geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions


, : Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions. Nutrients 8(11): -

Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditions; normoxia, hypoxia and hypoxia + carbohydrate supplementation. Blood samples were collected at rest, at the end of exercise and after 60 min of recovery. To evaluate hypoxia + carbohydrate supplementation, volunteers received a solution of 6% carbohydrate (maltodextrin) or a placebo (strawberry-flavored Crystal Light®; Kraft Foods, Northfield, IL, USA) every 20 min during exercise and recovery. Statistical analyses comprised analysis of variance, with a one-way ANOVA followed by the Tukey post hoc test with a significance level of p < 0.05. Under normoxic and hypoxic conditions, there was a significant increase in the concentration of IL-6 after exercise and after recovery compared to at rest (p < 0.05), while in the hypoxia + carbohydrate group, there was a significant increase in the concentration of IL-6 and TNF-α after exercise compared to at rest (p < 0.05). Furthermore, under this condition, TNF-α, IL-2 and the balance of IL-2/IL-4 were increased after recovery compared to at rest (p < 0.05). We conclude that carbohydrate supplementation modified the IL-6 and TNF-α serum concentrations and shifted the IL-2/IL-4 balance towards Th1 in response without glycemic, glutaminemia and cell damage effects.

US$19.90

PMID: 27827949

DOI: 10.3390/nu8110706


Other references

Pinto, A.Filipa.; Ebrahimi, M.; Saleeb, M.; Forsberg, Åke.; Elofsson, M.; Schüler, H., 2016: Identification of Inhibitors of Pseudomonas aeruginosa Exotoxin-S ADP-Ribosyltransferase Activity. The gram-negative bacterium Pseudomonas aeruginosa is an opportunistic pathogen associated with drug resistance complications and, as such, an important object for drug discovery efforts. One attractive target for development of therapeutics is th...

Foy, J.M.; Furman, B.L., 1973: Effect of single dose administration of diuretics on the blood sugar of alloxan-diabetic mice or mice made hyperglycaemic by the acute administration of diazoxide. 1. Frusemide produced hyperglycaemia in mice when administered together with diazoxide. The interaction between the drugs in elevating the blood sugar was shown to be additive.2. The diuretic, natriuretic and kaliuretic effects of frusemide were v...

Inaba, A.; Yokota, T.; Shiojiri, T.; Yamada, M., 1997: Two siblings with nerve conduction abnormalities indicating an acquired type of demyelinating neuropathy. Muscle & Nerve 20(5): 608-610

Purvis, A.C., 1984: Importance of water loss in the chilling injury of grapefruit stored at low temperature. Differences in chilling injury susceptibility of fruits harvested from the exterior or interior of the canopy were used to investigate the hypothesis that water loss is related to chilling injury symptom development during low-temperature storage....

Lawrence, T., 1982: Registration of Clarke intermediate wheatgrass (Reg. No. 81). This 20-clone synthetic variety of Agropyron intermedium is drought tolerant, winter hardy and high yielding. Dry matter yield equalled that of Chief and was 7% higher than that of Greenleaf. Seed yield was 28% higher than that of Chief and 45% hi...

Huneycutt, H., 1989: Forage variety performance test 1987-88. Results are presented of trials of forage cultivars of Lolium multiflorum, Secale cereale, Triticale, Dactylis glomerata, L. perenne, Bromus inermis, Sorghum bicolor X S. sudanense, Pennisetum americanum, Trifolium pratense and T. repens at Fayett...

Vos, A.W.F.; Wisselink, W.; Marcus, J.T.; Manoliu, R.A.; Rauwerda, J.A., 2002: Aortic aneurysm pulsatile wall motion imaged by cine MRI: a tool to evaluate efficacy of endovascular aneurysm repair?. to evaluate cine MRI as a means of determining the two-dimensional pulsatile wall motion (2D-PWM) of abdominal aortic aneurysm (AAA). prospective study of 21 patients with AAA. 2D-PWM was defined as change in cross-sectional area. the median diast...

Zakladnoi, G.A., 2004: Disinfection of grain. Make your own choice. High rates of multiplication of stored products pests, e.g. rice weevil [Sitophilus oryzae] on rice, economic losses and deterioration of quality of grain are outlined. Advantages of using contact insecticides for control of stored grain compared...

Gottschlich, S.; Goeroegh, T.; Folz, B.J.; Lippert, B.M.; Werner, J.A., 1997: Optimized differential display and reamplification parameters for silver staining. Differential display (DD) is a powerful instrument to detect differences in gene expression of malignant and normal cells. An optimized silver staining protocol was used to compare mRNA expression of keratinocytes and squamous cell carcinoma cells...

Pattani, V.P.; Li, C.; Desai, T.A.; Vu, T.Q., 2008: Microcontact printing of quantum dot bioconjugate arrays for localized capture and detection of biomolecules. The nanometer size scale of quantum dots (QDs) along with their unique luminescent properties offers great potential as photostable, color-metrically addressable nanoparticle platforms for high-throughput detection and identification of proteins....