA(A) receptor, stimulation plays a trophic role. Cortical levels of the GABAergic n...

Adesodun J.K.; Davidson D.A.; Mbagwu J.S.C., 2008: Soil quality assessment of an oil-contaminated tropical Alfisol amended with organic wastes using image analysis of pore space. Petroleum products are the most common source of pollution in Nigeria. We studied changes of the pore space of a soil contaminated with petroleum products by image analysis; and also assessed the applicability of fractal scaling of the pore surfac...

Smith, L.; Norgate, S.H.; Cherrett, T.; Davies, N.; Winstanley, C.; Harding, M., 2015: Walking school buses as a form of active transportation for children-a review of the evidence. Walking school buses (WSBs) offer a potentially healthier way for children to get to school while reducing traffic congestion. A number of pressing societal challenges make it timely to evaluate evidence of their value. Studies that focused solely...